As one of the main areas of tropical storm action in the northwestern Pacific Ocean,South China experiences several typhoons each year,and coastal erosion is a problem,making the area a natural testing ground for stud...As one of the main areas of tropical storm action in the northwestern Pacific Ocean,South China experiences several typhoons each year,and coastal erosion is a problem,making the area a natural testing ground for studying the dynamic geomorphological processes and storm response of promontory-straight coasts.This study is based on three years of topographic data and remote sensing imagery of Gulei Beach and uses topographic profile morphology,single width erosion-accretion and mean change,combined with the Coastsat model to quantify the seasonal and interannual variability and storm response of the beach and to explain the evolution of shoreline change and beach dynamics geomorphology in the last decade.Gulei Beach has been in a state of overall erosion and local accretion for a long time,with relatively obvious cyclical changes;seasonal changes are also obvious,which are mainly characterized by summer accretion and winter erosion,with accretion at the top of the bay and accretion and erosion on the north and south sides of the bay corner,respectively;the seasonal erosion-accretion volume of the beach profile ranges from-80 m3/m to 95.52 m3/m,and the interannual erosion-accretion volume ranges from-69.09 m3/m to 87.31 m3/m.The response of beaches to typhoons with different paths varies greatly depending on the length,slope,orientation and scale of beach development.The large and gently developing Futou beach is less responsive to storms,while the less developed headlands in the southern Gulei Peninsula are more susceptible to disturbance by external factors and respond more strongly to typhoons.Storm distance is more influential than storm intensity.Under the influence of human activities,obvious erosion hotspots develop during normal weather,but storm processes produce redistribution of beach material patterns,and erosion hotspots disappear after storms.The results of this study enrich the theory of beach dynamics geomorphology and provide technical support for disaster prevention and mitigation,as well as ecological restoration of coastal zones.展开更多
In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture network.It has been proven to cause inaccurate pro...In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture network.It has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture communication.In addition,most of the existing models are solved analytically based on Laplace transform and numerical inversion.Hence,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix depletion.To simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the microfractures.Then,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by integration.Finally,a relationship between oil rate and production time in real-time space is obtained.The new model is verified against classical analytical models.When the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,respectively.Certainly,the new model also has an excellent agreement with the numerical model.The model is then applied to two actual tight oil wells completed in western Canada sedimentary basin.After identifying the flow regime,the solution suitably matches the field production data,and the model parameters are determined.Through these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.展开更多
To the editor:Mood disorders(MD)are serious mental illnesses that commonly affect adolescents,leading to a high incidence of suicidal behaviour.1 In China,the suicide attempt(SA)rate for adolescents with MD is 51.96%,...To the editor:Mood disorders(MD)are serious mental illnesses that commonly affect adolescents,leading to a high incidence of suicidal behaviour.1 In China,the suicide attempt(SA)rate for adolescents with MD is 51.96%,2 and over 500000 adolescent SA are reported annually in the USA due to depression.3 Risk factors for SA include gender,hormone levels,family conflict and,particularly,negative cognitive styles such as rumination.展开更多
Activation of cannabinoid receptor type 1 on presynaptic neurons is postulated to suppress neu- ~ ~ ~ 2+ ~ ~ 2+ rotransmlsslon by decreasing Ca reflux through high voltage-gated Ca channels. However, recent studies...Activation of cannabinoid receptor type 1 on presynaptic neurons is postulated to suppress neu- ~ ~ ~ 2+ ~ ~ 2+ rotransmlsslon by decreasing Ca reflux through high voltage-gated Ca channels. However, recent studies suggest that cannabinoids which activate cannabinoid receptor type 1 can increase neurotransmitter release by enhancing Ca2+ influx in vitro. The aim of the present study was to investigate the modulation of intracellular Ca2+ concentration by the cannabinoid receptor type 1 agonist anandamide, and its underlying mechanisms. Using whole cell voltage-damp and calcium imaging in cultured trigeminal ganglion neurons, we found that anandamide directly caused Ca2+ influx in a dose-dependent manner, which then triggered an increase of intracellular Ca2+ concentration. The cyclic adenosine and guanosine monophosphate-dependent protein kinase systems, but not the protein kinase C system, were involved in the increased intracellular Ca2+concentration by anandamide. This result showed that anandamide increased intracellu- lar Ca2+ concentration and inhibited high voltage-gated Ca2+ channels through different signal transduction pathways.展开更多
The accurate prediction of the strength of rocks after high-temperature treatment is important for the safety maintenance of rock in deep underground engineering.Five machine learning(ML)techniques were adopted in thi...The accurate prediction of the strength of rocks after high-temperature treatment is important for the safety maintenance of rock in deep underground engineering.Five machine learning(ML)techniques were adopted in this study,i.e.back propagation neural network(BPNN),AdaBoost-based classification and regression tree(AdaBoost-CART),support vector machine(SVM),K-nearest neighbor(KNN),and radial basis function neural network(RBFNN).A total of 351 data points with seven input parameters(i.e.diameter and height of specimen,density,temperature,confining pressure,crack damage stress and elastic modulus)and one output parameter(triaxial compressive strength)were utilized.The root mean square error(RMSE),mean absolute error(MAE)and correlation coefficient(R)were used to evaluate the prediction performance of the five ML models.The results demonstrated that the BPNN shows a better prediction performance than the other models with RMSE,MAE and R values on the testing dataset of 15.4 MPa,11.03 MPa and 0.9921,respectively.The results indicated that the ML techniques are effective for accurately predicting the triaxial compressive strength of rocks after different high-temperature treatments.展开更多
The clay mineralogy of 28 sandy-muddy transitional beach(SMT-Beach)sediments and surrounding mountain river sediments along the coasts of southeastern China was systematically investigated to reveal the sediment sourc...The clay mineralogy of 28 sandy-muddy transitional beach(SMT-Beach)sediments and surrounding mountain river sediments along the coasts of southeastern China was systematically investigated to reveal the sediment source-to-sink process variations of such beaches and their morphological indications.The results show that the clay mineral assemblages of these SMT-Beaches mainly comprise of almost equal illite(~30%),kaolinite(~28%),chlorite(~22%),and smectite(~20%)contents.From the surrounding mountain rivers to the SMT-Beaches,clay mineral assemblages show distinct spatial changes characterized by a large decrease(~40%)in kaolinite,whereas the other three clay minerals present relative increases,especially clear for smectite.The muddy sediment sources of SMT-Beaches inferred from the clay mineralogy are mainly derived from nearby mountain rivers coupled with long-distance transport and penetration of the Changjiang River.The sandy sediments of these beaches are predominantly sourced from nearby mountain rivers,the weathering products of surrounding rocks in both mainland and island environments,and erosion of the“Old Red Sand”and“Red Soil Platform”.However,the sandy sediment sources of the SMT-Beaches are largely reduced because of the remarkable decrease in the river fluvial supply associated with intensive human activities such as dam construction and coastal reclamation.Subsequently,the sandy sections of SMT-Beaches present clear erosion and have revealed by both time series remote sensing images and a compilation of published literature.In contrast,the muddy sediment supply of SMT-Beaches is temporarily stable and relatively constant,resulting in the landward migration of the mudflats with relative transgression or accumulation.These findings highlight that the natural evolution processes of SMT-Beaches have been greatly reshaped by intensive human activities.展开更多
MYB proteins play important roles in eukaryotic organisms. In plants, the R1R2R3-type MYB proteins function in cell cycle control. However, whether the R2R3-type MYB protein is also involved in the cell division proce...MYB proteins play important roles in eukaryotic organisms. In plants, the R1R2R3-type MYB proteins function in cell cycle control. However, whether the R2R3-type MYB protein is also involved in the cell division process remains unknown. Here, we report that an R2R3-type transcription factor gene, AtMYB59, is involved in the regulation of cell cycle progression and root growth. The AtMYB59 protein is localized in the nuclei of onion epidermal cells and has transactivation activity. Expression of AtMYB59 in yeast cells suppresses cell proliferation, and the transfor- mants have more nuclei and higher anenpioid DNA content with longer cells. Mutation in the conserved domain of AtMYB59 abolishes its effects on yeast cell growth. In synchronized Arabidopsis cell suspensions, the AtMYB59 gene is specifically expressed in the S phase during cell cycle progression. Expression and promoter-GUS analysis reveals that the AtMYB59 gene is abundantly expressed in roots. Transgenic plants overexpressing AtMYB59 have shorter roots compared with wild-type plants (Arabidopsis accession Col-0), and around half of the mitotic cells in root tips are at metaphase. Conversely, the null mutant myb59-1 has longer roots and fewer mitotic cells at metaphase than Col, suggesting that AtMYB59 may inhibit root growth by extending the metaphase of mitotic cells. AtMYB59 regulates many downstream genes, including the CYCB1;1 gene, probably through binding to MYB-responsive elements. These results support a role forAtMYB59 in cell cycle regulation and plant root growth.展开更多
To investigate the progressive fracture processes around a tunnel triggered by static stress and dynamic disturbance,experiments and numerical simulations were performed.The results show that the spatial distributions...To investigate the progressive fracture processes around a tunnel triggered by static stress and dynamic disturbance,experiments and numerical simulations were performed.The results show that the spatial distributions of acoustic emission(AE)events become very different as lateral pressure coefficients change.The combined effect of static stress and dynamic disturbance causes the damage around the tunnel,and initial stress conditions control the damage morphology.The blast disturbance cannot fundamentally change the damaged area but will deepen the extent of damage and accelerate the failure speed.The more significant the difference between the vertical and horizontal stresses is,the higher the impact on the tunnel by the dynamic disturbance is.The AE activity recovers to a relatively stable state within a short time after the blast and conforms to power-law characteristics.展开更多
Permanent magnet synchronous motors(PMSMs)have been widely employed in the industry. Finite-control-set model predictive control(FCS-MPC), as an advanced control scheme, has been developed and applied to improve the p...Permanent magnet synchronous motors(PMSMs)have been widely employed in the industry. Finite-control-set model predictive control(FCS-MPC), as an advanced control scheme, has been developed and applied to improve the performance and efficiency of the holistic PMSM drive systems. Based on the three elements of model predictive control, this paper provides an overview of the superiority of the FCS-MPC control scheme and its shortcomings in current applications. The problems of parameter mismatch, computational burden, and unfixed switching frequency are summarized. Moreover, other performance improvement schemes, such as the multi-vector application strategy, delay compensation scheme, and weight factor adjustment, are reviewed. Finally, future trends in this field is discussed, and several promising research topics are highlighted.展开更多
Linear induction motors are superior to rotary induction motors in direct drive systems because they can generate direct forward thrust force independent of mechanical transmission.However,due to the large air gap and...Linear induction motors are superior to rotary induction motors in direct drive systems because they can generate direct forward thrust force independent of mechanical transmission.However,due to the large air gap and cut-open magnetic circuit,their efficiency and power factor are quite low,which limit their application in high power drive systems.To attempt this challenge,this work presents a system-level optimization method for a single-sided linear induction motor drive system.Not only the motor but also the control system is included in the analysis.A system-level optimization method is employed to gain optimal steady-state and dynamic performances.To validate the effectiveness of the proposed optimization method,experimental results on a linear induction motor drive are presented and discussed.展开更多
Model predictive controls(MPCs) with the merits of non-linear multi-variable control can achieve better performance than other commonly used control methods for permanent magnet synchronous motor(PMSM) drives.However,...Model predictive controls(MPCs) with the merits of non-linear multi-variable control can achieve better performance than other commonly used control methods for permanent magnet synchronous motor(PMSM) drives.However,the conventional MPCs have various issues,including unsatisfactory steady-state performance,variable switching frequency,and difficult selection of appropriate weighting factors.This paper proposes two different improved MPC methods to deal with these issues.One method is the two-vector dimensionless model predictive torque control(MPTC).Two cost functions(torque and flux) and fuzzy decision-making are used to eliminate the weighting factor and select the first optimum vector.The torque cost function selects a second vector whose duty cycle is determined based on the torque error.The other method is the two-vector dimensionless model predictive current control(MPCC).The first vector is selected the same as in the conventional MPC method.Two separate current cost functions and fuzzy decision-making are used to select the second vector whose duty cycle is determined based on the current error.Both proposed methods utilize the space vector PWM modulator to regulate the switching frequency.Numerical simulation results show that the proposed methods have better steady-state and transient performances than the conventional MPCs and other existing improved MPCs.展开更多
Flowering time is an important agronomic trait that contributes to fitness in plants.However,the genetic basis of flowering time has not been extensively studied in pepper.To understand the genetics underlying floweri...Flowering time is an important agronomic trait that contributes to fitness in plants.However,the genetic basis of flowering time has not been extensively studied in pepper.To understand the genetics underlying flowering time,we constructed an F 2 population by crossing a spontaneous early flowering mutant and a late-flowering pepper line.Using bulked segregant RNA-seq,a major locus controlling flowering time in this population was mapped to the end of chromosome 2.An APETALA2(AP2)homolog(CaFFN)cosegregated with flowering time in 297 individuals of the F 2 population.A comparison between the parents revealed a naturally occurring rare SNP(SNP2T>C)that resulted in the loss of a start codon in CaFFN in the early flowering mutant.Transgenic Nicotiana benthamiana plants with high CaFFN expression exhibited a delay in flowering time and floral patterning defects.On the other hand,pepper plants with CaFFN silencing flowered early.Therefore,the CaFFN gene acts as a flowering repressor in pepper.CaFFN may function as a transcriptional activator to activate the expression of CaAGL15 and miR156e and as a transcriptional repressor to repress the expression of CaAG,CaAP1,CaSEP3,CaSOC1,and miR172b based on a qRT-PCR assay.Direct activation of CaAGL15 by CaFFN was detected using yeast one-hybrid and dual-luciferase reporter assays,consistent with the hypothesis that CaFFN regulates flowering time.Moreover,the CaFFN gene association analysis revealed a significant association with flowering time in a natural pepper population,indicating that the CaFFN gene has a broad effect on flowering time in pepper.Finally,the phylogeny,evolutionary expansion and expression patterns of CaFFN/AP2 homologs were analyzed to provide valuable insight into CaFFN.This study increases our understanding of the involvement of CaFFN in controlling flowering time in pepper,thus making CaFFN a target gene for breeding early maturing pepper.展开更多
A high pressure oil pump has the advantages of compact structure, high working pressure, and it canstill maintain a high efficiency when it is working, so it is very important to analyze its structural strength. A hig...A high pressure oil pump has the advantages of compact structure, high working pressure, and it canstill maintain a high efficiency when it is working, so it is very important to analyze its structural strength. A high-pressure diesel monomer pump is the research object, it is using the finite element software Hypermesh to do thepretreatment of the finite element model, then using Fluent software to analysis the fluid finite element modelwhen it pumped oil to obtain the distribution of oil pressure in the process of pumping oil. And then it is usingAbaqus software to analyze the strength of the related components of the model through mapping oil pressure at thetime of the maximum oil pressure distribution to the model by the structure finite element interpolation, so it canobtain the stress distribution of each component. According to this coupling method to analyze the structuralstrength of high pressure oil pump, it provided the better guidance and reference for the design and optimization ofhigh pressure oil pump.展开更多
The performance of traditional flux switching permanent magnet tubular machine(FSPMTM)are improved by using new material and structure in this paper.The existing silicon steel sheet making for all mover cores or part ...The performance of traditional flux switching permanent magnet tubular machine(FSPMTM)are improved by using new material and structure in this paper.The existing silicon steel sheet making for all mover cores or part of stator cores are replaced by soft magnetic composite(SMC)cores,and the lamination direction of the silicon steel sheet in stator cores have be changed.The eddy current loss of the machine with hybrid cores will be reduced greatly as the magnetic flux will not pass through the silicon steel sheet vertically.In order to reduce the influence of end effect,the unequal stator width design method is proposed.With the new design,the symmetry of the permanent magnet flux linkage has been improved greatly and the cogging force caused by the end effect has been reduced.Both 2-D and 3-D finite element methods(FEM)are applied for the quantitative analysis.展开更多
This paper proposes a new rotary flux switching transverse flux machine with the ability of linear motion(FSTFMaLM),in which both the stator and the rotor cores are made by using soft magnetic composite(SMC)materials....This paper proposes a new rotary flux switching transverse flux machine with the ability of linear motion(FSTFMaLM),in which both the stator and the rotor cores are made by using soft magnetic composite(SMC)materials.With the special design pattern,for the rotary motion model,the proposed machine can combine both the advantages of the flux switching permanent magnet machine(FSPMM)and the transverse flux machine(TFM).It can output with relatively high torque density,and as there is no windings or the magnets on the rotor cores,the proposed machine can operate in the high speed region to improve the output power.With the adoption of the SMC materials,the manufacturing of this machine can be quite easy.By stacking the rotor core together and prolong it with the determined length in the axial direction,in addition with the special control algorithm,the proposed machine can have the ability of the linear motion.In this paper,the operation principle of this machine has been explained and the design methods are also presented.To seek the better performance,the main dimension of the machine is optimized,and for the performance evaluation,the finite element method(FEM)is adopted.The proposed machine can be used for the electric driving systems,robotic systems or other applications where the linear motion ability is required.展开更多
Design and optimization of electrical drive systems often involve simultaneous consideration of multiple objectives that usually contradict to each other and multiple disciplines that normally coupled to each other.Th...Design and optimization of electrical drive systems often involve simultaneous consideration of multiple objectives that usually contradict to each other and multiple disciplines that normally coupled to each other.This paper aims to present efficient system-level multiobjective optimization methods for the multidisciplinary design optimization of electrical drive systems.From the perspective of quality control,deterministic and robust approaches will be investigated for the development of the optimization models for the proposed methods.Meanwhile,two approximation methods,Kriging model and Taylor expansion are employed to decrease the computation/simulation cost.To illustrate the advantages of the proposed methods,a drive system with a permanent magnet synchronous motor driven by a field oriented control system is investigated.Deterministic and robust Pareto optimal solutions are presented and compared in terms of several steady-state and dynamic performances(like average torque and speed overshoot)of the drive system.The robust multiobjective optimization method can produce optimal Pareto solutions with high manufacturing quality for the drive system.展开更多
Statistical prediction is often required in reservoir simulation to quantify production uncertainty or assess potential risks.Most existing uncertainty quantification procedures aim to decompose the input random field...Statistical prediction is often required in reservoir simulation to quantify production uncertainty or assess potential risks.Most existing uncertainty quantification procedures aim to decompose the input random field to independent random variables,and may suffer from the curse of dimensionality if the correlation scale is small compared to the domain size.In this work,we develop and test a new approach,K-means clustering assisted empirical modeling,for efficiently estimating waterflooding performance for multiple geological realizations.This method performs single-phase flow simulations in a large number of realizations,and uses K-means clustering to select only a few representatives,on which the two-phase flow simulations are implemented.The empirical models are then adopted to describe the relation between the single-phase solutions and the two-phase solutions using these representatives.Finally,the two-phase solutions in all realizations can be predicted using the empirical models readily.The method is applied to both 2D and 3D synthetic models and is shown to perform well in the P10,P50 and P90 of production rates,as well as the probability distributions as illustrated by cumulative density functions.It is able to capture the ensemble statistics of the Monte Carlo simulation results with a large number of realizations,and the computational cost is significantly reduced.展开更多
基金The National Natural Science Foundation of China under contract Nos 42076058 and 41930538the National Key Research and Development Program of China under contract No.2022YFC3106104the Scientific Research Foundation of Third Institute of Oceanography,Ministry of Natural Resources under contract Nos 2023023 and 2019017。
文摘As one of the main areas of tropical storm action in the northwestern Pacific Ocean,South China experiences several typhoons each year,and coastal erosion is a problem,making the area a natural testing ground for studying the dynamic geomorphological processes and storm response of promontory-straight coasts.This study is based on three years of topographic data and remote sensing imagery of Gulei Beach and uses topographic profile morphology,single width erosion-accretion and mean change,combined with the Coastsat model to quantify the seasonal and interannual variability and storm response of the beach and to explain the evolution of shoreline change and beach dynamics geomorphology in the last decade.Gulei Beach has been in a state of overall erosion and local accretion for a long time,with relatively obvious cyclical changes;seasonal changes are also obvious,which are mainly characterized by summer accretion and winter erosion,with accretion at the top of the bay and accretion and erosion on the north and south sides of the bay corner,respectively;the seasonal erosion-accretion volume of the beach profile ranges from-80 m3/m to 95.52 m3/m,and the interannual erosion-accretion volume ranges from-69.09 m3/m to 87.31 m3/m.The response of beaches to typhoons with different paths varies greatly depending on the length,slope,orientation and scale of beach development.The large and gently developing Futou beach is less responsive to storms,while the less developed headlands in the southern Gulei Peninsula are more susceptible to disturbance by external factors and respond more strongly to typhoons.Storm distance is more influential than storm intensity.Under the influence of human activities,obvious erosion hotspots develop during normal weather,but storm processes produce redistribution of beach material patterns,and erosion hotspots disappear after storms.The results of this study enrich the theory of beach dynamics geomorphology and provide technical support for disaster prevention and mitigation,as well as ecological restoration of coastal zones.
基金This study was supported by Basic Research Project from Jiangmen Science and Technology Bureau(Grant No.2220002000356)China University of Petroleum(Beijing)(Grand No.2462023BJRC007)The Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110376).
文摘In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture network.It has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture communication.In addition,most of the existing models are solved analytically based on Laplace transform and numerical inversion.Hence,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix depletion.To simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the microfractures.Then,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by integration.Finally,a relationship between oil rate and production time in real-time space is obtained.The new model is verified against classical analytical models.When the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,respectively.Certainly,the new model also has an excellent agreement with the numerical model.The model is then applied to two actual tight oil wells completed in western Canada sedimentary basin.After identifying the flow regime,the solution suitably matches the field production data,and the model parameters are determined.Through these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.
基金This study was supported by the Planning Program of the Health Committee of Ganzhou(2022-1-5)the Key R&D Program of Jiangxi Province(20202BBGL73106)grants from the National Science Foundation of China(81771435).
文摘To the editor:Mood disorders(MD)are serious mental illnesses that commonly affect adolescents,leading to a high incidence of suicidal behaviour.1 In China,the suicide attempt(SA)rate for adolescents with MD is 51.96%,2 and over 500000 adolescent SA are reported annually in the USA due to depression.3 Risk factors for SA include gender,hormone levels,family conflict and,particularly,negative cognitive styles such as rumination.
基金supported by NIH,grant No.GM-63577NNSF,grant No.30571537,No.30271500+1 种基金the National Natural Science Foundation of China,No.30271500,30571537 and 813702462010 National Clinical Key Disciplines Construction Grant from the Ministry of Health of the People’s Republic of China
文摘Activation of cannabinoid receptor type 1 on presynaptic neurons is postulated to suppress neu- ~ ~ ~ 2+ ~ ~ 2+ rotransmlsslon by decreasing Ca reflux through high voltage-gated Ca channels. However, recent studies suggest that cannabinoids which activate cannabinoid receptor type 1 can increase neurotransmitter release by enhancing Ca2+ influx in vitro. The aim of the present study was to investigate the modulation of intracellular Ca2+ concentration by the cannabinoid receptor type 1 agonist anandamide, and its underlying mechanisms. Using whole cell voltage-damp and calcium imaging in cultured trigeminal ganglion neurons, we found that anandamide directly caused Ca2+ influx in a dose-dependent manner, which then triggered an increase of intracellular Ca2+ concentration. The cyclic adenosine and guanosine monophosphate-dependent protein kinase systems, but not the protein kinase C system, were involved in the increased intracellular Ca2+concentration by anandamide. This result showed that anandamide increased intracellu- lar Ca2+ concentration and inhibited high voltage-gated Ca2+ channels through different signal transduction pathways.
基金supported by the High Performance Computing Center of Central South University,China,the High-tech Industry Technology Innovation Leading Plan of Hunan Province,China(No.2020GK2032)the National Natural Science Foundation of China(No.52105419)the Research Fund of the Key Laboratory of High Performance Complex Manufacturing at Central South University,China。
基金We acknowledge the funding support from the National Natural Science Foundation of China(Grant No.51778575)Postdoctoral Science Foundation of China(Grant No.2021M692481)Fundamental Research Funds for the Central Universities of China(Grant No.2042021kf0055).The authors would like to thank the anonymous reviewers and editors for their constructive suggestions which greatly improve the quality of this paper.The authors are also grateful for the permission from Elsevier.
文摘The accurate prediction of the strength of rocks after high-temperature treatment is important for the safety maintenance of rock in deep underground engineering.Five machine learning(ML)techniques were adopted in this study,i.e.back propagation neural network(BPNN),AdaBoost-based classification and regression tree(AdaBoost-CART),support vector machine(SVM),K-nearest neighbor(KNN),and radial basis function neural network(RBFNN).A total of 351 data points with seven input parameters(i.e.diameter and height of specimen,density,temperature,confining pressure,crack damage stress and elastic modulus)and one output parameter(triaxial compressive strength)were utilized.The root mean square error(RMSE),mean absolute error(MAE)and correlation coefficient(R)were used to evaluate the prediction performance of the five ML models.The results demonstrated that the BPNN shows a better prediction performance than the other models with RMSE,MAE and R values on the testing dataset of 15.4 MPa,11.03 MPa and 0.9921,respectively.The results indicated that the ML techniques are effective for accurately predicting the triaxial compressive strength of rocks after different high-temperature treatments.
基金The National Natural Science Foundation of China under contract Nos 41930538,42076211 and 42076058the Scientific Research Foundation of the Third Institute of Oceanography,Ministry of Natural Resources under contract Nos 2022017 and 2019006the China Postdoctoral Science Foundation under contract No.2019M652248.
文摘The clay mineralogy of 28 sandy-muddy transitional beach(SMT-Beach)sediments and surrounding mountain river sediments along the coasts of southeastern China was systematically investigated to reveal the sediment source-to-sink process variations of such beaches and their morphological indications.The results show that the clay mineral assemblages of these SMT-Beaches mainly comprise of almost equal illite(~30%),kaolinite(~28%),chlorite(~22%),and smectite(~20%)contents.From the surrounding mountain rivers to the SMT-Beaches,clay mineral assemblages show distinct spatial changes characterized by a large decrease(~40%)in kaolinite,whereas the other three clay minerals present relative increases,especially clear for smectite.The muddy sediment sources of SMT-Beaches inferred from the clay mineralogy are mainly derived from nearby mountain rivers coupled with long-distance transport and penetration of the Changjiang River.The sandy sediments of these beaches are predominantly sourced from nearby mountain rivers,the weathering products of surrounding rocks in both mainland and island environments,and erosion of the“Old Red Sand”and“Red Soil Platform”.However,the sandy sediment sources of the SMT-Beaches are largely reduced because of the remarkable decrease in the river fluvial supply associated with intensive human activities such as dam construction and coastal reclamation.Subsequently,the sandy sections of SMT-Beaches present clear erosion and have revealed by both time series remote sensing images and a compilation of published literature.In contrast,the muddy sediment supply of SMT-Beaches is temporarily stable and relatively constant,resulting in the landward migration of the mudflats with relative transgression or accumulation.These findings highlight that the natural evolution processes of SMT-Beaches have been greatly reshaped by intensive human activities.
文摘MYB proteins play important roles in eukaryotic organisms. In plants, the R1R2R3-type MYB proteins function in cell cycle control. However, whether the R2R3-type MYB protein is also involved in the cell division process remains unknown. Here, we report that an R2R3-type transcription factor gene, AtMYB59, is involved in the regulation of cell cycle progression and root growth. The AtMYB59 protein is localized in the nuclei of onion epidermal cells and has transactivation activity. Expression of AtMYB59 in yeast cells suppresses cell proliferation, and the transfor- mants have more nuclei and higher anenpioid DNA content with longer cells. Mutation in the conserved domain of AtMYB59 abolishes its effects on yeast cell growth. In synchronized Arabidopsis cell suspensions, the AtMYB59 gene is specifically expressed in the S phase during cell cycle progression. Expression and promoter-GUS analysis reveals that the AtMYB59 gene is abundantly expressed in roots. Transgenic plants overexpressing AtMYB59 have shorter roots compared with wild-type plants (Arabidopsis accession Col-0), and around half of the mitotic cells in root tips are at metaphase. Conversely, the null mutant myb59-1 has longer roots and fewer mitotic cells at metaphase than Col, suggesting that AtMYB59 may inhibit root growth by extending the metaphase of mitotic cells. AtMYB59 regulates many downstream genes, including the CYCB1;1 gene, probably through binding to MYB-responsive elements. These results support a role forAtMYB59 in cell cycle regulation and plant root growth.
基金Project(2017YFC0602904)supported by the National Key Research and Development Program of ChinaProject(51974059)supported by the National Natural Science Foundation of ChinaProject(N180115010)supported by the Fundamental Research Funds for the Central Universities,China。
文摘To investigate the progressive fracture processes around a tunnel triggered by static stress and dynamic disturbance,experiments and numerical simulations were performed.The results show that the spatial distributions of acoustic emission(AE)events become very different as lateral pressure coefficients change.The combined effect of static stress and dynamic disturbance causes the damage around the tunnel,and initial stress conditions control the damage morphology.The blast disturbance cannot fundamentally change the damaged area but will deepen the extent of damage and accelerate the failure speed.The more significant the difference between the vertical and horizontal stresses is,the higher the impact on the tunnel by the dynamic disturbance is.The AE activity recovers to a relatively stable state within a short time after the blast and conforms to power-law characteristics.
基金supported in part by the National Natural Science Foundation of China(51875261)the Postgraduate Research and Practice Innovation Program of Jiangsu Province(KYCX21_3331)+1 种基金the Faculty of Agricultural Equipment of Jiangsu University(NZXB20210103)。
文摘Permanent magnet synchronous motors(PMSMs)have been widely employed in the industry. Finite-control-set model predictive control(FCS-MPC), as an advanced control scheme, has been developed and applied to improve the performance and efficiency of the holistic PMSM drive systems. Based on the three elements of model predictive control, this paper provides an overview of the superiority of the FCS-MPC control scheme and its shortcomings in current applications. The problems of parameter mismatch, computational burden, and unfixed switching frequency are summarized. Moreover, other performance improvement schemes, such as the multi-vector application strategy, delay compensation scheme, and weight factor adjustment, are reviewed. Finally, future trends in this field is discussed, and several promising research topics are highlighted.
文摘Linear induction motors are superior to rotary induction motors in direct drive systems because they can generate direct forward thrust force independent of mechanical transmission.However,due to the large air gap and cut-open magnetic circuit,their efficiency and power factor are quite low,which limit their application in high power drive systems.To attempt this challenge,this work presents a system-level optimization method for a single-sided linear induction motor drive system.Not only the motor but also the control system is included in the analysis.A system-level optimization method is employed to gain optimal steady-state and dynamic performances.To validate the effectiveness of the proposed optimization method,experimental results on a linear induction motor drive are presented and discussed.
文摘Model predictive controls(MPCs) with the merits of non-linear multi-variable control can achieve better performance than other commonly used control methods for permanent magnet synchronous motor(PMSM) drives.However,the conventional MPCs have various issues,including unsatisfactory steady-state performance,variable switching frequency,and difficult selection of appropriate weighting factors.This paper proposes two different improved MPC methods to deal with these issues.One method is the two-vector dimensionless model predictive torque control(MPTC).Two cost functions(torque and flux) and fuzzy decision-making are used to eliminate the weighting factor and select the first optimum vector.The torque cost function selects a second vector whose duty cycle is determined based on the torque error.The other method is the two-vector dimensionless model predictive current control(MPCC).The first vector is selected the same as in the conventional MPC method.Two separate current cost functions and fuzzy decision-making are used to select the second vector whose duty cycle is determined based on the current error.Both proposed methods utilize the space vector PWM modulator to regulate the switching frequency.Numerical simulation results show that the proposed methods have better steady-state and transient performances than the conventional MPCs and other existing improved MPCs.
基金This research was supported by the National Natural Science Foundation of China(31660574)China Postdoctoral Science Foundation(2020M671969)+2 种基金Agricultural Collaborative Innovation Project of Jiangxi Province of China(JXXTCXQN202001)China Agriculture Research System(CARS-24-G-08)Key Research and Development Program of Jiangxi Province of China(20202BBF62002).
文摘Flowering time is an important agronomic trait that contributes to fitness in plants.However,the genetic basis of flowering time has not been extensively studied in pepper.To understand the genetics underlying flowering time,we constructed an F 2 population by crossing a spontaneous early flowering mutant and a late-flowering pepper line.Using bulked segregant RNA-seq,a major locus controlling flowering time in this population was mapped to the end of chromosome 2.An APETALA2(AP2)homolog(CaFFN)cosegregated with flowering time in 297 individuals of the F 2 population.A comparison between the parents revealed a naturally occurring rare SNP(SNP2T>C)that resulted in the loss of a start codon in CaFFN in the early flowering mutant.Transgenic Nicotiana benthamiana plants with high CaFFN expression exhibited a delay in flowering time and floral patterning defects.On the other hand,pepper plants with CaFFN silencing flowered early.Therefore,the CaFFN gene acts as a flowering repressor in pepper.CaFFN may function as a transcriptional activator to activate the expression of CaAGL15 and miR156e and as a transcriptional repressor to repress the expression of CaAG,CaAP1,CaSEP3,CaSOC1,and miR172b based on a qRT-PCR assay.Direct activation of CaAGL15 by CaFFN was detected using yeast one-hybrid and dual-luciferase reporter assays,consistent with the hypothesis that CaFFN regulates flowering time.Moreover,the CaFFN gene association analysis revealed a significant association with flowering time in a natural pepper population,indicating that the CaFFN gene has a broad effect on flowering time in pepper.Finally,the phylogeny,evolutionary expansion and expression patterns of CaFFN/AP2 homologs were analyzed to provide valuable insight into CaFFN.This study increases our understanding of the involvement of CaFFN in controlling flowering time in pepper,thus making CaFFN a target gene for breeding early maturing pepper.
文摘A high pressure oil pump has the advantages of compact structure, high working pressure, and it canstill maintain a high efficiency when it is working, so it is very important to analyze its structural strength. A high-pressure diesel monomer pump is the research object, it is using the finite element software Hypermesh to do thepretreatment of the finite element model, then using Fluent software to analysis the fluid finite element modelwhen it pumped oil to obtain the distribution of oil pressure in the process of pumping oil. And then it is usingAbaqus software to analyze the strength of the related components of the model through mapping oil pressure at thetime of the maximum oil pressure distribution to the model by the structure finite element interpolation, so it canobtain the stress distribution of each component. According to this coupling method to analyze the structuralstrength of high pressure oil pump, it provided the better guidance and reference for the design and optimization ofhigh pressure oil pump.
基金This work was supported in part by the National Natural Science Foundation of China under project 51877065Hebei Province Education Department Youth Talent Leading Project under grant BJ2018037in part by the State Key Laboratory of Reliability and Intelligence of Electrical Equipment under grant EERIKF2018005.
文摘The performance of traditional flux switching permanent magnet tubular machine(FSPMTM)are improved by using new material and structure in this paper.The existing silicon steel sheet making for all mover cores or part of stator cores are replaced by soft magnetic composite(SMC)cores,and the lamination direction of the silicon steel sheet in stator cores have be changed.The eddy current loss of the machine with hybrid cores will be reduced greatly as the magnetic flux will not pass through the silicon steel sheet vertically.In order to reduce the influence of end effect,the unequal stator width design method is proposed.With the new design,the symmetry of the permanent magnet flux linkage has been improved greatly and the cogging force caused by the end effect has been reduced.Both 2-D and 3-D finite element methods(FEM)are applied for the quantitative analysis.
基金This work was supported in part by the National Natural Science Foundation of China under project 51877065Hebei Province Education Department Youth Talent Leading Project under grant BJ2018037.
文摘This paper proposes a new rotary flux switching transverse flux machine with the ability of linear motion(FSTFMaLM),in which both the stator and the rotor cores are made by using soft magnetic composite(SMC)materials.With the special design pattern,for the rotary motion model,the proposed machine can combine both the advantages of the flux switching permanent magnet machine(FSPMM)and the transverse flux machine(TFM).It can output with relatively high torque density,and as there is no windings or the magnets on the rotor cores,the proposed machine can operate in the high speed region to improve the output power.With the adoption of the SMC materials,the manufacturing of this machine can be quite easy.By stacking the rotor core together and prolong it with the determined length in the axial direction,in addition with the special control algorithm,the proposed machine can have the ability of the linear motion.In this paper,the operation principle of this machine has been explained and the design methods are also presented.To seek the better performance,the main dimension of the machine is optimized,and for the performance evaluation,the finite element method(FEM)is adopted.The proposed machine can be used for the electric driving systems,robotic systems or other applications where the linear motion ability is required.
文摘Design and optimization of electrical drive systems often involve simultaneous consideration of multiple objectives that usually contradict to each other and multiple disciplines that normally coupled to each other.This paper aims to present efficient system-level multiobjective optimization methods for the multidisciplinary design optimization of electrical drive systems.From the perspective of quality control,deterministic and robust approaches will be investigated for the development of the optimization models for the proposed methods.Meanwhile,two approximation methods,Kriging model and Taylor expansion are employed to decrease the computation/simulation cost.To illustrate the advantages of the proposed methods,a drive system with a permanent magnet synchronous motor driven by a field oriented control system is investigated.Deterministic and robust Pareto optimal solutions are presented and compared in terms of several steady-state and dynamic performances(like average torque and speed overshoot)of the drive system.The robust multiobjective optimization method can produce optimal Pareto solutions with high manufacturing quality for the drive system.
基金the funding supported by Beijing Natural Science Foundation(Grant No.3222037)the PetroChina Innovation Foundation(Grant No.2020D-5007-0203)by the Science Foundation of China University of Petroleum,Beijing(Nos.2462021YXZZ010,2462018QZDX13,and 2462020YXZZ028)
文摘Statistical prediction is often required in reservoir simulation to quantify production uncertainty or assess potential risks.Most existing uncertainty quantification procedures aim to decompose the input random field to independent random variables,and may suffer from the curse of dimensionality if the correlation scale is small compared to the domain size.In this work,we develop and test a new approach,K-means clustering assisted empirical modeling,for efficiently estimating waterflooding performance for multiple geological realizations.This method performs single-phase flow simulations in a large number of realizations,and uses K-means clustering to select only a few representatives,on which the two-phase flow simulations are implemented.The empirical models are then adopted to describe the relation between the single-phase solutions and the two-phase solutions using these representatives.Finally,the two-phase solutions in all realizations can be predicted using the empirical models readily.The method is applied to both 2D and 3D synthetic models and is shown to perform well in the P10,P50 and P90 of production rates,as well as the probability distributions as illustrated by cumulative density functions.It is able to capture the ensemble statistics of the Monte Carlo simulation results with a large number of realizations,and the computational cost is significantly reduced.