Objective: The aim of the study was to investigate the association of esophageal squamous cell carcinoma (ESCC) genetic susceptibility with the single nucleotide polymorphism (SNP) rs679620 (-Lys45Glu-) in exon 2 of t...Objective: The aim of the study was to investigate the association of esophageal squamous cell carcinoma (ESCC) genetic susceptibility with the single nucleotide polymorphism (SNP) rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene, and the population in high incidence region of Henan (China) was selected for exploring the mechanism by case-control study. Methods: The mmp3 SNP was genotyped by PCR-RFLP analysis in total 605 cases of Henan population, in which there were 227 ESCC cases and 197 controls of An-yang in Henan plus 181 controls of emigrants in Hubei from Xi-chuan of Henan, China. Results: The statistic data showed that G/G and G/A genotype frequencies of SNP rs679620 were significantly different between the controls of emigrants of Xi-chuan in Hubei and controls of An-yang in Henan (P < 0.01) also the ESCC cases of An-yang in Henan (P < 0.01), respectively. Conclusion: This study suggests that the SNP rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene might be associated with ESCC genetic susceptibility.展开更多
Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR dev...Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications.展开更多
基金Supported by a grant from the Natural Sciences Foundation of State Ethnic Affairs Commission of China (No. 07ZN09)
文摘Objective: The aim of the study was to investigate the association of esophageal squamous cell carcinoma (ESCC) genetic susceptibility with the single nucleotide polymorphism (SNP) rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene, and the population in high incidence region of Henan (China) was selected for exploring the mechanism by case-control study. Methods: The mmp3 SNP was genotyped by PCR-RFLP analysis in total 605 cases of Henan population, in which there were 227 ESCC cases and 197 controls of An-yang in Henan plus 181 controls of emigrants in Hubei from Xi-chuan of Henan, China. Results: The statistic data showed that G/G and G/A genotype frequencies of SNP rs679620 were significantly different between the controls of emigrants of Xi-chuan in Hubei and controls of An-yang in Henan (P < 0.01) also the ESCC cases of An-yang in Henan (P < 0.01), respectively. Conclusion: This study suggests that the SNP rs679620 (-Lys45Glu-) in exon 2 of the mmp3 gene might be associated with ESCC genetic susceptibility.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.61904077,61801210,91833302,11574080,61904080)the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20180686,BK20190670,BK20161008)+2 种基金the funding for“Distinguished professors”and“High-level talents in six industries”of Jiangsu Province(Grant No.XYDXX-021)the Fundamental Research Funds for the Central Universitiesthe start-up foundation of Nanjing Tech University and Northwestern Polytechnical University.
文摘Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications.
