Research and Application of Recycled Concrete Technology in Prefabricated Buildings

The utilization of waste concrete as a raw material for recycled concrete in the domain of prefabricated components is garnering greater interest.This paper delineates and examines the concept,categorization,methodologies of preparation,applicable sectors,and evaluative metrics of recycled concrete technology,highlighting its prospective benefits.Nonetheless,for the successful integration of recycled concrete technology into prefabricated component applications,it is imperative to systematically enhance its physical,mechanical,and attributes,as well as its environmental efficacy.Moreover,to foster the continued advancement of recycled concrete technology,innovative initiatives,standardization,educational programs,demonstration projects,and collaborative efforts are crucial to promote broader adoption and realize improved outcomes within the realm of prefabricated components.In conclusion,recycled concrete technology is poised to play a pivotal role in prefabricated construction,offering robust support for propelling the construction industry towards a sustainable future.

Development and Application of Modern Building Ceramic Materials

With the increasing demand for sustainable building design,modern building ceramic materials are one of the key factors driving innovation and development in the field of architecture,thanks to their excellent performance and environmentally friendly properties.The aim of this study is to provide an insight into the development and application of building ceramic materials in modern architecture,and to assess the contribution of material innovation to architectural design and sustainability goals by synthesising and analysing recent technological advances and case studies in this field.This study adopts a systematic literature review approach to screen and analyse a large number of academic articles and practical project reports on material innovation in building ceramics.Comparative analyses of different material properties,advances in production processes and the effects of their application in real building projects reveal the potential of building ceramic materials to improve the energy efficiency,extend the service life and enhance the aesthetic design of buildings.The findings show that the environmental and energy issues facing traditional building materials,such as improved thermal efficiency and a reduction in the overall carbon footprint of buildings,can be effectively addressed through the use of new building ceramic materials and technologies.In addition,the innovative use of architectural ceramics provides architects with more design flexibility,enabling them to create architectural works that are both aesthetically pleasing and functional.In the concluding section,the paper highlights the importance of continuing to explore technological innovations in building ceramic materials and how these innovations can contribute to a more sustainable and environmentally friendly building industry.Future research should further explore new areas of application for ceramic materials and how interdisciplinary collaboration can accelerate the practical application of these material technologies.

Choledochoscope manometry about different drugs on the Sphincter of Oddi

AIM: To assess the effects of H2-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents on the human Sphincter of Oddi (SO) motility by choledochoscope manometry. METHODS: One hundred and seventy-five patients with T tube installed after cholecystectomy and choledochotomy were assessed by choledochoscope manometry. They were randomly assigned into groups of H2-receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents. The Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duodenal pressure (DP), and common bile duct pressure (CBDP) were scored and analyzed. RESULTS: SOBP and SOCA were significantly decreased after Cimetidine administration, and no statistical difference was seen in the Famotidine group. In the Gabexate mesilate group, SOBP had decreased significantly. In the Ulinastatin group, SOCA decreased when Ulinastatin was given at the rate of 2500 U/min; when Ulinastatin administration was raised to 5000 U/ min, SOBP, SOF and SOCA all experienced a fall. SOBP and SOCA for Domperidone and SOCA for Mosapride groups all decreased distinctly after administration. CONCLUSION: The regular dosage of Cimetidine showed an inhibitory effect on the motility of SO, whileFamotidine had no obvious effects otherwise. Gabnexata mesilate, Ulinastatin and gastro kinetic agents also showed inhibitory effects on the SO motility.

Nitrogen-doped hierarchical porous carbon from polyaniline/silica self-aggregates for supercapacitor

In this paper, nitrogen-doped hierarchical porous carbon(N-HPC) was prepared from polyaniline(PANI)/silica self-aggregates. H-bonding between N\\H groups in aniline/PANI and \\OH groups in nano silica template led to a self-assembly type, which enabled the formation of uniform N-HPC nanoparticles. Silica self-aggregates provided macroporous channels resulted in a decreased diffusion distance. After removing the hard template,the N-HPC had a high surface area(899 m^2·g^(-1)). Owing to two co-existed synergetic energy-storage mechanisms and the hierarchical porous structure, the obtained N-HPC exhibited a high specific capacitance of 218.75 F·g^(-1) at 0.5 A·g^(-1), compared with the nonporous nitrogen-doped carbon(N-C) derived from pure PANI. Moreover, the N-HPC electrode demonstrated excellent cycle life, retaining 99% of its initial specific capacitance after 1000 cycles.

Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps

瞄准：与胆石或胆囊息肉在病人的胆囊纸巾检测垂体 adenylate 激活 cyclase 多肽受体 1 的表示(VPCAP1-R ) 和 VPCAP2-R mRNA。方法：在胆囊纸巾的 VPCAP1-R 和 VPCAP2-R mRNA 的表示被反向的抄写聚合酶链反应(RT-PCR ) 与胆石，有胆囊息肉的 8 个病人和肝移植的 7 个施主在 25 个病人检测。结果：当在控制组( 1.15+/-0.23 )的 VPCAP1-R mRNA 表达式水平不在胆囊与那显然不同时，在控制组( 1.09+/-0.58 )的 VPCAP2-R mRNA 表达式水平在胆囊息肉组( 1.64+/-0.56 )和胆石组( 1.55+/-0.45 )( P【0.05 )是比那低的息肉组( 1.28+/-0.56 )和胆石组( 1.27+/-0.38 )。结论：在胆囊织物的 VPCAP2-R mRNA 的反常表示可以在胆囊石头和胆囊息肉的形成起一个作用。

结肠癌组织中ERRα和ERRβ的表达水平及其临床意义

目的检测结肠癌组织中雌激素相关受体α(ERRα)和ERRβ的表达水平,分析其与结肠癌临床病理特征的关系,并探讨其临床意义。方法选取手术切除的结肠癌组织及其癌旁正常结肠组织标本各63例,采用免疫组织化学法检测ERRα和ERRβ蛋白阳性表达,观察其与结肠癌临床病理特征的关系,探讨两者相关性。结果 ERRα和ERRβ蛋白表达于结肠癌及癌旁组织细胞核,在癌组织中高表达,癌旁组织中弱表达,结肠癌组织中ERRα和ERRβ蛋白的阳性表达率高于癌旁组织(P<0.05)。ERRα和ERRβ蛋白的阳性表达与肿瘤浸润深度、远处转移、血管浸润、TNM分期及肿瘤分化程度有关(P<0.05)。Spearman rank相关分析结果显示,结肠癌组织中ERRα与ERRβ蛋白的阳性表达率呈正相关(P<0.05)。结论 ERRα和ERRβ在结肠癌组织中高表达,与结肠癌不良预后临床病理特征具有相关性,两者可能共同调控结肠癌的恶性行为。

Anomalous Hall Effect in Layered Ferrimagnet MnSb2Te4

We report on low-temperature electron transport properties of MnSb2Te4,a candidate of ferrimagnetic Weyl semimetal.Long-range magnetic order is manifested as a nearly square-shaped hysteresis loop in the anomalous Hall resistance,as well as sharp jumps in the magnetoresistance.At temperatures below 4K,a lnT-type upturn appears in the temperature dependence of longitudinal resistance,which can be attributed to the electron-electron interaction(EEI),since the weak localization can be excluded by the temperature dependence of magnetoresistance.Although the anomalous Hall resistance exhibits a similar lnT-type upturn in the same temperature range,such correction is absent in the anomalous Hall conductivity.Our work demonstrates that MnSb2Te4 microflakes provide an ideal system to test the theory of EEI correction to the anomalous Hall effect.

MicroRNA-93及Tspan1在结肠癌中的表达及其临床病理意义

目的探讨microRNA-93(miR-93)及Tspan1在结肠癌组织及细胞中的表达及其临床病理意义,预测两者的靶向调控关系。方法选取手术切除结肠癌组织及对应癌旁组织74例,人结肠癌细胞株(SW480、SW620、HCT116、CaCo-2、LoVo、HT29)及正常人结肠上皮细胞株(FHC),分别采用qRT-PCR及Western blotting检测miR-93、Tspan1 mRNA及Tspan1蛋白表达,观察两者在不同临床病理特征患者的表达差异,Pearson法分析miR-93与Tspan1 mRNA的相关性,采用TargetScan及GeneCard软件预测两者的靶向调控关系。结果与癌旁组织比较,miR-93在结肠癌组织中表达降低(P<0.05),Tspan1 mRNA及蛋白在结肠癌组织中表达升高(P<0.05);与正常人结肠上皮细胞比较,miR-93在结肠癌细胞株中表达降低(P<0.05),Tspan1 mRNA及蛋白在结肠癌细胞株中表达升高(P<0.05);miR-93在远处转移、淋巴结转移阳性、血管浸润阳性及高TNM分期患者中低表达(P<0.05),Tspan1 mRNA在远处转移、淋巴结转移阳性、血管浸润阳性及高TNM分期患者中高表达(P<0.05)。Pearson法相关性分析显示,miR-93与Tspan1 mRNA表达呈负相关[r=-0.735(95% CI:-0.855,-0.535),P=0.000]。生物信息学预测,miR-93及Tspan1在3’-UTR区可能具有靶向调控关系。结论 miR-93在结肠癌中低表达,Tspan1在结肠癌中高表达,miR-93及Tspan1具有靶向调控关系,两者可能成为结肠癌的肿瘤标志物或预测因子。

Pressureless reactive sintering mechanism of nanocrystalline Bi_2O_3-Y_2O_3 solid electrolyte

The nanocrystalline Bi2O3-Y2O3 solid electrolyte material was synthesized by pressureless reactive sintering process with Bi2O3 and Y2O3 nano mixed powder as raw materials, which was prepared by a chemical coprecipitation process. The study on the behavior of nano δ-Bi2O3 formation and its grain growth showed that the solid solution reaction of Y2O3 and δ-Bi2O3 to form δ-Bi2O3 occurs mainly in the initial stage of sintering process, and nano δ-Bi2O3 crystal grains grow approximately following the rule of paracurve （（D-D0）^2=K.t） during sintering process. After sintered at 600℃ for 2 h, the samples could reach above 96% in relative density and have dense microstructure with few remaining pores, the δ-Bi2O3 grains are less than 100 nm in size.

Growth and transport properties of topological insulator Bi2Se3 thin film on a ferromagnetic insulating substrate

Exchange coupling between topological insulator and ferromagnetic insulator through proximity effect is strongly attractive for both fundamental physics and technological applications. Here we report a comprehensive investigation on the growth behaviors of prototype topological insulator Bi2Se3 thin film on a single-crystalline LaCoO3 thin film on SrTiO3 substrate, which is a strain-induced ferromagnetic insulator. Different from the growth on other substrates, the Bi2Se3 films with highest quality on LaCoO3 favor a relatively low substrate temperature during growth. As a result, an inverse dependence of carrier mobility with the substrate temperature is found. Moreover, the magnetoresistance and coherence length of weak antilocalization also have a similar inverse dependence with the substrate temperature, as revealed by the magnetotransport measurements. Our experiments elucidate the special behaviors in Bi2Se3/LaCoO3 heterostructures, which provide a good platform for exploring related novel quantum phenomena, and are inspiring for device applications.

Power and Voltage Control Based on DC Offset Injection for Bipolar Low-voltage DC Distribution System

The bipolar low-voltage DC(LVDC) distribution system has become a prospective solution to better integration of renewables and improvement of system efficiency and reliability. However, it also faces the challenge of power and voltage imbalance between two poles. To solve this problem, an interface converter with bipolar asymmetrical operating capabilities is applied in this paper. The steady-state models of the bipolar LVDC distribution system equipped with this interface converter in the gridconnected mode and off-grid mode are analyzed. A control scheme based on DC offset injection at the secondary side of the interface converter is proposed, enabling the bipolar LVDC distribution system to realize the unbalanced power transfer between two poles in the grid-connected mode and maintain the inherentpole voltage balance in the off-grid mode. Furthermore, this paper also proposes a primary-side DC offset injection control scheme according to the analysis of the magnetic circuit model, which can eliminate the DC bias flux caused by the secondaryside DC offset. Thereby, the potential core magnetic saturation and overcurrent issues can be prevented, ensuring the safety of the interface converter and distribution system. Detailed simulations based on the proposed control scheme are conducted to validate the function of power and voltage balance under the operation conditions of different DC loads.

Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice

Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly population.Given the increased incidence of cancer and the population ageing trend globally,it is very important to explore how ageing impairs tissue wound healing and spontaneous cancer.In a murine model of DSS-induced acute colitis and AOM/DSS-induced colitis-associated cancer(CAC),we found ageing significantly decreases intestinal wound healing and simultaneous CAC initiation,although ageing does not affect the incidence of AOM-induced,sporadic non-inflammatory CRC.Mechanistically,reduced fibroblasts were observed in the colitis microenvironment of ageing mice.Through conditional lineage tracing,an important source of fibroblasts potentially derived from intestinal smooth muscle cells(ISMCs)was identified orchestrating intestinal wound healing and CAC initiation in young mice.However,the number of transformed fibroblasts from ISMCs significantly decreased in ageing mice,accompanied by decreased intestinal wound healing and decreased CAC initiation.ISMCs-fibroblasts transformation in young mice and reduction of this transformation in ageing mice were also confirmed by ex-vivo intestinal muscular layer culture experiments.We further found that activation of YAP/TAZ in ISMCs is required for the transformation of ISMCs into fibroblasts.Meanwhile,the reduction of YAP/TAZ activation in ISMCs during intestinal wound healing was observed in ageing mice.Conditional knockdown of YAP/TAZ in ISMCs of young mice results in reduced fibroblasts in the colitis microenvironment,decreased intestinal wound healing and decreased CAC initiation,similar to the phenotype of ageing mice.In addition,the data from intestine samples derived from inflammatory bowel disease(IBD)patients show that activation of YAP/TAZ also occurs in ISMCs from these patients.Collectively,our work reveals an important role of the ageing stromal microenvironment in intestinal wound healing and CAC initiation.Furthermore,our work also identified a potential source of fibroblasts involved in colitis and CAC.

高强度钢材钢结构抗震研究进展综述

随着屈服强度的提高,高强度结构钢材的屈强比增大,断后伸长率减小,由于缺少相应规范条文,其在抗震设防地区的应用受到限制。从材料、构件和结构三个层面出发,总结了近年来国内外学者针对高强度钢材钢结构抗震性能的研究成果。重点包括:材料的静力拉伸力学性能、循环本构和极低周疲劳性能;柱、梁和连接节点的抗震性能;高强钢结构框架的抗震性能等内容。最后,对高强钢钢结构抗震性能的进一步研究工作进行了展望。

Biomimetic Corrugated Silicon Nanocone Arrays for Self-Cleaning Antireflection Coatings

Corrugated silicon nanocone(SiNC)arrays have been fabricated on a silicon wafer by two polystyrene-sphere-monolayer-masked etching steps in order to create high-performance antireflective coatings.The reflectance was reduced from above 35%to less than 0.7%in the range 400-1050 nm,and it remained below 0.5%at incidence angles up to 70°at 632.8 nm for both s-and p-polarized light.The fluorinated corrugated SiNC array surface exhibits superhydrophobic properties with a water contact angle of 164°.

Fabrication of 3D biomimetic composite coating with broadband antireflection, superhydrophilicity, and double p-n heterojunctions

The traditional single material with two-dimensional （2D） biomimetic moth-eye structures is limited by its narrowband antireflection and single functional capability. To overcome these disadvantages, we exploited wet etching and hydrothermal synthesis coupled with chemical oxidation for fabricating a three- dimensional （3D） biomimetic moth-eye coating with ternary materials （polypyrrole nanoparticles, TiO2 nanorods, and Si micropyramids, i.e., PPy/TiOa/Si-p）. This coating reduced the reflectivity to 〈4% at wavelengths ranging from 200 to 2,300 nm and exhibited remarkable superhydrophilidty with a low water contact angle of 1.8°. Moreover, the composite coating had double p-n heterojunctions, allowing the high-efficiency separation of photogenerated carriers. The photo- current density of PPy/TiO2/Si-p was more than three times higher than that of TiO2/Si-p at a positive potential of 1.5 V. The proposed method provides a means to enhance solar energy conversion.

Tuning of the active phase structure and hydrofining performance of alumina-supported tri-metallic WMoNi catalysts via phosphorus incorporation

The effects of phosphorus on the structure and hydrofining performance of tri-metallic WMoNi/Al2O3 catalysts prepared with W/Mo-based hybrid precursor nanocrystals were investigated. The incorporation of phosphorus weakened the metal-support interactions （MSIs） and facilitated the formation of more synergetic NiWMoS phases with higher stacks. Catalytic tests using a fluid catalytic cracking diesel fuel showed that the changes in the MSIs and the morphology of the active phases had a more positive effect on the hydrodenitrogenation activity than on the hydrodesulfurization activity. In contrast, when phosphorus was incorporated into a tri-metallic WMoNiP/Al2O3 catalyst prepared by a conventional incipient impregnation method, the MSIs decreased causing aggregation of the metal species which resulted in poorer hydrofining performance of the catalyst. These results show that incorporating phosphorus into a WMoNi/Al2O3 catalyst can finely tune the structure of the active phase to enhance the hydrogenation and hydrodenitrogenation activity of the resulting tri-metallic catalyst.

A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity

Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance,such as program death-1(PD-1/PD-L1)pathway in the tumor environment.However,the determinants of response to anti-PD-1 monoclonal antibodies(mAbs)treatment remain incompletely understood.In murine models,PD-1 blockade alone fails to induce effective immune responses to poorly immunogenic tumors,but is successful when combined with additional interventions,such as cancer vaccines.Novel cancer vaccines combined with antibody may offer promising control of cancer development and progression.In this investigation,we generated a novel tumor cell vaccine simultaneously expressing anti-PD-1 mAbs and granulocyte-macrophage colony stimulating factor(GM-CSF)in CT26 colon cancer and B16-F10 melanoma.The antitumor effect of the vaccine was verified by therapeutic and adoptive animal experiments in vivo.The antitumor mechanism was analyzed using Flow cytometry,Elispot and in vivo intervention approaches.The results showed that tumor cell vaccine secreting PD-1 neutralizing antibodies and GM-CSF induced remarkable antitumor immune effects and prolonged the survival of tumor-bearing animals compared with animals treated with either PD-1 mAbs or GM-CSF alone.Antitumor effects and prolonged survival correlated with strong antigen-specific T-cell responses by analyzing CD11c^(+)CD86^(+)DC,CD11b^(+)F4/80^(+)MΦcells,increased ratio of Teff/Treg in the tumor microenvironment,and higher secretion levels of Th1 proinflammatory cytokines in serum.Furthermore,the results of ELISPOT and in vivo blocking strategies further confirmed that the antitumor immune response is acquired by CD4 and CD8 T immune responses,primarily dependent on CD4 Th1 immune response,not NK innate immune response.The combination of PD-1 blockade with GM-CSF secretion potency creates a novel tumor cell vaccine immunotherapy,affording significantly improved antitumor responses by releasing the state of immunosuppressive microenvironment and augmenting the tumor-reactive T-cell responses.

On the anomalous low-resistance state and exceptional Hall component in hard-magnetic Weyl nanoflakes

Magnetic topological materials, which combine magnetism and topology, are expected to host emerging topological states and exotic quantum phenomena. In this study, with the aid of greatly enhanced coercive fields in high-quality nanoflakes of the magnetic Weyl semimetal Co_(3)Sn_(2)S_(2), we investigate anomalous electronic transport properties that are difficult to reveal in bulk Co_(3)Sn_(2)S_(2) or other magnetic materials. When the magnetization is antiparallel to the applied magnetic field, the low longitudinal resistance state occurs, which is in sharp contrast to the high resistance state for the parallel case. Meanwhile, an exceptional Hall component that can be up to three times larger than conventional anomalous Hall resistivity is also observed for transverse transport. These anomalous transport behaviors can be further understood by considering nonlinear magnetic textures and the chiral magnetic field associated with Weyl fermions, extending the longitudinal and transverse transport physics and providing novel degrees of freedom in the spintronic applications of emerging topological magnets.

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

Analysis and stabilization control of a voltage source controlled wind farm under weak grid conditions

This paper investigates and discusses the interaction stability issues of a wind farm with weak grid connections,where the wind turbines(WTs)are controlled by a new type of converter control strategy referred to as the voltage source(VS)control.The primary intention of the VS control method is to achieve the high-quality inertial response capability of a single WT.However,when it is applied to multiple WTs within a wind farm,its weakgrid performance regarding the stability remains concealed and needs to be clarified.To this end,a frequency domain model of the wind farm under the VS control is first developed.Based on this model and the application of a stability margin quantification index,not only the interactions between the wind farm and the weak grid but also those among WTs will be systematically assessed in this paper.A crucial finding is that the inertial response of VS control has negative impacts on the stability margin of the system,and the dominant instability mode is more related to the interactions among the WTs rather than the typical grid-wind farm interaction.Based on this knowledge,a stabilization control strategy is then proposed,aiming for stability improvements of VS control while fulfilling the demand of inertial responses.Finally,all the results are verified by time-domain simulations in power systems computer aided design/electromagnetic transients including DC(PSCAD/EMTDC).