BACKGROUND Oral cancer(OC)is the most common malignant tumor in the oral cavity,and is mainly seen in middle-aged and elderly men.At present,OC is mainly treated clinically by surgery or combined with radiotherapy and...BACKGROUND Oral cancer(OC)is the most common malignant tumor in the oral cavity,and is mainly seen in middle-aged and elderly men.At present,OC is mainly treated clinically by surgery or combined with radiotherapy and chemotherapy;but recently,more and more studies have shown that the stress trauma caused by surgery and the side effects of radiotherapy and chemotherapy seriously affect the prognosis of patients.AIM To determine the significance of 125I radioactive seed implantation on growth differentiation factor 11(GDF11)and programmed death receptor-1(PD-1)during treatment of OC.METHODS A total of 184 OC patients admitted to The Second Affiliated Hospital of Jiamusi University from May 2015 to May 2017 were selected as the research subjects for prospective analysis.Of these patients,89 who received 125I radioactive seed implantation therapy were regarded as the research group(RG)and 95 patients who received surgical treatment were regarded as the control group(CG).The clinical efficacy,incidence of adverse reactions and changes in GDF11 and PD-1 before treatment(T0),2 wk after treatment(T1),4 wk after treatment(T2)and 6 wk after treatment(T3)were compared between the two groups.RESULTS The efficacy and recurrence rate in the RG were better than those in the CG(P<0.05),while the incidence of adverse reactions and survival rate were not different.There was no difference in GDF11 and PD-1 between the two groups at T0 and T1,but these factors were lower in the RG than in the CG at T2 and T3(P<0.05).Using receiver operating characteristic(ROC)curve analysis,GDF11 and PD-1 had good predictive value for efficacy and recurrence(P<0.001).CONCLUSION 125I radioactive seed implantation has clinical efficacy and can reduce the recurrence rate in patients with OC.This therapy has marked potential in clinical application.The detection of GDF11 and PD-1 in patients during treatment showed good predictive value for treatment efficacy and recurrence in OC patients,and may be potential targets for future OC treatment.展开更多
Chlorinated organic residual liquid is produced from the distillation process of new refrigerants production. It is difficult to be treated by traditional water treatment process and incineration process. In this stud...Chlorinated organic residual liquid is produced from the distillation process of new refrigerants production. It is difficult to be treated by traditional water treatment process and incineration process. In this study, a carbonization process at atmospheric pressure was used to convert this residual liquid to carbonaceous product and organic gas in 2 h at 230℃ or 260℃. The carbonaceous product was characterized by scanning electron microscope, Fourier-transform infrared spectrometer and thermo gravimetric analysis. The element composition and the high heat value of these products were similar to anthracite and lignite, respectively, showing that they could be used as alternative fuels. The components of organic gas were analyzed using gas chromatography-mass spectrometry and the gas had potential for incineration.展开更多
Nonylphenol polyethoxylates (NPEOs) are widely used as nonionic surfactants in many industry fields. High concentration NPEOs waste water is produced in some production processes. It is often treated to realize reduct...Nonylphenol polyethoxylates (NPEOs) are widely used as nonionic surfactants in many industry fields. High concentration NPEOs waste water is produced in some production processes. It is often treated to realize reduction by distillation. Therefore, NPEOs waste liquid with higher concentration is produced and it is difficult to be treated by traditional water treatment process. In this study, hydrothermal carbonization process was used to convert NPEOs waste liquid to carbonaceous product (hydrochar) with sulfuric acid as additive in 24 h at 200°C. The hydrochar was characterized by scanning electron microscope, Fourier-transform infrared spectrometer and thermogravimetric analysis. The element composition and the high heat value of the hydrochar were similar to lignite, showing that it could be used as an alternative fuel.展开更多
A"once-in-a-millennium"super rainstorm battered Zhengzhou,central China,from 07/17/2021 to 07/22/2021(named"7.20"Zhengzhou rainstorm).It killed 398 people and caused billions of dollars in damage.A...A"once-in-a-millennium"super rainstorm battered Zhengzhou,central China,from 07/17/2021 to 07/22/2021(named"7.20"Zhengzhou rainstorm).It killed 398 people and caused billions of dollars in damage.A pressing question is whether rainstorms of this intensity can be effectively documented by geological archives to understand better their historical variabilities beyond the range of meteorological data.Here,four land snail shells were collected from Zhengzhou,and weekly to daily resolved snail shellδ^(18)O records from June to September of 2021 were obtained by gas-source mass spectrometry and secondary ion mass spectrometry.The daily resolved records show a dramatic negative shift between 06/18/2021 and 09/18/2021,which has been attributed to the"7.20"Zhengzhou rainstorm.Moreover,the measured amplitude of this shift is consistent with the theoretical value estimated from the flux balance model and instrumental data for the"7.20"Zhengzhou rainstorm.Our results suggest that the ultra-high resolutionδ^(18)O of land snail shells have the potential to reconstruct local synoptic scale rainstorms quantitatively,and thus fossil snail shells in sedimentary strata can be valuable material for investigating the historical variability of local rainstorms under different climate backgrounds.展开更多
Adenine is an essential building block of genetic material and a range of coenzymes.Chemical probes containing an adenine moiety have been used in kinase profiling studies in cell lysates.Here we report that adenine-d...Adenine is an essential building block of genetic material and a range of coenzymes.Chemical probes containing an adenine moiety have been used in kinase profiling studies in cell lysates.Here we report that adenine-derived small-molecule probes with an activated ester reactive group can covalently modify a conserved lysine residue of protein kinases and capture a number of nucleotide-binding proteins within living cells.展开更多
Application of X-ray fluorescence core-scanning(XRF-CS) on both marine and lake sediments has achieved remarkable results. However, its application has not been widely extended to the research on speleothems. In this ...Application of X-ray fluorescence core-scanning(XRF-CS) on both marine and lake sediments has achieved remarkable results. However, its application has not been widely extended to the research on speleothems. In this study, we measure the Sr abundance and the Sr/Ca ratios of three stalagmites(two aragonite stalagmites, one calcite stalagmite) using the state-of-the-art fourth-generation Avaatech high-resolution XRF core scanner. Through comparisons among different scan paths and among different scan resolutions, as well as comparisons with inductively coupled plasma optical emission spectrometer(ICP-OES), Itrax XRF, and Artax XRF results, we confirm that the Avaatech XRF core scanner could precisely, quickly, and nondestructively analyze the high-resolution Sr abundance of speleothems. Furthermore, we combine the stalagmite δ^(18)O records to explore the paleoclimatic significance of the measured stalagmite Sr/Ca.展开更多
Ibuprofen(IBU)is widely used in the world as anti-inflammatory drug,which posed health risk to the environment.A bacterium capable of degrading IBU was isolated from activated sludge in a sewage treatment plant.Accord...Ibuprofen(IBU)is widely used in the world as anti-inflammatory drug,which posed health risk to the environment.A bacterium capable of degrading IBU was isolated from activated sludge in a sewage treatment plant.According to its morphological,physiologic,and biochemical characteristics,as well as 16S rRNA sequence analysis,the strain was identified as Serratia marcescens BL1(BL1).Degradation of IBU required the presence of primary substrate.After a five-day cultivation with yeast powder at 30℃ and pH 7,the highest degradation(93.47%2.37%)was achieved.The process of BL1 degrading IBU followed first-order reaction kinetics.The BL1 strain was applied to a small biological aerated filter(BAF)device to form a biofilm with activated sludge.IBU removal by the BAF was consistent with the results of static tests.The removal of IBU was 32.01% to 44.04% higher than for a BAF without BL1.The indigenous bacterial community was able to effectively remove CODMn(permanganate index)and ammonia nitrogen in the presence of BL1.展开更多
The LaCo_(0.94)Pt_(0.06)O_(3) catalyst is reduced under 5% H_(2)/Ar at different temperatures to get Pt/LaCoO_(3) with high catalytic activity for soot oxidation.Transmission electron microscopy(TEM),scanning electron...The LaCo_(0.94)Pt_(0.06)O_(3) catalyst is reduced under 5% H_(2)/Ar at different temperatures to get Pt/LaCoO_(3) with high catalytic activity for soot oxidation.Transmission electron microscopy(TEM),scanning electron microscopy(SEM),X-ray diffraction(XRD),Brunauer-Emmett-Teller method(BET),X-ray photoelectron spectroscopy(XPS),H_(2)-temperature programmed reduction(H_(2)-TPR),O_(2)-temperature programmed desorption(O_(2)-TPD) and thermogravimetric analysis(TGA) were used to study the physicochemical properties of the catalyst.SEM and TEM results indicate that Pt nanoparticles(<10 nm) are grown homogeneously on the surface of the LaCoO_(3) matrix after in-situ reduction.XRD shows that the reduced catalyst has a high symmetrical structure.TGA results indicate that all reduced catalysts exhibit an excellent activity,especially the catalyst reduced at 350℃(T_(10)=338℃,T_(50)=393℃,T_(90)=427℃).And perovskite is the primary active component.According to XPS study,the high symmetrical structure benefits the mobility of oxygen vacancy,and Pt nanoparticles induce the oxygen vacancy to move to its adjacent situation,resulting in more adsorbed oxygen on the surface of the reduced catalyst and increasing the activity.The possible reaction principle is also proposed.展开更多
In general,tooth wear is difficult to be noticed until it leads to toothache in vivo.Developing a dynamic dental wear monitoring system to predict tooth wear in daily life is a necessity.The translation between comple...In general,tooth wear is difficult to be noticed until it leads to toothache in vivo.Developing a dynamic dental wear monitoring system to predict tooth wear in daily life is a necessity.The translation between complex surface wear morphology and corresponding digital signal source is a technical limitation to develop this kind of monitoring system.Microwear texture analysis has been widely employed in predicting diet by a palaeontologist.The main question is whether the microwear texture analysis has potential development space to develop a sensor for monitoring tooth wear.According to obtained results,the microwear texture analysis had enough sensitivity to display the surface morphology variations for different chewing foods and various angles.The corresponding sensitive digital signal of tooth microwear surface morphology makes it possible to develop a dental microwear sensor.展开更多
基金Supported by Heilongjiang Provincial Health and Family Planning Commission Research Project,No.2017-413
文摘BACKGROUND Oral cancer(OC)is the most common malignant tumor in the oral cavity,and is mainly seen in middle-aged and elderly men.At present,OC is mainly treated clinically by surgery or combined with radiotherapy and chemotherapy;but recently,more and more studies have shown that the stress trauma caused by surgery and the side effects of radiotherapy and chemotherapy seriously affect the prognosis of patients.AIM To determine the significance of 125I radioactive seed implantation on growth differentiation factor 11(GDF11)and programmed death receptor-1(PD-1)during treatment of OC.METHODS A total of 184 OC patients admitted to The Second Affiliated Hospital of Jiamusi University from May 2015 to May 2017 were selected as the research subjects for prospective analysis.Of these patients,89 who received 125I radioactive seed implantation therapy were regarded as the research group(RG)and 95 patients who received surgical treatment were regarded as the control group(CG).The clinical efficacy,incidence of adverse reactions and changes in GDF11 and PD-1 before treatment(T0),2 wk after treatment(T1),4 wk after treatment(T2)and 6 wk after treatment(T3)were compared between the two groups.RESULTS The efficacy and recurrence rate in the RG were better than those in the CG(P<0.05),while the incidence of adverse reactions and survival rate were not different.There was no difference in GDF11 and PD-1 between the two groups at T0 and T1,but these factors were lower in the RG than in the CG at T2 and T3(P<0.05).Using receiver operating characteristic(ROC)curve analysis,GDF11 and PD-1 had good predictive value for efficacy and recurrence(P<0.001).CONCLUSION 125I radioactive seed implantation has clinical efficacy and can reduce the recurrence rate in patients with OC.This therapy has marked potential in clinical application.The detection of GDF11 and PD-1 in patients during treatment showed good predictive value for treatment efficacy and recurrence in OC patients,and may be potential targets for future OC treatment.
文摘Chlorinated organic residual liquid is produced from the distillation process of new refrigerants production. It is difficult to be treated by traditional water treatment process and incineration process. In this study, a carbonization process at atmospheric pressure was used to convert this residual liquid to carbonaceous product and organic gas in 2 h at 230℃ or 260℃. The carbonaceous product was characterized by scanning electron microscope, Fourier-transform infrared spectrometer and thermo gravimetric analysis. The element composition and the high heat value of these products were similar to anthracite and lignite, respectively, showing that they could be used as alternative fuels. The components of organic gas were analyzed using gas chromatography-mass spectrometry and the gas had potential for incineration.
文摘Nonylphenol polyethoxylates (NPEOs) are widely used as nonionic surfactants in many industry fields. High concentration NPEOs waste water is produced in some production processes. It is often treated to realize reduction by distillation. Therefore, NPEOs waste liquid with higher concentration is produced and it is difficult to be treated by traditional water treatment process. In this study, hydrothermal carbonization process was used to convert NPEOs waste liquid to carbonaceous product (hydrochar) with sulfuric acid as additive in 24 h at 200°C. The hydrochar was characterized by scanning electron microscope, Fourier-transform infrared spectrometer and thermogravimetric analysis. The element composition and the high heat value of the hydrochar were similar to lignite, showing that it could be used as an alternative fuel.
基金supported by the National Natural Science Foundation of China(42221003,4202530442103084)the Research Projects from the Chinese Academy of Sciences(XDB40000000)+1 种基金the Science and Technology Innovation Project of Laoshan Laboratory(LSKJ202203300)the CAS Youth Interdisciplinary Team。
文摘A"once-in-a-millennium"super rainstorm battered Zhengzhou,central China,from 07/17/2021 to 07/22/2021(named"7.20"Zhengzhou rainstorm).It killed 398 people and caused billions of dollars in damage.A pressing question is whether rainstorms of this intensity can be effectively documented by geological archives to understand better their historical variabilities beyond the range of meteorological data.Here,four land snail shells were collected from Zhengzhou,and weekly to daily resolved snail shellδ^(18)O records from June to September of 2021 were obtained by gas-source mass spectrometry and secondary ion mass spectrometry.The daily resolved records show a dramatic negative shift between 06/18/2021 and 09/18/2021,which has been attributed to the"7.20"Zhengzhou rainstorm.Moreover,the measured amplitude of this shift is consistent with the theoretical value estimated from the flux balance model and instrumental data for the"7.20"Zhengzhou rainstorm.Our results suggest that the ultra-high resolutionδ^(18)O of land snail shells have the potential to reconstruct local synoptic scale rainstorms quantitatively,and thus fossil snail shells in sedimentary strata can be valuable material for investigating the historical variability of local rainstorms under different climate backgrounds.
基金funding support from the National Natural Science Foundation of China(No.81872749)Shenzhen Science and Technology Innovation Commission(Nos.20200815000631001 and JCYJ20200109120414564)Peking University。
文摘Adenine is an essential building block of genetic material and a range of coenzymes.Chemical probes containing an adenine moiety have been used in kinase profiling studies in cell lysates.Here we report that adenine-derived small-molecule probes with an activated ester reactive group can covalently modify a conserved lysine residue of protein kinases and capture a number of nucleotide-binding proteins within living cells.
基金supported by the National Key Research and Development Program of China (Grant No. 2017YFA0603401)Shaanxi Science Fund for Distinguished Young Scholars (Grant No. 2018JC-023)+2 种基金Youth Innovation Promotion Association (Grant No. 2012295)West Light Foundation of Chinese Academy of Sciencesa part of The "Belt & Road" Project of the Institute of Earth Environment, Chinese Academy of Sciences
文摘Application of X-ray fluorescence core-scanning(XRF-CS) on both marine and lake sediments has achieved remarkable results. However, its application has not been widely extended to the research on speleothems. In this study, we measure the Sr abundance and the Sr/Ca ratios of three stalagmites(two aragonite stalagmites, one calcite stalagmite) using the state-of-the-art fourth-generation Avaatech high-resolution XRF core scanner. Through comparisons among different scan paths and among different scan resolutions, as well as comparisons with inductively coupled plasma optical emission spectrometer(ICP-OES), Itrax XRF, and Artax XRF results, we confirm that the Avaatech XRF core scanner could precisely, quickly, and nondestructively analyze the high-resolution Sr abundance of speleothems. Furthermore, we combine the stalagmite δ^(18)O records to explore the paleoclimatic significance of the measured stalagmite Sr/Ca.
基金funded by the National Natural Science Foundation of China(Grant Nos.21767013 and 51741805)the Natural Science Foundation of Jiangxi Province(No.20151BA B213018).
文摘Ibuprofen(IBU)is widely used in the world as anti-inflammatory drug,which posed health risk to the environment.A bacterium capable of degrading IBU was isolated from activated sludge in a sewage treatment plant.According to its morphological,physiologic,and biochemical characteristics,as well as 16S rRNA sequence analysis,the strain was identified as Serratia marcescens BL1(BL1).Degradation of IBU required the presence of primary substrate.After a five-day cultivation with yeast powder at 30℃ and pH 7,the highest degradation(93.47%2.37%)was achieved.The process of BL1 degrading IBU followed first-order reaction kinetics.The BL1 strain was applied to a small biological aerated filter(BAF)device to form a biofilm with activated sludge.IBU removal by the BAF was consistent with the results of static tests.The removal of IBU was 32.01% to 44.04% higher than for a BAF without BL1.The indigenous bacterial community was able to effectively remove CODMn(permanganate index)and ammonia nitrogen in the presence of BL1.
基金Project supported by the Joint Funds of the National Natural Science Foundation of China(U20A20132)。
文摘The LaCo_(0.94)Pt_(0.06)O_(3) catalyst is reduced under 5% H_(2)/Ar at different temperatures to get Pt/LaCoO_(3) with high catalytic activity for soot oxidation.Transmission electron microscopy(TEM),scanning electron microscopy(SEM),X-ray diffraction(XRD),Brunauer-Emmett-Teller method(BET),X-ray photoelectron spectroscopy(XPS),H_(2)-temperature programmed reduction(H_(2)-TPR),O_(2)-temperature programmed desorption(O_(2)-TPD) and thermogravimetric analysis(TGA) were used to study the physicochemical properties of the catalyst.SEM and TEM results indicate that Pt nanoparticles(<10 nm) are grown homogeneously on the surface of the LaCoO_(3) matrix after in-situ reduction.XRD shows that the reduced catalyst has a high symmetrical structure.TGA results indicate that all reduced catalysts exhibit an excellent activity,especially the catalyst reduced at 350℃(T_(10)=338℃,T_(50)=393℃,T_(90)=427℃).And perovskite is the primary active component.According to XPS study,the high symmetrical structure benefits the mobility of oxygen vacancy,and Pt nanoparticles induce the oxygen vacancy to move to its adjacent situation,resulting in more adsorbed oxygen on the surface of the reduced catalyst and increasing the activity.The possible reaction principle is also proposed.
基金Natural Science Foundation of Zhejiang Province,Grant/Award Number:LQ19E050006The Technology Innovation 2025 Program of the Municipality of Ningbo,Grant/Award Number:2019B10122+5 种基金State Key Laboratory of TribologyNingbo UniversityNingbo Natural Science Foundation,Grant/Award Number:202003N4091Ministry of Education of Key Laboratory of Impact and Safety Engineering,Grant/Award Number:CJ202012Municipality of Ningbo,Zhejiang Province,China,Grant/Award Number:2019B10122Natural Science Foundation of Zhejiang Education Department,Grant/Award Number:Y201839291。
文摘In general,tooth wear is difficult to be noticed until it leads to toothache in vivo.Developing a dynamic dental wear monitoring system to predict tooth wear in daily life is a necessity.The translation between complex surface wear morphology and corresponding digital signal source is a technical limitation to develop this kind of monitoring system.Microwear texture analysis has been widely employed in predicting diet by a palaeontologist.The main question is whether the microwear texture analysis has potential development space to develop a sensor for monitoring tooth wear.According to obtained results,the microwear texture analysis had enough sensitivity to display the surface morphology variations for different chewing foods and various angles.The corresponding sensitive digital signal of tooth microwear surface morphology makes it possible to develop a dental microwear sensor.
