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A Green Approach to Producing Polymer Microparticles for Local Sustained Release of Flavopiridol
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作者 Matthew J.OWEN Jasper H.N.YIK +3 位作者 Congwang YE Brianca NETTO Dominik R.HAUDENSCHILD gang-yu liu 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2021年第5期1116-1124,共9页
Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug delivery.Current synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organ... Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug delivery.Current synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organic phase solvent.Due to the health and environmental toxicity of DCM and its slow degradation,this work replaces DCM with a greener solvent,dimethyl carbonate(DMC). 展开更多
关键词 RELEASE replace EMULSION
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Controlled Molecular Assembly of Tetrazine Derivatives on Surfaces
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作者 Shuo Wang Shuang liu +3 位作者 Audrey Sulkanen Joseph M.Fox Xinqiao Jia gang-yu liu 《CCS Chemistry》 CAS 2022年第1期162-172,共11页
While self-assembly is relatively well-known and widely used to form hierarchical structures and thin film coatings,controlled assembly is less known and utilized.Our prior work has demonstrated the concept of control... While self-assembly is relatively well-known and widely used to form hierarchical structures and thin film coatings,controlled assembly is less known and utilized.Our prior work has demonstrated the concept of controlled assembly of macromolecules such as star polymers[molecular weight(M_(w))∼383 kDa,hydrodynamic radius R∼13.8 nm]in droplets.This work extends this concept to smaller molecules,in this case,poly(ethylene glycol)bis-tetrazine(PEGbisTz,M_(w) 8.1 kDa,R∼1.5 nm).The key to controlled molecular assembly is to first deliver ultrasmall volumes(sub-fL)of solution containing PEG-bisTz to a substrate.The solvent evaporates rapidly due to the minute volume,thus forcing the assembly of solute,whose overall size and dimension are dictated by the initial liquid geometry and size.Using prepatterned surfaces,this work revealed that the initial liquid shape can be further tuned,and we could control the final assembly of solute such as PEGbisTz molecules.The degree of control was demonstrated by varying the micropatterns and delivery conditions.This work demonstrated the validity of controlled assembly for PEG-bisTz and enables three-dimensional(3D)nanoprinting of functional materials.The technology has promising applications in nanophotonics,nanoelectronics,nanocomposite materials,and tissue engineering. 展开更多
关键词 TETRAZINE controlled assembly 3D nanoprinting atomic force microscopy microfluidic trans-cyclooctene
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