Even though the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is related to SARS-CoV and Middle East respiratory syndrome coronavirus(MERS-CoV),identifying effective and safe therapeutic strategies remain...Even though the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is related to SARS-CoV and Middle East respiratory syndrome coronavirus(MERS-CoV),identifying effective and safe therapeutic strategies remains challenging.In search of finding effective treatments to eradicate the virus and improve disease symptoms,scientists are exploring possible therapies such as anti-viral,anti-malaria,immune therapy,and hormone treatments.However,the efficacy of these treatments was not validated on either SARS-CoV or MERS-CoV.In this study,we have reviewed synthetic evidence achieved through systematic and meta-analysis of therapeutics specific for SARS-CoV-2 and observed that the use of the above-mentioned therapies had no clinical benefits in coronavirus disease 2019 patients and,conversely,displayed side effects.展开更多
The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-...The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-coding RNAs have been reported to mediate pathophysiological developments such as metastasis as well as immune suppression within the TME.Given the complex biology of BC,novel personalized therapeutic strategies that address its diverse pathophysiologies are needed to improve clinical outcomes.In this review,we describe the advances in the biology of breast neoplasia,including cellular and molecular biology,heterogeneity,and TME.We review the role of novel molecules such as long non-coding RNAs in the pathophysiology of BC.Finally,we provide an up-to-date overview of anticancer compounds extracted from marine microorganisms,crustaceans,and fishes and their synergistic effects in combination with other anticancer drugs.Marine compounds are a new discipline of research in BC and offer a wide range of anti-cancer effects that could be harnessed to target the various pathways involved in BC development,thus assisting current therapeutic regimens.展开更多
文摘Even though the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is related to SARS-CoV and Middle East respiratory syndrome coronavirus(MERS-CoV),identifying effective and safe therapeutic strategies remains challenging.In search of finding effective treatments to eradicate the virus and improve disease symptoms,scientists are exploring possible therapies such as anti-viral,anti-malaria,immune therapy,and hormone treatments.However,the efficacy of these treatments was not validated on either SARS-CoV or MERS-CoV.In this study,we have reviewed synthetic evidence achieved through systematic and meta-analysis of therapeutics specific for SARS-CoV-2 and observed that the use of the above-mentioned therapies had no clinical benefits in coronavirus disease 2019 patients and,conversely,displayed side effects.
文摘The pathology and physiology of breast cancer(BC),including metastasis,and drug resistance,is driven by multiple signaling pathways in the tumor microenvironment(TME),which hamper antitumor immunity.Recently,long non-coding RNAs have been reported to mediate pathophysiological developments such as metastasis as well as immune suppression within the TME.Given the complex biology of BC,novel personalized therapeutic strategies that address its diverse pathophysiologies are needed to improve clinical outcomes.In this review,we describe the advances in the biology of breast neoplasia,including cellular and molecular biology,heterogeneity,and TME.We review the role of novel molecules such as long non-coding RNAs in the pathophysiology of BC.Finally,we provide an up-to-date overview of anticancer compounds extracted from marine microorganisms,crustaceans,and fishes and their synergistic effects in combination with other anticancer drugs.Marine compounds are a new discipline of research in BC and offer a wide range of anti-cancer effects that could be harnessed to target the various pathways involved in BC development,thus assisting current therapeutic regimens.
