目的:探究刺激性甲状腺球蛋白(ps-TG)水平与中高危分化型甲状腺癌(DTC)患者131碘治疗临床转归的关系。方法:回顾性分析行甲状腺全切手术456例DTC患者临床资料,随访中高危患者临床转归。根据治疗反应评估体系将其分为反应满意组(ER)、可...目的:探究刺激性甲状腺球蛋白(ps-TG)水平与中高危分化型甲状腺癌(DTC)患者131碘治疗临床转归的关系。方法:回顾性分析行甲状腺全切手术456例DTC患者临床资料,随访中高危患者临床转归。根据治疗反应评估体系将其分为反应满意组(ER)、可接受(AR)组和欠佳(IR)组。分析各组患者的临床特征及131碘治疗前ps-TG水平,评价ps-TG水平对131碘治疗反应的临床预测价值。结果:ER、AR及IR三组患者性别、甲状腺外侵犯、颈部淋巴结转移及治疗前ps-TG水平存在统计学差异(P<0.001);IR组的131碘治疗前ps-Tg水平明显高于非IR组(P<0.001),ER组与AR组问差异无统计学意义(P=0.326)。诊断IR的ps-Tg界值点为28.3 ng/m L (敏感度57.5%,特异度87.1%),ROC曲线下面积(AUC=0.774,95%CI:0.701~0.847)。结论:ps-TG水平对中高危DTC患者131碘治疗后临床转归具有一定预测价值。展开更多
Background: To explore the hepatoprotective effect of Yigan mingmu oral liquid (YGMM) on isoniazid-rifampicin induced liver injury in rats. Methods: Total 38 SD rats were randomly divided into 6 groups including contr...Background: To explore the hepatoprotective effect of Yigan mingmu oral liquid (YGMM) on isoniazid-rifampicin induced liver injury in rats. Methods: Total 38 SD rats were randomly divided into 6 groups including control group, model group, silymarin positive control group, and three YGMM treatment groups. Model group was administered intragastrically with INH (100 mg/kg) and RIF (100 mg/kg) for 14 days. Silymarin group and YGMM treatment groups were administered intragastrically with silymarin (100 mg/kg) and different doses of YGMM (1, 2.5, 5 mg/kg) 2 hours before INH and RIF administration from day 4 to day 14.?Results: Rats were sacrificed 16 hours after the last day treatment to determine the activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), as well as total bilirubin (TB) content. Oxidative stress was evaluated by measuring total superoxide dismutase (T-SOD) and malondialdehyde (MDA) levels. Histopathological changes in liver tissues were observed under an optical microscope by using hematoxylin and eosin staining. The mice?in model groups showed significantly (p < 0.05) increased levels in AST, ALT, ALP, TB and MDA compared to their control groups;and showed significantly (p < 0.05) decreased level in T-SOD. These changes were significantly (p < 0.05) reversed by the YGMM treatments in a dose-dependent manner. Hepatic pathological changes were attenuated or even reversed by silymarin or YGMM treatments. Conclusions: YGMM has a good hepatoprotective activity on isoniazid-rifampicin induced liver injuries in rats.展开更多
Objective With the improvement of people＇s living standards, people＇s requests for beauty are increasing. Skin whitening and lightening have become the pursuit of many women, and whitening and removing freckles have...Objective With the improvement of people＇s living standards, people＇s requests for beauty are increasing. Skin whitening and lightening have become the pursuit of many women, and whitening and removing freckles have become the focus of scientific research. At present, widely used whitening agents, such as kojic acid, vitamin C, and its derivatives, have shortcomings such as poor stability and retarded effect. Therefore, safer and more effective whitening products from herbs are urgently needed. To explore the possibility of triterpenes as whitening active substance, the effects of total triterpenes of Poria（TTP） and poricoic acid A（PAA） on mushroom tyrosinase activities and B16 cells were investigated, and their mechanisms on mushroom tyrosinase were also studied. Methods Using arbutin and nicotinamide as reference substances, we determinated the inhibitory effects of TTP and PAA on mushroom tyrosinase and tyrosinase in B16 cells and then studied the inhibitory mechanism on mushroom tyrosinase. Results TTP and PAA exhibited good inhibitory effects on the activities of monophenolase and diphenolase in mushroom tyrosinase, as well as a certain inhibitory effect on tyrosinase in B16 cells. Conclusion TTP and PAA are potential whitening active ingredients.展开更多
文摘目的:探究刺激性甲状腺球蛋白(ps-TG)水平与中高危分化型甲状腺癌(DTC)患者131碘治疗临床转归的关系。方法:回顾性分析行甲状腺全切手术456例DTC患者临床资料,随访中高危患者临床转归。根据治疗反应评估体系将其分为反应满意组(ER)、可接受(AR)组和欠佳(IR)组。分析各组患者的临床特征及131碘治疗前ps-TG水平,评价ps-TG水平对131碘治疗反应的临床预测价值。结果:ER、AR及IR三组患者性别、甲状腺外侵犯、颈部淋巴结转移及治疗前ps-TG水平存在统计学差异(P<0.001);IR组的131碘治疗前ps-Tg水平明显高于非IR组(P<0.001),ER组与AR组问差异无统计学意义(P=0.326)。诊断IR的ps-Tg界值点为28.3 ng/m L (敏感度57.5%,特异度87.1%),ROC曲线下面积(AUC=0.774,95%CI:0.701~0.847)。结论:ps-TG水平对中高危DTC患者131碘治疗后临床转归具有一定预测价值。
文摘Background: To explore the hepatoprotective effect of Yigan mingmu oral liquid (YGMM) on isoniazid-rifampicin induced liver injury in rats. Methods: Total 38 SD rats were randomly divided into 6 groups including control group, model group, silymarin positive control group, and three YGMM treatment groups. Model group was administered intragastrically with INH (100 mg/kg) and RIF (100 mg/kg) for 14 days. Silymarin group and YGMM treatment groups were administered intragastrically with silymarin (100 mg/kg) and different doses of YGMM (1, 2.5, 5 mg/kg) 2 hours before INH and RIF administration from day 4 to day 14.?Results: Rats were sacrificed 16 hours after the last day treatment to determine the activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), as well as total bilirubin (TB) content. Oxidative stress was evaluated by measuring total superoxide dismutase (T-SOD) and malondialdehyde (MDA) levels. Histopathological changes in liver tissues were observed under an optical microscope by using hematoxylin and eosin staining. The mice?in model groups showed significantly (p < 0.05) increased levels in AST, ALT, ALP, TB and MDA compared to their control groups;and showed significantly (p < 0.05) decreased level in T-SOD. These changes were significantly (p < 0.05) reversed by the YGMM treatments in a dose-dependent manner. Hepatic pathological changes were attenuated or even reversed by silymarin or YGMM treatments. Conclusions: YGMM has a good hepatoprotective activity on isoniazid-rifampicin induced liver injuries in rats.
基金Project of National Twelve-Five Year Research Program of China(2011BAI06B03-2 and 2012BAI29B03)
文摘Objective With the improvement of people＇s living standards, people＇s requests for beauty are increasing. Skin whitening and lightening have become the pursuit of many women, and whitening and removing freckles have become the focus of scientific research. At present, widely used whitening agents, such as kojic acid, vitamin C, and its derivatives, have shortcomings such as poor stability and retarded effect. Therefore, safer and more effective whitening products from herbs are urgently needed. To explore the possibility of triterpenes as whitening active substance, the effects of total triterpenes of Poria（TTP） and poricoic acid A（PAA） on mushroom tyrosinase activities and B16 cells were investigated, and their mechanisms on mushroom tyrosinase were also studied. Methods Using arbutin and nicotinamide as reference substances, we determinated the inhibitory effects of TTP and PAA on mushroom tyrosinase and tyrosinase in B16 cells and then studied the inhibitory mechanism on mushroom tyrosinase. Results TTP and PAA exhibited good inhibitory effects on the activities of monophenolase and diphenolase in mushroom tyrosinase, as well as a certain inhibitory effect on tyrosinase in B16 cells. Conclusion TTP and PAA are potential whitening active ingredients.
