The incidence of hyperbilirubinemia is high clinically, which is difficult to cure by medication, surgery or interventional therapies. Non-bioartificial liver is the main alternative in the blood purification for hype...The incidence of hyperbilirubinemia is high clinically, which is difficult to cure by medication, surgery or interventional therapies. Non-bioartificial liver is the main alternative in the blood purification for hyperbilirubinemia, which includes plasma exchange, hemoperfusion, hemodialysis, molecular adsorbent recycling system and so on. The research results and clinical experiences in China show that these methods are effective in lowering high levels of bilirubin with fewer side effects. The hyperbilirubinemias of different causes, with different complications or accompanying different diseases can be treated by different methods. Bioartificial liver, hybrid artificial liver support system and adsorbent membrane material have also been studied and their development in reducing hyperbilirubinemias has been achieved. This article gives a brief overview on the actuality and research improvement in blood purification for hyperbilirubinemia in China.展开更多
The stability of anion exchange membranes（AEMs） is an important feature of alkaline exchange membrane fuel cells（AEMFCs）, which has been extensively studied. However it remains a real challenge due to the harsh wo...The stability of anion exchange membranes（AEMs） is an important feature of alkaline exchange membrane fuel cells（AEMFCs）, which has been extensively studied. However it remains a real challenge due to the harsh working condition. Herein, we developed a novel type of polysulfone-based AEMs with three modified 1,2-dimethylbenzimidazoliums containing different substitutes at C4-and C7-position. The results showed that the introduction of the substitutes could obviously improve the dimensional and alkaline stabilities of the corresponding membranes. The swelling ratios of resultant AEMs were all lower than 10% after water immersion. The membrane with 4,7-dimethoxy-1,2-dimethylbenzimidazolium group exhibited the highest alkaline stability. Only 9.2% loss of hydroxide conductivity was observed after treating the membrane in 1 mol·L^（-1） KOH solution at 80 °C for 336 h. Furthermore, the density functional theory（DFT） study on the three functional group models showed that the substitutes at C4-and C7-position affected the lowest unoccupied molecular orbital（LUMO） energies of the different 1,2-dimethylbenzimidazolium groups.展开更多
文摘The incidence of hyperbilirubinemia is high clinically, which is difficult to cure by medication, surgery or interventional therapies. Non-bioartificial liver is the main alternative in the blood purification for hyperbilirubinemia, which includes plasma exchange, hemoperfusion, hemodialysis, molecular adsorbent recycling system and so on. The research results and clinical experiences in China show that these methods are effective in lowering high levels of bilirubin with fewer side effects. The hyperbilirubinemias of different causes, with different complications or accompanying different diseases can be treated by different methods. Bioartificial liver, hybrid artificial liver support system and adsorbent membrane material have also been studied and their development in reducing hyperbilirubinemias has been achieved. This article gives a brief overview on the actuality and research improvement in blood purification for hyperbilirubinemia in China.
基金financially supported by the National Natural Science Foundation of China (No. 21404018)Fundamental Research Funds for the Central Universities (No. DUT16RC(4)79)+2 种基金Education Department of the Liaoning Province (No. LT2015007)Fundamental Research Funds for the Central Universities (No. DUT16TD19)Chang Jiang Scholar Program (No. T2012049)
文摘The stability of anion exchange membranes（AEMs） is an important feature of alkaline exchange membrane fuel cells（AEMFCs）, which has been extensively studied. However it remains a real challenge due to the harsh working condition. Herein, we developed a novel type of polysulfone-based AEMs with three modified 1,2-dimethylbenzimidazoliums containing different substitutes at C4-and C7-position. The results showed that the introduction of the substitutes could obviously improve the dimensional and alkaline stabilities of the corresponding membranes. The swelling ratios of resultant AEMs were all lower than 10% after water immersion. The membrane with 4,7-dimethoxy-1,2-dimethylbenzimidazolium group exhibited the highest alkaline stability. Only 9.2% loss of hydroxide conductivity was observed after treating the membrane in 1 mol·L^（-1） KOH solution at 80 °C for 336 h. Furthermore, the density functional theory（DFT） study on the three functional group models showed that the substitutes at C4-and C7-position affected the lowest unoccupied molecular orbital（LUMO） energies of the different 1,2-dimethylbenzimidazolium groups.
