The pyrrole moiety is an important structural motif in functional materials,natural products,and pharmaceuticals.More and more synthetic strategies toward pyrroles have emerged,where various efficient building blocks ...The pyrrole moiety is an important structural motif in functional materials,natural products,and pharmaceuticals.More and more synthetic strategies toward pyrroles have emerged,where various efficient building blocks are developed and these synthons enable the syntheses of pyrroles with different numbers of components.However,no review specifically summarizes the syntheses of pyrroles according to the type and number of employed building blocks.To aid researchers to design appropriate substrates for pyrrole synthesis,herein we summarized the advances in pyrrole syntheses and classified these reactions into four categories according to the number of employed components,which may shed light on developing more efficient synthetic methods toward substituted pyrroles.展开更多
A new method of Lawesson’s reagent-promoted deoxygenation of γ-hydroxypyrrolidones or succinimides was developed for synthesizing substituted pyrroles with 92 examples displayed. This reaction features simple operat...A new method of Lawesson’s reagent-promoted deoxygenation of γ-hydroxypyrrolidones or succinimides was developed for synthesizing substituted pyrroles with 92 examples displayed. This reaction features simple operation, satisfactory yields, wide substrate scope, and excellent functional group tolerance.This robust protocol has been successfully applied in the expeditious syntheses of the key intermediate ofStemona alkaloids.展开更多
Six Stemona alkaloids were synthesized racemically using stemoamide,obtained via a cascade cyclization or our reported transannular cyclization of parvistemoamide,as the common intermediate.Thioamides facilitated the ...Six Stemona alkaloids were synthesized racemically using stemoamide,obtained via a cascade cyclization or our reported transannular cyclization of parvistemoamide,as the common intermediate.Thioamides facilitated the separation of isosaxorumamide and saxorumamide,and promoted the first syntheses of other four N-oxide or pyrrolidine bearing Stemona alkaloids via chemoselective reduction and oxidation.展开更多
基金We thank the financial support from the Recruitment Program of Global Experts(1000 Talents Plan)Gansu Province Science Foundation for Distinguished Young Scholars(No.20JR5RA304).
文摘The pyrrole moiety is an important structural motif in functional materials,natural products,and pharmaceuticals.More and more synthetic strategies toward pyrroles have emerged,where various efficient building blocks are developed and these synthons enable the syntheses of pyrroles with different numbers of components.However,no review specifically summarizes the syntheses of pyrroles according to the type and number of employed building blocks.To aid researchers to design appropriate substrates for pyrrole synthesis,herein we summarized the advances in pyrrole syntheses and classified these reactions into four categories according to the number of employed components,which may shed light on developing more efficient synthetic methods toward substituted pyrroles.
文摘A new method of Lawesson’s reagent-promoted deoxygenation of γ-hydroxypyrrolidones or succinimides was developed for synthesizing substituted pyrroles with 92 examples displayed. This reaction features simple operation, satisfactory yields, wide substrate scope, and excellent functional group tolerance.This robust protocol has been successfully applied in the expeditious syntheses of the key intermediate ofStemona alkaloids.
基金Z.W.and H.W.were responsible for conceiving the synthetic route,helping to resolve problems,providing financial support,and revising the paper.T.S.and F.C.as the main conductors with equal contribution were responsible for synthesizing compounds,analyzing experimental results,and collecting data.J.C.,X.W.and G.Y.have assisted T.S.and F.C.in synthesizing compounds.T.S.wrote this manuscript.
文摘Six Stemona alkaloids were synthesized racemically using stemoamide,obtained via a cascade cyclization or our reported transannular cyclization of parvistemoamide,as the common intermediate.Thioamides facilitated the separation of isosaxorumamide and saxorumamide,and promoted the first syntheses of other four N-oxide or pyrrolidine bearing Stemona alkaloids via chemoselective reduction and oxidation.
