Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy

Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide bonds.The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells.Based on in-vitro results,a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of ROS.After an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations.Overall,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.

Hydrophobic,Hemostatic and Durable Nanofiber Composites with a Screw‑Like Surface Architecture for Multifunctional Sensing Electronics

MXene-decorated textile composites have attracted tremendous attention,due to their possible applications in wearable sensing electronics.However,the easy oxidation,low strain sensitivity and poor water-proof performance restrict the applications of MXene-based smart textiles.Here,we developed a flexible and hydrophobic polymer nanofibrous composite with a screw-like structure by assembling MXene nanosheets onto a prestretched polyurethane(PU)nanofiber surface and subsequent fluorination treatment.The thin hydrophobic fluorosilane layer can greatly prevent the MXene shell from being oxidized and simultaneously endow the nanofiber composite with good hemostatic performance.The wrinkled MXene shell with the screw-like structure enhances the sensitivity of MXene@PU nanofiber composite(HMPU)toward strain,and the hydrophobic strain sensor exhibits a high gauge factor(324.4 in the strain range of 85–100%),and can detect different human movements.In virtue of its excellent water-proof performance,HMPU can function normally in corrosive and underwater conditions.In addition,the resistance of HMPU exhibits a negative temperature coefficient;thus,HMPU shows potential for monitoring temperature and providing a temperature alarm.The multifunctional HMPU shows broad application prospects in smart wearable electronics.