The onset of inflammatory bowel disease(IBD)involves many factors,including environmental parameters,microorganisms,and the immune system.Although research on IBD continues to expand,the specific pathogenesis mechanis...The onset of inflammatory bowel disease(IBD)involves many factors,including environmental parameters,microorganisms,and the immune system.Although research on IBD continues to expand,the specific pathogenesis mechanism is still unclear.Protein modification refers to chemical modification after protein biosynthesis,also known as post-translational modification(PTM),which causes changes in the properties and functions of proteins.Since proteins can be modified in different ways,such as acetylation,methylation,and phosphorylation,the functions of proteins in different modified states will also be different.Transitions between different states of protein or changes in modification sites can regulate protein properties and functions.Such modifications like neddylation,sumoylation,glycosylation,and acetylation can activate or inhibit various signaling pathways(e.g.,nuclear factor-κB(NF-κB),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT))by changing the intestinal flora,regulating immune cells,modulating the release of cytokines such as interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ),and ultimately leading to the maintenance of the stability of the intestinal epithelial barrier.In this review,we focus on the current understanding of PTM and describe its regulatory role in the pathogenesis of IBD.展开更多
基金This work was supported by the Zhenjiang Key Research and Development Plan(Social Development)(No.SH2019025)the Scientific Research Project of Health Commission of Jiangsu Province(No.Z2019036)+1 种基金the Science and Technology Innovation Fund Project of Zhenjiang City(No.SH2021066)the Taicang Science and Technology Planning Project(No.TC2020JCYL17),China.
文摘The onset of inflammatory bowel disease(IBD)involves many factors,including environmental parameters,microorganisms,and the immune system.Although research on IBD continues to expand,the specific pathogenesis mechanism is still unclear.Protein modification refers to chemical modification after protein biosynthesis,also known as post-translational modification(PTM),which causes changes in the properties and functions of proteins.Since proteins can be modified in different ways,such as acetylation,methylation,and phosphorylation,the functions of proteins in different modified states will also be different.Transitions between different states of protein or changes in modification sites can regulate protein properties and functions.Such modifications like neddylation,sumoylation,glycosylation,and acetylation can activate or inhibit various signaling pathways(e.g.,nuclear factor-κB(NF-κB),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT))by changing the intestinal flora,regulating immune cells,modulating the release of cytokines such as interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ),and ultimately leading to the maintenance of the stability of the intestinal epithelial barrier.In this review,we focus on the current understanding of PTM and describe its regulatory role in the pathogenesis of IBD.
