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Small interfering RNA for cancer treatment:overcoming hurdles in delivery 被引量:11
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作者 Nitin Bharat Charbe Nikhil D.Amnerkar +13 位作者 B.Ramesh Murtaza M.Tambuwala Hamid A.Bakshi Alaa A.A.Aljabali Saurabh C.Khadse Rajendran Satheeshkumar Saurabh Satija Meenu Metha Dinesh Kumar Chellappan garima shrivastava Gaurav Gupta Poonam Negi Kamal Dua Flavia C.Zacconin 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2020年第11期2075-2109,共35页
In many ways,cancer cells are different from healthy cells.A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells.Currently,nanotechnology-based delivery system... In many ways,cancer cells are different from healthy cells.A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells.Currently,nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells.This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells.It also provides the necessary information about siRNA development and its mechanism of action.Overall,this review gives us a clear picture of lipid and polymer-based drug delivery systems,which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies. 展开更多
关键词 Small interfering RNA(siRNA) NANOMEDICINE Liposomes Micelles CANCER POLYMER
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