Cloud computing is an Information Technology deployment model established on virtualization.Task scheduling states the set of rules for task allocations to an exact virtual machine in the cloud computing environment.H...Cloud computing is an Information Technology deployment model established on virtualization.Task scheduling states the set of rules for task allocations to an exact virtual machine in the cloud computing environment.However,task scheduling challenges such as optimal task scheduling performance solutions,are addressed in cloud computing.First,the cloud computing performance due to task scheduling is improved by proposing a Dynamic Weighted Round-Robin algorithm.This recommended DWRR algorithm improves the task scheduling performance by considering resource competencies,task priorities,and length.Second,a heuristic algorithm called Hybrid Particle Swarm Parallel Ant Colony Optimization is proposed to solve the task execution delay problem in DWRR based task scheduling.In the end,a fuzzy logic system is designed for HPSPACO that expands task scheduling in the cloud environment.A fuzzy method is proposed for the inertia weight update of the PSO and pheromone trails update of the PACO.Thus,the proposed Fuzzy Hybrid Particle Swarm Parallel Ant Colony Optimization on cloud computing achieves improved task scheduling by minimizing the execution and waiting time,system throughput,and maximizing resource utilization.展开更多
Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presen...Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective "size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines.展开更多
文摘Cloud computing is an Information Technology deployment model established on virtualization.Task scheduling states the set of rules for task allocations to an exact virtual machine in the cloud computing environment.However,task scheduling challenges such as optimal task scheduling performance solutions,are addressed in cloud computing.First,the cloud computing performance due to task scheduling is improved by proposing a Dynamic Weighted Round-Robin algorithm.This recommended DWRR algorithm improves the task scheduling performance by considering resource competencies,task priorities,and length.Second,a heuristic algorithm called Hybrid Particle Swarm Parallel Ant Colony Optimization is proposed to solve the task execution delay problem in DWRR based task scheduling.In the end,a fuzzy logic system is designed for HPSPACO that expands task scheduling in the cloud environment.A fuzzy method is proposed for the inertia weight update of the PSO and pheromone trails update of the PACO.Thus,the proposed Fuzzy Hybrid Particle Swarm Parallel Ant Colony Optimization on cloud computing achieves improved task scheduling by minimizing the execution and waiting time,system throughput,and maximizing resource utilization.
文摘Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective "size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines.
