Developing tools for monitoring the correlations among thousands of financial data streams in an online fashion can be interesting and useful work. We aimed to find highly correlative financial data streams in local p...Developing tools for monitoring the correlations among thousands of financial data streams in an online fashion can be interesting and useful work. We aimed to find highly correlative financial data streams in local patterns. A novel distance metric function slope duration distance (SDD) is proposed, which is compatible with the characteristics of actual financial data streams. Moreover, a model monitoring correlations among local patterns (MCALP) is presented, which dramatically decreases the computational cost using an algorithm quickly online segmenting and pruning (QONSP) with O(1) time cost at each time tick t, and our proposed new grid structure. Experimental results showed that MCALP provides an improvement of several orders of magnitude in performance relative to traditional naive linear scan techniques and maintains high precision. Furthermore, the model is incremental, parallelizable, and has a quick response time.展开更多
As a dendritic cell-specific C-type lectin receptor, DC-SIGN plays an important role in the early stages of many viral infections, including HIV and Ebola, making it an interesting therapeutic target. It has been foun...As a dendritic cell-specific C-type lectin receptor, DC-SIGN plays an important role in the early stages of many viral infections, including HIV and Ebola, making it an interesting therapeutic target. It has been found that DC-SIGN can recognize both highly mannosylated and branched fucosylated oligosaccharides. Herein, we synthesized a new series of homo-and Man-Fuc heteroglycoclusters with diverse structures. The binding properties of these compounds to tetrameric extracellular DC-SIGN were assessed by surface plasmon resonance(SPR). Heteroglycocluster 17 b showed high DC-SIGN-binding activity(K;= 2.6 μM). The structural determinants of this high affinity of 17 b were rationalized by docking and compared with its much less potent isomer 17 a. Therefore, 17 b might serve as a base for the development of potent inhibitors of DC-SIGN-dependent viral infection.展开更多
基金Project (Nos. 2006AA01Z430 and 2007AA01Z309)supported by the National Hi-Tech Research and Development Program (863) of China
文摘Developing tools for monitoring the correlations among thousands of financial data streams in an online fashion can be interesting and useful work. We aimed to find highly correlative financial data streams in local patterns. A novel distance metric function slope duration distance (SDD) is proposed, which is compatible with the characteristics of actual financial data streams. Moreover, a model monitoring correlations among local patterns (MCALP) is presented, which dramatically decreases the computational cost using an algorithm quickly online segmenting and pruning (QONSP) with O(1) time cost at each time tick t, and our proposed new grid structure. Experimental results showed that MCALP provides an improvement of several orders of magnitude in performance relative to traditional naive linear scan techniques and maintains high precision. Furthermore, the model is incremental, parallelizable, and has a quick response time.
基金National Natural Science Foundation of China(NSFC,Grant No.21172015)Wellcome Trust (UK,Grant No.097354/Z/11/Z)+1 种基金ML acknowledges the Research Project RVO61388963 of the Institute of Organic Chemistry and BiochemistryAcademy of Sciences of the Czech Republic,the Czech Science Foundation (Grant No.P20 8/12/G016)。
文摘As a dendritic cell-specific C-type lectin receptor, DC-SIGN plays an important role in the early stages of many viral infections, including HIV and Ebola, making it an interesting therapeutic target. It has been found that DC-SIGN can recognize both highly mannosylated and branched fucosylated oligosaccharides. Herein, we synthesized a new series of homo-and Man-Fuc heteroglycoclusters with diverse structures. The binding properties of these compounds to tetrameric extracellular DC-SIGN were assessed by surface plasmon resonance(SPR). Heteroglycocluster 17 b showed high DC-SIGN-binding activity(K;= 2.6 μM). The structural determinants of this high affinity of 17 b were rationalized by docking and compared with its much less potent isomer 17 a. Therefore, 17 b might serve as a base for the development of potent inhibitors of DC-SIGN-dependent viral infection.
