Objective:The aim of the study was to detect the levels of mannose-binding lectin(MBL),MBL-associated serine protease 2(MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms...Objective:The aim of the study was to detect the levels of mannose-binding lectin(MBL),MBL-associated serine protease 2(MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms.Methods:By using ELISA method,we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma(PTC),30 patients with thyroid adenoma(TA) and 26 healthy people,respectively.Results:Serum MBL level was(565.23 ± 76.70) μg/L in PTCs higher than(324.267 ± 24.74) μg/L in TAs,and(152.69 ± 16.95) μg/L in healthy of controlling group.There was statistical significance between PTC and TA(P < 0.05),however there was no difference between TA and healthy(P > 0.05).Serum MASP-2 level was(726.153 ± 78.88) μg/L in PTCs higher than(379.266 ± 30.26) μg/L in TAs,and(203.846 ± 29.09) μg/L in healthy.Serum MASP-2 level was higher in PTCs than TAs,and the difference had statistical significance(P < 0.01).But no difference was observed between in TAs and healthy.Conclusion:These findings might reflect inflammatory processes induced by defense mechanisms,in response to the development of the tumour.MBL may also be involved in the elimination of possible tumourigenic pathogens.展开更多
基金Supported by a grant of Natural Science Funds Projects of Hebei Province (No. C2008001306)
文摘Objective:The aim of the study was to detect the levels of mannose-binding lectin(MBL),MBL-associated serine protease 2(MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms.Methods:By using ELISA method,we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma(PTC),30 patients with thyroid adenoma(TA) and 26 healthy people,respectively.Results:Serum MBL level was(565.23 ± 76.70) μg/L in PTCs higher than(324.267 ± 24.74) μg/L in TAs,and(152.69 ± 16.95) μg/L in healthy of controlling group.There was statistical significance between PTC and TA(P < 0.05),however there was no difference between TA and healthy(P > 0.05).Serum MASP-2 level was(726.153 ± 78.88) μg/L in PTCs higher than(379.266 ± 30.26) μg/L in TAs,and(203.846 ± 29.09) μg/L in healthy.Serum MASP-2 level was higher in PTCs than TAs,and the difference had statistical significance(P < 0.01).But no difference was observed between in TAs and healthy.Conclusion:These findings might reflect inflammatory processes induced by defense mechanisms,in response to the development of the tumour.MBL may also be involved in the elimination of possible tumourigenic pathogens.
