Dear Editor, We present here a rare case of primary malignant lymphoma of the glans penis that was detected in a 72-year-old man. Additionally, we have reviewed the literature for reports of primary malignant lym pho...Dear Editor, We present here a rare case of primary malignant lymphoma of the glans penis that was detected in a 72-year-old man. Additionally, we have reviewed the literature for reports of primary malignant lym phoma of the penis. This is most likely the forty-ninth case of primary malignant lymphoma of the penis reported in the medical literature. Lymphomas typically originate from the lymph nodes and lymph tissues; however, the tonsils, spleen and bone marrow are also vulner- able sites. Due to the presence of lymph nodes and lymph tissue throughout the human body, primary malignant lymphomas of glans penis occur rarely. The diagnosis of this rare lymphoma may be dif- ficult and delayed without specific symptoms, and treatment modali- ties are controversial because of the limited number of patients. A 72-year-old male patient was referred to our hospital due to a mass on the left side of the glans penis in May 2007. A physical exa- mination identified two masses, one on the left tip and one on the right tip of his penis. The left lump measured approximately 8 mm in diameter, was hard in nature, and was cystic, reddish in colour and covered the surface of the glans penis with ill-defined margins. There was no visible ulceration and no tenderness on palpation. The cystic mass on the right side measured 15 mm; the lesion was firm in nature, did not protrude from the surface and had no palpable tenderness. The liver and spleen were not palpable, and no other sites oflymphadeno- pathy were observed; B symptoms were absent. Anti-inflammatory treatment was administered at another hospital, but it was unsuccess- ful. On 17 May 2007, the two masses were resected with penile pre- servation. The pathological examination showed the presence of a malignant lymphoma originating from B cells （diffuse large B）, as shown in Figure 1. The patient was diagnosed with diffuse large B-cell lymphoma of the glans penis, stage IE, according to the Ann Arbor classification. No obvious distal metastasis was found by chest X-ray or abdominal ultrasonography before the surgery.展开更多
文摘Dear Editor, We present here a rare case of primary malignant lymphoma of the glans penis that was detected in a 72-year-old man. Additionally, we have reviewed the literature for reports of primary malignant lym phoma of the penis. This is most likely the forty-ninth case of primary malignant lymphoma of the penis reported in the medical literature. Lymphomas typically originate from the lymph nodes and lymph tissues; however, the tonsils, spleen and bone marrow are also vulner- able sites. Due to the presence of lymph nodes and lymph tissue throughout the human body, primary malignant lymphomas of glans penis occur rarely. The diagnosis of this rare lymphoma may be dif- ficult and delayed without specific symptoms, and treatment modali- ties are controversial because of the limited number of patients. A 72-year-old male patient was referred to our hospital due to a mass on the left side of the glans penis in May 2007. A physical exa- mination identified two masses, one on the left tip and one on the right tip of his penis. The left lump measured approximately 8 mm in diameter, was hard in nature, and was cystic, reddish in colour and covered the surface of the glans penis with ill-defined margins. There was no visible ulceration and no tenderness on palpation. The cystic mass on the right side measured 15 mm; the lesion was firm in nature, did not protrude from the surface and had no palpable tenderness. The liver and spleen were not palpable, and no other sites oflymphadeno- pathy were observed; B symptoms were absent. Anti-inflammatory treatment was administered at another hospital, but it was unsuccess- ful. On 17 May 2007, the two masses were resected with penile pre- servation. The pathological examination showed the presence of a malignant lymphoma originating from B cells （diffuse large B）, as shown in Figure 1. The patient was diagnosed with diffuse large B-cell lymphoma of the glans penis, stage IE, according to the Ann Arbor classification. No obvious distal metastasis was found by chest X-ray or abdominal ultrasonography before the surgery.
