Guajadials C-F(1-4),four sesquiterpenoid-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava.Their structures and relative configurations were established by extensive sp...Guajadials C-F(1-4),four sesquiterpenoid-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava.Their structures and relative configurations were established by extensive spectroscopic analysis.A possible biosynthetic pathway for 1-4 was also proposed.展开更多
Engleromyces goetzii is a traditional medicinal mushroom that is widely used to treat infection,inflammation and cancer in Tibet,Sichuan and Yunnan provinces of China.Two new trichothecenes,engleromycones A and B(1 an...Engleromyces goetzii is a traditional medicinal mushroom that is widely used to treat infection,inflammation and cancer in Tibet,Sichuan and Yunnan provinces of China.Two new trichothecenes,engleromycones A and B(1 and 2),one new cuparane-type sesquiterpenoid named infuscol F(11),eight known trichothecene analogs,sambucinol(3),3-deoxysambucinol(4),trichothecolone(5),trichodermol(6),8-deoxytrichothecin(7),trichothecin(8),trichothecinol B(9)and trichothecinol A(10),and one known cyclopentanoid sesquiterpene cyclonerodiol(12)were isolated from the cultures of E.goetzii.The new compounds were elucidated through spectroscopic analyses.The anticancer effects of trichothecenes 1–10 were examined in the HL-60,SMMC-7721,A549,MCF-7,and SW-480 human cancer cell lines using an MTT assay.Trichothecinol A(10)significantly inhibited the growth of MCF-7 cells,with an IC50 value of 0.006 lM,which was comparable to the cytotoxic activity of the positive control,paclitaxel,indicating that trichothecinol A(10)represents a potential anticancer agent.展开更多
Nine previously-unreported farnesylphenols,involving eight neogrifolin derivatives(1–8)and one grifolin analogue(9),together with three known compounds,were isolated from the fruiting bodies of the mushroom Albatrell...Nine previously-unreported farnesylphenols,involving eight neogrifolin derivatives(1–8)and one grifolin analogue(9),together with three known compounds,were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus.Their structures were elucidated as(S)-17-hydroxy-18,20-ene-neogrifolin(1),(S)-18,19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10,22-ene-neogrifolin(3),(9S,10R)-6,10-epoxy-9-hydroxyneo grifolin(4),(9S,10R)-6,9-epoxy-10-hydroxyneogrifolin(5),(-)-13,14-dihydroxyneogrifolin(6),albatrelin G(7),albatrelin H(8),and one grifolin analogue,(S)-10-hydroxygrifolin(9),grifolin(10),neogrifolin(11),and albatrellin(12)by extensive spectroscopic analyses and chemical methods.Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60,SMMC-7721,A-549,and MCF-7,in vitro.展开更多
A series of novel 4b-triazole-podophyllotoxin glycosides were synthesized by utilizing the Click reaction.Evaluation of cytotoxicity against a panel of five human cancer cell lines(HL-60,SMMC-7721,A-549,MCF-7,SW480)us...A series of novel 4b-triazole-podophyllotoxin glycosides were synthesized by utilizing the Click reaction.Evaluation of cytotoxicity against a panel of five human cancer cell lines(HL-60,SMMC-7721,A-549,MCF-7,SW480)using MTT assay shows that most of these compounds show weak cytotoxicity.It was observed that compound 16 shows the highest activity with IC50 values ranging from 2.85 to 7.28 lM,which is more potent than the control drugs etoposide and cisplatin against four of five cancer cell lines tested.Compound 16 is characterized with an a-D-galactosyl residue directly linked to the triazole ring and a 40-OH group on the E ring of the podophyllotoxin scaffold.HPLC investigation of representative compound indicates that incorporation of a sugar moiety seems to improve the chemical stability of the podophyllotoxin scaffold.展开更多
基金The authors acknowledge the National Basic Research Program of China(973 Program,2009CB522300)the“West Light”program of Chinese Academy of Sciences,and the National Natural Science Foundation of China(U1132607).
文摘Guajadials C-F(1-4),four sesquiterpenoid-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava.Their structures and relative configurations were established by extensive spectroscopic analysis.A possible biosynthetic pathway for 1-4 was also proposed.
基金the National Natural Sciences Foundation of China(U1132607,21302194)the National Science&Technology Pillar Program of China(2012BAD23B0305 and 2013BAI11B02).
文摘Engleromyces goetzii is a traditional medicinal mushroom that is widely used to treat infection,inflammation and cancer in Tibet,Sichuan and Yunnan provinces of China.Two new trichothecenes,engleromycones A and B(1 and 2),one new cuparane-type sesquiterpenoid named infuscol F(11),eight known trichothecene analogs,sambucinol(3),3-deoxysambucinol(4),trichothecolone(5),trichodermol(6),8-deoxytrichothecin(7),trichothecin(8),trichothecinol B(9)and trichothecinol A(10),and one known cyclopentanoid sesquiterpene cyclonerodiol(12)were isolated from the cultures of E.goetzii.The new compounds were elucidated through spectroscopic analyses.The anticancer effects of trichothecenes 1–10 were examined in the HL-60,SMMC-7721,A549,MCF-7,and SW-480 human cancer cell lines using an MTT assay.Trichothecinol A(10)significantly inhibited the growth of MCF-7 cells,with an IC50 value of 0.006 lM,which was comparable to the cytotoxic activity of the positive control,paclitaxel,indicating that trichothecinol A(10)represents a potential anticancer agent.
基金the National Natural Sciences Foundation of China(U1132607).
文摘Nine previously-unreported farnesylphenols,involving eight neogrifolin derivatives(1–8)and one grifolin analogue(9),together with three known compounds,were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus.Their structures were elucidated as(S)-17-hydroxy-18,20-ene-neogrifolin(1),(S)-18,19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10,22-ene-neogrifolin(3),(9S,10R)-6,10-epoxy-9-hydroxyneo grifolin(4),(9S,10R)-6,9-epoxy-10-hydroxyneogrifolin(5),(-)-13,14-dihydroxyneogrifolin(6),albatrelin G(7),albatrelin H(8),and one grifolin analogue,(S)-10-hydroxygrifolin(9),grifolin(10),neogrifolin(11),and albatrellin(12)by extensive spectroscopic analyses and chemical methods.Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60,SMMC-7721,A-549,and MCF-7,in vitro.
基金the Fund of State Key Laboratory of Phytochemistry and Plant Resource in West China(P2010-KF07).
文摘A series of novel 4b-triazole-podophyllotoxin glycosides were synthesized by utilizing the Click reaction.Evaluation of cytotoxicity against a panel of five human cancer cell lines(HL-60,SMMC-7721,A-549,MCF-7,SW480)using MTT assay shows that most of these compounds show weak cytotoxicity.It was observed that compound 16 shows the highest activity with IC50 values ranging from 2.85 to 7.28 lM,which is more potent than the control drugs etoposide and cisplatin against four of five cancer cell lines tested.Compound 16 is characterized with an a-D-galactosyl residue directly linked to the triazole ring and a 40-OH group on the E ring of the podophyllotoxin scaffold.HPLC investigation of representative compound indicates that incorporation of a sugar moiety seems to improve the chemical stability of the podophyllotoxin scaffold.
