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Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study 被引量:28
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作者 Zhe Shen You-Ming Li +6 位作者 Chao-Hui Yu Yi Shen Lei xu Cheng-Fu xu Jin-Jin Chen Hua Ye gen-yun xu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第14期2255-2261,共7页
AIM:To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of Ch... AIM:To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of China.METHODS:Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done. RESULTS:Daily alcohol intake ≥ 20 g, duration of drinking ≥ 5 years and obesity were closely related to alcohol-related liver injury (P < 0.05). The odds-ratio (OR) (95% CI) was 1.965 (1.122-3.442), 3.412 (1.789-6.507) and 1.887 (1.261-2.824), respectively. The prevalence rate of alcohol-related liver injury in ≥ 20 g daily alcohol intake group and < 20 g daily alcohol intake group was 37.14% and 12.06%, respectively. The prevalence rate of alcohol-related liver injury in ≥ 5 years drinking group and < 5 years drinking group was 34.44% and 8.53%, respectively. No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking group.CONCLUSION:The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned. 展开更多
关键词 ALCOHOL Liver injury PREVALENCE Case-control study EPIDEMIOLOGY
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Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice 被引量:8
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作者 Guo-Qiang xu Cheng-Fu xu +4 位作者 Hong-Tan Chen Shan Liu Xiao-Dong Teng gen-yun xu Chao-Hui Yu 《World Journal of Gastroenterology》 SCIE CAS 2014年第28期9513-9518,共6页
AIM: To investigate the role of caveolin-3 (CAV3) and cholecystokinin A receptor (CCKAR) in cholesterol gallstone disease (CGD).
关键词 Cholesterol gallstone disease Caveolin-3 Cholecystokinin A receptor Lithogenic diet MECHANISM
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Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study 被引量:4
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作者 Ping xu Cheng-fu xu +5 位作者 Xing-yong Wan Chao-hui yu Chao Shen Peng Chen gen-yun xu You-ming Li 《World Journal of Gastroenterology》 SCIE CAS 2014年第33期11865-11870,共6页
AIM: To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population.
关键词 Fatty liver ALPHA-FETOPROTEIN ASSOCIATION OBESITY Risk factor
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Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults 被引量:1
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作者 Wei-xing CHEN Chuan-qin xu +2 位作者 Shao-hua CHEN gen-yun xu Huai-zhuang YE 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2012年第5期395-401,共7页
Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a sig... Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with al- cohol were significantly higher compared to those after placebo treatment (P<0.05). There were no significant dif- ferences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It may also affect some blood biochemical indicators, but the specific mechanisms need further research. 展开更多
关键词 ETHANOL Citric acid Event-related potential (ERP) P300 Cognitive function ACETALDEHYDE
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