Female germline stem cells(FGSCs)and spermatogonial stem cells(SSCs)are germline stem cells that transmit the genetic material from generation to generation.Hence,it is essential to understand the similarities and dif...Female germline stem cells(FGSCs)and spermatogonial stem cells(SSCs)are germline stem cells that transmit the genetic material from generation to generation.Hence,it is essential to understand the similarities and differences between FGSCs and SSCs.In this study,we comprehensively compared the epigenetics of FGSCs and SSCs,including high-order chromatin organization,chromatin histone modification,and transcriptome by analyzing multiple-omics data(Hi-C,ChIP-seq,and RNA-seq).展开更多
基金supported by National Nature Science Foundation of China(No.81720108017,31871329)the National Major Scientific Instruments and Equipment Development Project,National Nature Science Foundation of China(No.61827814)the China Postdoctoral Science Foundation(No.2021M692081).
文摘Female germline stem cells(FGSCs)and spermatogonial stem cells(SSCs)are germline stem cells that transmit the genetic material from generation to generation.Hence,it is essential to understand the similarities and differences between FGSCs and SSCs.In this study,we comprehensively compared the epigenetics of FGSCs and SSCs,including high-order chromatin organization,chromatin histone modification,and transcriptome by analyzing multiple-omics data(Hi-C,ChIP-seq,and RNA-seq).
