Keratin constitutes the major component of the feather,hair,hooves,horns,and wool represents a group of biological material having high cysteine content(7–13%)as compared to other structural proteins.Keratin-based bi...Keratin constitutes the major component of the feather,hair,hooves,horns,and wool represents a group of biological material having high cysteine content(7–13%)as compared to other structural proteins.Keratin-based biomaterials have been investigated extensively over the past few decades due to their intrinsic biological properties and excellent biocompatibility.Unlike other natural polymers such as starch,collagen,chitosan,the complex three-dimensional structure of keratin requires the use of harsh chemical conditions for their dissolution and extraction.The most commonly used methods for keratin extraction are oxidation,reduction,steam explosion,microbial method,microwave irradiation and use of ionic liquids.Keratin-based materials have been used extensively for various biomedical applications such as drug delivery,wound healing,tissue engineering.This review covers the structure,properties,history of keratin research,methods of extraction and some recent advancements related to the use of keratin derived biomaterials in the form of a 3-D scaffold,films,fibers,and hydrogels.展开更多
Metallic biomedical implants based on magnesium,zinc and iron alloys have emerged as bioresorbable alternatives to permanent orthopaedic implants over the last two decades.The corrosion rate of biodegradable metals pl...Metallic biomedical implants based on magnesium,zinc and iron alloys have emerged as bioresorbable alternatives to permanent orthopaedic implants over the last two decades.The corrosion rate of biodegradable metals plays a critical role in controlling the compatibility and functionality of the device in vivo.The broader adoption of biodegradable metals in orthopaedic applications depends on developing in vitro methods that accurately predict the biodegradation behaviour in vivo.However,the physiological environment is a highly complex corrosion environment to replicate in the laboratory,making the in vitro-to-in vivo translation of results very challenging.Accordingly,the results from in vitro corrosion tests fail to provide a complete schema of the biodegradation behaviour of the metal in vivo.In silico approach based on computer simulations aim to bridge the observed differences between experiments performed in vitro and vivo.A critical review of the state-of-the-art of computational modelling techniques for predicting the corrosion behaviour of magnesium alloy as a biodegradable metal is presented.展开更多
基金supported by Department of Anatomy,University of Otago,Otago,9016,New Zealand.
文摘Keratin constitutes the major component of the feather,hair,hooves,horns,and wool represents a group of biological material having high cysteine content(7–13%)as compared to other structural proteins.Keratin-based biomaterials have been investigated extensively over the past few decades due to their intrinsic biological properties and excellent biocompatibility.Unlike other natural polymers such as starch,collagen,chitosan,the complex three-dimensional structure of keratin requires the use of harsh chemical conditions for their dissolution and extraction.The most commonly used methods for keratin extraction are oxidation,reduction,steam explosion,microbial method,microwave irradiation and use of ionic liquids.Keratin-based materials have been used extensively for various biomedical applications such as drug delivery,wound healing,tissue engineering.This review covers the structure,properties,history of keratin research,methods of extraction and some recent advancements related to the use of keratin derived biomaterials in the form of a 3-D scaffold,films,fibers,and hydrogels.
基金supported by the Health Research Council of New Zealand.
文摘Metallic biomedical implants based on magnesium,zinc and iron alloys have emerged as bioresorbable alternatives to permanent orthopaedic implants over the last two decades.The corrosion rate of biodegradable metals plays a critical role in controlling the compatibility and functionality of the device in vivo.The broader adoption of biodegradable metals in orthopaedic applications depends on developing in vitro methods that accurately predict the biodegradation behaviour in vivo.However,the physiological environment is a highly complex corrosion environment to replicate in the laboratory,making the in vitro-to-in vivo translation of results very challenging.Accordingly,the results from in vitro corrosion tests fail to provide a complete schema of the biodegradation behaviour of the metal in vivo.In silico approach based on computer simulations aim to bridge the observed differences between experiments performed in vitro and vivo.A critical review of the state-of-the-art of computational modelling techniques for predicting the corrosion behaviour of magnesium alloy as a biodegradable metal is presented.
