期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Corneal collagen crosslinking in patients treated with dextran versus isotonic hydroxypropyl methylcellulose (HPMC) riboflavin solution: a retrospective analysis 被引量:1
1
作者 Patrick B.Rapuano Priya M.Mathews +2 位作者 george j.florakis Stephen L.Trokel Leejee H.Suh 《Eye and Vision》 SCIE 2018年第1期211-216,共6页
Background:Corneal collagen crosslinking(CXL)is a widely used treatment for halting the progression of keratoconus.Although initial studies of CXL were performed with a riboflavin solution containing dextran,recent pr... Background:Corneal collagen crosslinking(CXL)is a widely used treatment for halting the progression of keratoconus.Although initial studies of CXL were performed with a riboflavin solution containing dextran,recent protocols for CXL have indicated the use of a riboflavin solution containing isotonic hydroxypropyl methylcellulose(HPMC).This study was performed to investigate differences in visual outcomes and Scheimpflug(Pentacam)analysis in patients who have undergone epithelium-off CXL with riboflavin solution containing either 20%dextran versus 1.1%HPMC.Methods:All patients in this non-randomized,non-masked,retrospective cohort analysis were treated at Edward S.Harkness Eye Institute,Columbia University Medical Center,New York,NY,USA.Thirty-seven eyes of 33 patients were crosslinked with a dextran solution and 19 eyes of 19 patients crosslinked with an isotonic HPMC solution,both using an epithelium-off 30-min,3 mW/cm2 protocol.All patients had a diagnosis of keratoconus or postrefractive surgery ectasia.Best spectacle corrected visual acuity(BSCVA)and Pentacam parameters were compared at all follow up visits(1,6,12,and 24 months).Differences between groups treated with HPMC and dextran were compared using student’s t-test.Differences between treated eye and fellow eye were calculated and compared between HPMC and dextran groups using paired t-test.Results:Patients treated with a dextran solution had significantly greater improvement in BSCVA at 1,6,and 24 months(p<0.05)compared to the isotonic HPMC-treated group.Kmax increased in both groups at 1 month;however,HPMC-treated patients had a greater increase compared to dextran-treated patients(p=0.01).Kmax decreased in both groups at 6 and 12 months,although this finding was only significant in the HPMC-treated group at 12 months.Conclusions:Our data suggest that crosslinking with the dextran solution may result in significantly better visual outcomes(demonstrated by visual acuity)compared to the isotonic HPMC riboflavin solution.Dextran solutions may have other potential advantages intrinsic to its biochemical properties facilitating more efficient crosslinking.Further research and long-term evidence regarding the use of dextran versus HPMC riboflavin solutions in collagen crosslinking is necessary. 展开更多
关键词 Corneal crosslinking Isotonic HPMC DEXTRAN
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部