Alzheimer＇s disease（AD）is a fatal progressive neurodegenerative disorder characterized by loss in memory,cognition,and executive function and activities of daily living.AD pathogenesis has been shown to involve los...Alzheimer＇s disease（AD）is a fatal progressive neurodegenerative disorder characterized by loss in memory,cognition,and executive function and activities of daily living.AD pathogenesis has been shown to involve loss of neurons and synapses,cholinergic deficits,amyloid-beta protein（Aβ）deposition,tau protein hyperphosphorylation, and neuroinflammation.展开更多
Polyamines play preeminent roles in a variety of cellular functions in the central nervous system and other organs.A large body of evidence suggests that the polyamine pathway is prominently involved in the etiology a...Polyamines play preeminent roles in a variety of cellular functions in the central nervous system and other organs.A large body of evidence suggests that the polyamine pathway is prominently involved in the etiology and pathology of schizophrenia.Alterations in the expression and activity of polyamine metabolizing enzymes,as well as changes in the levels of the individual polyamines,their precursors and derivatives,have been measured in schizophrenia and animal models of the disease.Additionally,neuroleptic treatment has been shown to influence polyamine concentrations in brain and blood of individuals with schizophrenia.Thus,the polyamine system may appear to be a promising target for neuropharmacological treatment of schizophrenia.However,for a number of practical reasons there is currently only limited hope for a polyamine-based schizophrenia therapy.展开更多
文摘Alzheimer＇s disease（AD）is a fatal progressive neurodegenerative disorder characterized by loss in memory,cognition,and executive function and activities of daily living.AD pathogenesis has been shown to involve loss of neurons and synapses,cholinergic deficits,amyloid-beta protein（Aβ）deposition,tau protein hyperphosphorylation, and neuroinflammation.
文摘Polyamines play preeminent roles in a variety of cellular functions in the central nervous system and other organs.A large body of evidence suggests that the polyamine pathway is prominently involved in the etiology and pathology of schizophrenia.Alterations in the expression and activity of polyamine metabolizing enzymes,as well as changes in the levels of the individual polyamines,their precursors and derivatives,have been measured in schizophrenia and animal models of the disease.Additionally,neuroleptic treatment has been shown to influence polyamine concentrations in brain and blood of individuals with schizophrenia.Thus,the polyamine system may appear to be a promising target for neuropharmacological treatment of schizophrenia.However,for a number of practical reasons there is currently only limited hope for a polyamine-based schizophrenia therapy.
