The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance,especially in societies with a large elderly population.Self-assembled peptide hydrogels are a new generat...The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance,especially in societies with a large elderly population.Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility,tunable mechanical stability,injectability,trigger capability,lack of immunogenic reactions,and the ability to load cells and active pharmaceutical agents for tissue regeneration.Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals,which can mimic the extracellular matrix.Thus,peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods.This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration,including ionic self-complementary peptides,amphiphilic(surfactant-like)peptides,and triple-helix(collagen-like)peptides.Special attention is given to the main bioactive peptides,the role and importance of self-assembled peptide hydrogels,and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.展开更多
Regarding the increasing number of cancer patients,the global burden of this disease is continuing to grow.Despite a considerable improvement in the diagnosis and treatment of various types of cancer,new diagnosis and...Regarding the increasing number of cancer patients,the global burden of this disease is continuing to grow.Despite a considerable improvement in the diagnosis and treatment of various types of cancer,new diagnosis and treatment strategies are required.Nanotechnology,as an interesting and advanced field in medicine,is aimed to further advance both cancer diagnosis and treatment.Gold nanocages(AuNCs),with hollow interiors and porous walls,have received a great deal of interest in various biomedical applications such as diagnosis,imaging,drug delivery,and hyperthermia therapy due to their special physicochemical characteristics including the porous structure and surface functionalization as well as optical and photothermal properties.This review is focused on recent developments in therapeutic and diagnostic and applications of AuNCs with an emphasis on their theranostic applications in cancer diseases.展开更多
文摘The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance,especially in societies with a large elderly population.Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility,tunable mechanical stability,injectability,trigger capability,lack of immunogenic reactions,and the ability to load cells and active pharmaceutical agents for tissue regeneration.Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals,which can mimic the extracellular matrix.Thus,peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods.This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration,including ionic self-complementary peptides,amphiphilic(surfactant-like)peptides,and triple-helix(collagen-like)peptides.Special attention is given to the main bioactive peptides,the role and importance of self-assembled peptide hydrogels,and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.
文摘Regarding the increasing number of cancer patients,the global burden of this disease is continuing to grow.Despite a considerable improvement in the diagnosis and treatment of various types of cancer,new diagnosis and treatment strategies are required.Nanotechnology,as an interesting and advanced field in medicine,is aimed to further advance both cancer diagnosis and treatment.Gold nanocages(AuNCs),with hollow interiors and porous walls,have received a great deal of interest in various biomedical applications such as diagnosis,imaging,drug delivery,and hyperthermia therapy due to their special physicochemical characteristics including the porous structure and surface functionalization as well as optical and photothermal properties.This review is focused on recent developments in therapeutic and diagnostic and applications of AuNCs with an emphasis on their theranostic applications in cancer diseases.
