Statistical models provide a quantitative structure with which clinicians can evaluate their hypotheses to explain patterns in observed data and generate forecasts.In contrast,vitamin D is an important immune modulato...Statistical models provide a quantitative structure with which clinicians can evaluate their hypotheses to explain patterns in observed data and generate forecasts.In contrast,vitamin D is an important immune modulator that plays an emerging role in liver diseases such as chronic hepatitis B(CHB).Therefore,we quantified 25(OH)D_(3) serum levels in 292 CHB patients tested for their association with clinical parameters.Of 292 patients,69(63%),95(47%),and 39(19%)had severe vitamin D deficiency(25(OH)D_(3)<10 ng/mL),vitamin D insufficiency(25(OH)D_(3)10 and<20 ng/mL),or adequate vitamin D serum levels(25(OH)D_(3)20 ng/mL),respectively.In both univariate and multivariate analyses,zinc serum level was a strong predictor of low 25(OH)D_(3) serum levels(P<0.001).Results of fitted models showed that lower vitamin D levels were significantly associated with:younger age,lower uric acid levels,HBeAg-positive status,lower calcium levels(p<0.05).Vitamin D deficiency(<20 ng/ml)or severe deficiency(<10 ng/ml)was observed more frequently among HBV patients(52%).Vitamin D deficiency was observed in most CHB patients.Generally,our results recommend that substitution of vitamin D can be a substitution method in the treatment of patients with HBV-associated disorders.展开更多
文摘Statistical models provide a quantitative structure with which clinicians can evaluate their hypotheses to explain patterns in observed data and generate forecasts.In contrast,vitamin D is an important immune modulator that plays an emerging role in liver diseases such as chronic hepatitis B(CHB).Therefore,we quantified 25(OH)D_(3) serum levels in 292 CHB patients tested for their association with clinical parameters.Of 292 patients,69(63%),95(47%),and 39(19%)had severe vitamin D deficiency(25(OH)D_(3)<10 ng/mL),vitamin D insufficiency(25(OH)D_(3)10 and<20 ng/mL),or adequate vitamin D serum levels(25(OH)D_(3)20 ng/mL),respectively.In both univariate and multivariate analyses,zinc serum level was a strong predictor of low 25(OH)D_(3) serum levels(P<0.001).Results of fitted models showed that lower vitamin D levels were significantly associated with:younger age,lower uric acid levels,HBeAg-positive status,lower calcium levels(p<0.05).Vitamin D deficiency(<20 ng/ml)or severe deficiency(<10 ng/ml)was observed more frequently among HBV patients(52%).Vitamin D deficiency was observed in most CHB patients.Generally,our results recommend that substitution of vitamin D can be a substitution method in the treatment of patients with HBV-associated disorders.
