Implantable electrochemical microsensors are characterized by high sensitivity, while amperometric biosensors are very selective in virtue of the biological detecting element. Each sensor, specific for every neurochem...Implantable electrochemical microsensors are characterized by high sensitivity, while amperometric biosensors are very selective in virtue of the biological detecting element. Each sensor, specific for every neurochemical species, is a miniaturized hightechnology device resulting from the combination of several factors: electrode material, shielding polymers, applied electrochemical technique, and in the case of biosensors, biological sensing material, stabilizers, and entrapping chemical nets. In this paper, we summarizethe available technology for the in vivo electrochemical monitoring of neurotransmitters(dopamine, norepinephrine, serotonin, acetylcholine, and glutamate), bioenergetic substrates(glucose, lactate, and oxygen), neuromodulators(ascorbic acid and nitric oxide), and exogenous molecules such as ethanol. We also describe the most represented biotelemetric technologies in order to wirelessly transmit the signals of the abovelisted neurochemicals. Implantable(Bio)sensors, integrated into miniaturized telemetry systems, represent a new generation of analytical tools that could be used for studying the brain's physiology and pathophysiology and the effects of different drugs(or toxic chemicals such as ethanol) on neurochemical systems.展开更多
基金Supported by The Regione autonoma della Sardegna(fund P.O.R.SARDEGNA F.S.E.2007-2013-Obiettivo competitività regionale e occupazione,Asse ⅣCapitale umano,Linea di Attivitàl.3.1)
文摘Implantable electrochemical microsensors are characterized by high sensitivity, while amperometric biosensors are very selective in virtue of the biological detecting element. Each sensor, specific for every neurochemical species, is a miniaturized hightechnology device resulting from the combination of several factors: electrode material, shielding polymers, applied electrochemical technique, and in the case of biosensors, biological sensing material, stabilizers, and entrapping chemical nets. In this paper, we summarizethe available technology for the in vivo electrochemical monitoring of neurotransmitters(dopamine, norepinephrine, serotonin, acetylcholine, and glutamate), bioenergetic substrates(glucose, lactate, and oxygen), neuromodulators(ascorbic acid and nitric oxide), and exogenous molecules such as ethanol. We also describe the most represented biotelemetric technologies in order to wirelessly transmit the signals of the abovelisted neurochemicals. Implantable(Bio)sensors, integrated into miniaturized telemetry systems, represent a new generation of analytical tools that could be used for studying the brain's physiology and pathophysiology and the effects of different drugs(or toxic chemicals such as ethanol) on neurochemical systems.
