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Steroids and plasma exchange in Isaacs' syndromewith anti-Caspr2 antibodies
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作者 Daniele Orsucci gianfranco cafforio +3 位作者 Gianluca Moscato Alessandro Napolitano Marco Margelli Monica Mazzoni 《Neuroimmunology and Neuroinflammation》 2018年第3期5-9,共5页
Isaacs' syndrome is a disease characterized by nerve hyperexcitability. The patients are commonly treated with symptomatic therapies and immunomodulatory approaches, but no clinical trials are available to date. H... Isaacs' syndrome is a disease characterized by nerve hyperexcitability. The patients are commonly treated with symptomatic therapies and immunomodulatory approaches, but no clinical trials are available to date. Here, we report the case of an anti-Caspr2-positive patient, presenting with continuous muscle twitches and diffuse muscle pain. He experienced a nearly complete clinical response to intravenous high-dose steroids combined with plasma exchange, sustained for at least 1 year. Our experience suggests that methylprednisolone 1000 mg/day × 5 days and consecutive tapering followed by plasma exchange may be efficient and well tolerated in patient with Isaacs' syndrome due to anti-Caspr2 antibodies. 展开更多
关键词 Contactin-associated protein-2 ISAAC NEUROMUSCULAR HYPEREXCITABILITY NEUROMYOTONIA VOLTAGE-GATED potassium channel
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