Neurons are energy-demanding cells.Disruptions in energy metabolism can quickly interrupt neuronal function,leading to cell death and neurodegeneration.For instance,ischemia rapidly depletes adenosine triphosphate(ATP...Neurons are energy-demanding cells.Disruptions in energy metabolism can quickly interrupt neuronal function,leading to cell death and neurodegeneration.For instance,ischemia rapidly depletes adenosine triphosphate(ATP)thereby disrupting energy-dependent cellular processes crucial for homeostasis,and axon degeneration is preceded by a collapse of axonal ATP levels.展开更多
The formation of branches during development allows a single axon to make synaptic contacts with numerous target neurons,often in different parts of the nervous system,thereby allowing for the establishment of complex...The formation of branches during development allows a single axon to make synaptic contacts with numerous target neurons,often in different parts of the nervous system,thereby allowing for the establishment of complex patterns of neuronal connectivity.展开更多
The ability of the axon to form de novo collateral branches along its length is fundamental to the establishment of complex patterns of connectivity during development and is also a major response of many axonal popul...The ability of the axon to form de novo collateral branches along its length is fundamental to the establishment of complex patterns of connectivity during development and is also a major response of many axonal populations following injury.The emergence of branches is under both positive and negative control by extracellular signals.展开更多
基金supported by National Institute of Health awards NS118000 and NS128049 (to GG)。
文摘Neurons are energy-demanding cells.Disruptions in energy metabolism can quickly interrupt neuronal function,leading to cell death and neurodegeneration.For instance,ischemia rapidly depletes adenosine triphosphate(ATP)thereby disrupting energy-dependent cellular processes crucial for homeostasis,and axon degeneration is preceded by a collapse of axonal ATP levels.
文摘The formation of branches during development allows a single axon to make synaptic contacts with numerous target neurons,often in different parts of the nervous system,thereby allowing for the establishment of complex patterns of neuronal connectivity.
文摘The ability of the axon to form de novo collateral branches along its length is fundamental to the establishment of complex patterns of connectivity during development and is also a major response of many axonal populations following injury.The emergence of branches is under both positive and negative control by extracellular signals.
