The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect...The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.展开更多
Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient times.The Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids c...Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient times.The Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids consisting of Δ9-tetrahydrocannabinol(THC),the psychoactive constituent,and cannabidiol(CBD),which does not bear this effect.This paper aims at providing a perspective on the potential therapeutic effects of CBD based on its preferential interaction with transient potential receptor V2(TRPV2).Many formulations based on Cannabis extract have been licensed for therapeutic use in some Western countries.Among these,the most relevant are Sativex(THC+CBD,used mainly for the treatment of spasticity in multiple sclerosis)and Epidyolex(purified plant-derived CBD,used for some rare childhood epilepsies).展开更多
文摘The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.
文摘Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient times.The Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids consisting of Δ9-tetrahydrocannabinol(THC),the psychoactive constituent,and cannabidiol(CBD),which does not bear this effect.This paper aims at providing a perspective on the potential therapeutic effects of CBD based on its preferential interaction with transient potential receptor V2(TRPV2).Many formulations based on Cannabis extract have been licensed for therapeutic use in some Western countries.Among these,the most relevant are Sativex(THC+CBD,used mainly for the treatment of spasticity in multiple sclerosis)and Epidyolex(purified plant-derived CBD,used for some rare childhood epilepsies).
