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Histo-molecular oncogenesis of pancreatic cancer:From precancerous lesions to invasive ductal adenocarcinoma
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作者 Giulio Riva Antonio Pea +4 位作者 Camilla Pilati giulia fiadone Rita Teresa Lawlor Aldo Scarpa Claudio Luchini 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2018年第10期317-327,共11页
Pancreatic cancer is a lethal malignancy,whose precursor lesions are pancreatic intraepithelial neoplasm,intraductal papillary mucinous neoplasm,intraductal tubulopapillary neoplasm,and mucinous cystic neoplasm.To bet... Pancreatic cancer is a lethal malignancy,whose precursor lesions are pancreatic intraepithelial neoplasm,intraductal papillary mucinous neoplasm,intraductal tubulopapillary neoplasm,and mucinous cystic neoplasm.To better understand the biology of pancreatic cancer,it is fundamental to know its precursors and to study the mechanisms of carcinogenesis.Each of these precursors displays peculiar histological features,as well as specific molecular alterations.Starting from such pre-invasive lesions,this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer,with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type. 展开更多
关键词 ONCOGENESIS INTRADUCTAL papillary MUCINOUS NEOPLASM MUCINOUS cystic NEOPLASM PANCREATIC DUCTAL adenocarcinoma PANCREATIC intraepithelial NEOPLASM KRAS Carcinogenesis PANCREATIC cancer INTRADUCTAL tubulopapillary NEOPLASM
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