The purpose of this study was to evaluate the diagnostic value of an interleukin- 6 (IL- 6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospectiv...The purpose of this study was to evaluate the diagnostic value of an interleukin- 6 (IL- 6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospective clinical study included 73 patients. Interleukin- 6 protein in vaginal secretions was determined with an immunochromatographic bedside test in < 20 minutes. Elevated C- reactive protein level (>20 mg/dL; odds ratio, 5.1; 95% CI, 0.9- 28.6) and positive interleukin- 6 level (odds ratio, 4.6; 95% CI, 1.2- 18.4) were both associated with neonatal infection. After adjustment, only interleukin- 6 remained associated with neonatal infection (odds ratio, 4.5; 95% CI, 1.1- 18.5). The sensitivity of interleukin- 6 for the prediction of neonatal infection was 79% (95% CI, 65- 92); its specificity was 56% (95% CI, 42- 70); its positive predictive value was 30% (95% CI, 12- 47), and its negative predictive value was 92% (95% CI, 84- 99). Interleukin- 6 protein determination by this new immunochromatographic test is a noninvasive prenatal vaginal marker of neonatal infection.展开更多
Objective This study was undertaken to determine maternal and perinat al outcom es after expectant management of severe preeclampsia between 24 and 33 weeksge station. Study design A prospective observational study ...Objective This study was undertaken to determine maternal and perinat al outcom es after expectant management of severe preeclampsia between 24 and 33 weeksge station. Study design A prospective observational study of 239 women with severe preeclamptic and undelivered after antenatal steroid prophylaxis was performed. Pregnancy prolongation and maternal and perinatal morbidities were analyzed acc ording to the gestational age at time of expectant management: 24 to 28, 29 to 3 1, and 32 to 33 weeks. Statistical analysis was performed by Student t test and χ2 test. Results The days of pregnancy prolongation were significantly higher a mong those managed at less than 29 weeks (6) compared with the other groups (4). There were 13 perinatal deaths: 12 in those managed at less than 29 weeks and 1 in those managed at 29 to 31 weeks. Neonatal morbidities were significantly hig her among those managed at less than 29 weeks compared with the other groups. Th ere were no instances of maternal death or eclampsia. Maternal morbidities were similar among the groups. Conclusion Expectant management of severe preeclampsia at 24 to 33 weeks in a tertiary care center is associated with good perinatal o utcome with a minimal risk for the mother.展开更多
文摘The purpose of this study was to evaluate the diagnostic value of an interleukin- 6 (IL- 6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospective clinical study included 73 patients. Interleukin- 6 protein in vaginal secretions was determined with an immunochromatographic bedside test in < 20 minutes. Elevated C- reactive protein level (>20 mg/dL; odds ratio, 5.1; 95% CI, 0.9- 28.6) and positive interleukin- 6 level (odds ratio, 4.6; 95% CI, 1.2- 18.4) were both associated with neonatal infection. After adjustment, only interleukin- 6 remained associated with neonatal infection (odds ratio, 4.5; 95% CI, 1.1- 18.5). The sensitivity of interleukin- 6 for the prediction of neonatal infection was 79% (95% CI, 65- 92); its specificity was 56% (95% CI, 42- 70); its positive predictive value was 30% (95% CI, 12- 47), and its negative predictive value was 92% (95% CI, 84- 99). Interleukin- 6 protein determination by this new immunochromatographic test is a noninvasive prenatal vaginal marker of neonatal infection.
文摘Objective This study was undertaken to determine maternal and perinat al outcom es after expectant management of severe preeclampsia between 24 and 33 weeksge station. Study design A prospective observational study of 239 women with severe preeclamptic and undelivered after antenatal steroid prophylaxis was performed. Pregnancy prolongation and maternal and perinatal morbidities were analyzed acc ording to the gestational age at time of expectant management: 24 to 28, 29 to 3 1, and 32 to 33 weeks. Statistical analysis was performed by Student t test and χ2 test. Results The days of pregnancy prolongation were significantly higher a mong those managed at less than 29 weeks (6) compared with the other groups (4). There were 13 perinatal deaths: 12 in those managed at less than 29 weeks and 1 in those managed at 29 to 31 weeks. Neonatal morbidities were significantly hig her among those managed at less than 29 weeks compared with the other groups. Th ere were no instances of maternal death or eclampsia. Maternal morbidities were similar among the groups. Conclusion Expectant management of severe preeclampsia at 24 to 33 weeks in a tertiary care center is associated with good perinatal o utcome with a minimal risk for the mother.
