Birt-Hogg-Dubésyndrome (BHDS) is an uncommon autosomal dominant genodermatosis characterized by a triad of skin tumors-fibrofolliculomas, trichodiscomas, and acrochordons-together with an increased risk of renal ...Birt-Hogg-Dubésyndrome (BHDS) is an uncommon autosomal dominant genodermatosis characterized by a triad of skin tumors-fibrofolliculomas, trichodiscomas, and acrochordons-together with an increased risk of renal tumors and spontaneous pneumothoraces. This report describes multiple facial angiofi-bromas as the predominant initial manifestation of BHDS. The patient had a total of 41 facial papules removed via shave excision, initially for diagnostic and then for therapeutic purposes; histologic evaluation revealed diagnostic features of angiofi-broma in 39 lesions and fibrofolliculoma in only 2. BHDS should be considered, along with tuberous sclerosis and multiple endocrine neoplasia type 1, in the differential diagnosis of multiple facial angiofibromas, particularly when onset is in adulthood.展开更多
文摘Birt-Hogg-Dubésyndrome (BHDS) is an uncommon autosomal dominant genodermatosis characterized by a triad of skin tumors-fibrofolliculomas, trichodiscomas, and acrochordons-together with an increased risk of renal tumors and spontaneous pneumothoraces. This report describes multiple facial angiofi-bromas as the predominant initial manifestation of BHDS. The patient had a total of 41 facial papules removed via shave excision, initially for diagnostic and then for therapeutic purposes; histologic evaluation revealed diagnostic features of angiofi-broma in 39 lesions and fibrofolliculoma in only 2. BHDS should be considered, along with tuberous sclerosis and multiple endocrine neoplasia type 1, in the differential diagnosis of multiple facial angiofibromas, particularly when onset is in adulthood.
