Objective: The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third- trimester stillbirth. Study design: Case subjects were 37 women with a history of a third- t...Objective: The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third- trimester stillbirth. Study design: Case subjects were 37 women with a history of a third- trimester unexplained stillbirth. Control subjects were 46 volunteers, group- matched for ethnic origin, with no history of stillbirth, recurrent fetal loss, or thromboembolism. The pathology report of 34/37 placentas of case subjects was reviewed. Results: The prevalence of at least 1 inherited thrombophilia among case subjects was 37.8% compared with 41.3% among control subjects. (OR = 0.87; 95% CI, 0.32- 2.29). There was no significant difference between the groups with respect to the prevalence of any single inherited thrombophilia. There was, however, a significantly higher prevalence of antiphospholipid antibodies among case subjects compared with control subjects: 47.2% vs 8.7% , respectively (OR = 9.4; 95% CI, 2.5- 42.3). No significant difference was noted in the prevalence of thrombopilia among subjects with or without placental infarcts. Conclusion: We did not find an association between unexplained third- trimester intrauterine fetal death and inherited thrombophilia; however, we did find such an association with antiphospholipid antibodies.展开更多
BACKGROUND: Hepatopulmonary syndrome is an uncommon complication of liver cirrhosis. The natural history of this condition and its optimal management during pregnancy are not yet known. CASE: We present the case of a ...BACKGROUND: Hepatopulmonary syndrome is an uncommon complication of liver cirrhosis. The natural history of this condition and its optimal management during pregnancy are not yet known. CASE: We present the case of a 35-year-old woman with liver cirrhosis who developed severe dyspnea in the 25th week of gestation and was diagnosed as suffering from hepatopulmonary syndrome. She was managed conservatively until 35 weeks of gestation,when shewas delivered by cesarean. CONCLUSION: The natural history, in this case, indicates that pregnancy may induce hepatopulmonary syndrome in an otherwise asymptomatic cirrhotic patient. Oxygen supplementation was the cornerstone of treatment and resulted in a favorable outcome.展开更多
文摘Objective: The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third- trimester stillbirth. Study design: Case subjects were 37 women with a history of a third- trimester unexplained stillbirth. Control subjects were 46 volunteers, group- matched for ethnic origin, with no history of stillbirth, recurrent fetal loss, or thromboembolism. The pathology report of 34/37 placentas of case subjects was reviewed. Results: The prevalence of at least 1 inherited thrombophilia among case subjects was 37.8% compared with 41.3% among control subjects. (OR = 0.87; 95% CI, 0.32- 2.29). There was no significant difference between the groups with respect to the prevalence of any single inherited thrombophilia. There was, however, a significantly higher prevalence of antiphospholipid antibodies among case subjects compared with control subjects: 47.2% vs 8.7% , respectively (OR = 9.4; 95% CI, 2.5- 42.3). No significant difference was noted in the prevalence of thrombopilia among subjects with or without placental infarcts. Conclusion: We did not find an association between unexplained third- trimester intrauterine fetal death and inherited thrombophilia; however, we did find such an association with antiphospholipid antibodies.
文摘BACKGROUND: Hepatopulmonary syndrome is an uncommon complication of liver cirrhosis. The natural history of this condition and its optimal management during pregnancy are not yet known. CASE: We present the case of a 35-year-old woman with liver cirrhosis who developed severe dyspnea in the 25th week of gestation and was diagnosed as suffering from hepatopulmonary syndrome. She was managed conservatively until 35 weeks of gestation,when shewas delivered by cesarean. CONCLUSION: The natural history, in this case, indicates that pregnancy may induce hepatopulmonary syndrome in an otherwise asymptomatic cirrhotic patient. Oxygen supplementation was the cornerstone of treatment and resulted in a favorable outcome.
