Neuroinflammation is implicated in the pathophysiology of depression. The reduction of hippocampal volume indepression remains controversial because of interindividual variability in clinical studies. Herein, we studi...Neuroinflammation is implicated in the pathophysiology of depression. The reduction of hippocampal volume indepression remains controversial because of interindividual variability in clinical studies. Herein, we studied theeffects of clomipramine, a tricyclic antidepressant (TCA) that modulates serotonin and norepinephrine uptake, onchronic mild unpredictable stress (CMS) induced depressive-like behaviors, hippocampal neuroinflammation, and hippocampal volume. Using a rat model of CMS induced depression, we administered clomipramine every day for4 weeks, starting 8 weeks after the beginning of the CMS procedure. Behavioral changes were measured by forcedswim test, open field test, and elevated plus maze. Neuroinflammation in the hippocampus was assessed byimmunohistochemistry, Western blot analysis, and quantitative polymerase chain reaction. Hippocampal volumeswere dynamically measured using T2- weighted imaging with 7T structural magnetic resonance imaging.展开更多
Neuroinflammation is implicated in the pathophysiology of depression.The reduction of hippocampal volume in depression remains controversial because of interindividual variability in clinical studies.Herein,we studied...Neuroinflammation is implicated in the pathophysiology of depression.The reduction of hippocampal volume in depression remains controversial because of interindividual variability in clinical studies.Herein,we studied the effects of clomipramine,a tricyclic antidepressant(TCA)that modulates serotonin and norepinephrine uptake,on chronic mild unpredictable stress(CMS)-induced depressive-like behaviors,hippocampal neuroinflammation,and hippocampal volume.展开更多
文摘Neuroinflammation is implicated in the pathophysiology of depression. The reduction of hippocampal volume indepression remains controversial because of interindividual variability in clinical studies. Herein, we studied theeffects of clomipramine, a tricyclic antidepressant (TCA) that modulates serotonin and norepinephrine uptake, onchronic mild unpredictable stress (CMS) induced depressive-like behaviors, hippocampal neuroinflammation, and hippocampal volume. Using a rat model of CMS induced depression, we administered clomipramine every day for4 weeks, starting 8 weeks after the beginning of the CMS procedure. Behavioral changes were measured by forcedswim test, open field test, and elevated plus maze. Neuroinflammation in the hippocampus was assessed byimmunohistochemistry, Western blot analysis, and quantitative polymerase chain reaction. Hippocampal volumeswere dynamically measured using T2- weighted imaging with 7T structural magnetic resonance imaging.
文摘Neuroinflammation is implicated in the pathophysiology of depression.The reduction of hippocampal volume in depression remains controversial because of interindividual variability in clinical studies.Herein,we studied the effects of clomipramine,a tricyclic antidepressant(TCA)that modulates serotonin and norepinephrine uptake,on chronic mild unpredictable stress(CMS)-induced depressive-like behaviors,hippocampal neuroinflammation,and hippocampal volume.
