Hepatic encephalopathy is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction,after exclusion of brain disease.Despite extensive scientific research,the pathogenesis of hepatic e...Hepatic encephalopathy is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction,after exclusion of brain disease.Despite extensive scientific research,the pathogenesis of hepatic encephalopathy is still unknown,and the most classic hypothesis is the theory of ammonia intoxication.Currently available evidence suggests that clinical hepatic encephalopathy cause impairments of astrocytic function resulting in neuronal dysfunction.In this study standardize an animal model of HE induced by thioacetamide(TAA)in C57BL/6 mice evaluating behavioral symptoms,and we performed immunofluorescence staining,whole cell patch clamp recording,Golgi staining.展开更多
The polynomial-like iterative equation is an important form of functional equations, in which iterates of the unknown function are linked in a linear combination. Most of known results were given for the given functio...The polynomial-like iterative equation is an important form of functional equations, in which iterates of the unknown function are linked in a linear combination. Most of known results were given for the given function to be monotone. We discuss this equation for continuous solutions in the case that the given function is a PM(piecewise monotone) function, a special class of non-monotonic functions. Using extension method, we give a general construction of solutions for the polynomial-like iterative equation.展开更多
文摘Hepatic encephalopathy is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction,after exclusion of brain disease.Despite extensive scientific research,the pathogenesis of hepatic encephalopathy is still unknown,and the most classic hypothesis is the theory of ammonia intoxication.Currently available evidence suggests that clinical hepatic encephalopathy cause impairments of astrocytic function resulting in neuronal dysfunction.In this study standardize an animal model of HE induced by thioacetamide(TAA)in C57BL/6 mice evaluating behavioral symptoms,and we performed immunofluorescence staining,whole cell patch clamp recording,Golgi staining.
基金supported by National Natural Science Foundation of China (Grant No. 11501471)Fundamental Research Funds for the Central Universities (Grant No. 2682015BR017)
文摘The polynomial-like iterative equation is an important form of functional equations, in which iterates of the unknown function are linked in a linear combination. Most of known results were given for the given function to be monotone. We discuss this equation for continuous solutions in the case that the given function is a PM(piecewise monotone) function, a special class of non-monotonic functions. Using extension method, we give a general construction of solutions for the polynomial-like iterative equation.
