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CBA、C57BL/6bkl小鼠对脉冲性噪音损伤敏感性的研究 被引量:2
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作者 童步升 Malou Hultcranz +1 位作者 goran laurell 段茂利 《安徽医科大学学报》 CAS 北大核心 2006年第3期254-257,共4页
目的研究CBA、C57BL/6bkl小鼠对脉冲性噪音损伤的敏感性。方法小鼠共分为8组,第1、2、3组为CBA小鼠(n分别为9、10、10)分别给予160dBSPL50、100、150次脉冲噪音暴露,第4、5、6组为C57BL/6bkl小鼠(n皆为10),分别给予160dBSPL50、100、15... 目的研究CBA、C57BL/6bkl小鼠对脉冲性噪音损伤的敏感性。方法小鼠共分为8组,第1、2、3组为CBA小鼠(n分别为9、10、10)分别给予160dBSPL50、100、150次脉冲噪音暴露,第4、5、6组为C57BL/6bkl小鼠(n皆为10),分别给予160dBSPL50、100、150次脉冲噪音暴露,第7、8组为CBA和C57BL/6bkl小鼠对照组(n=10),无噪音暴露。在噪音暴露前、噪音后24h及28d测听觉脑干诱发电位。结果给予160dBSPL50次脉冲噪音暴露后,CBA只出现暂时性阈值漂移,C57BL/6bkl出现暂时性和永久的阈值漂移,给予160dB100次和150次脉冲噪音暴露后,CBA和C57BL/6bkl均出现暂时性和永久性阈值漂移。对照组无阈值漂移。结论C57BL/6bkl小鼠对脉冲性噪音更敏感,耳蜗铺片形态学亦支持上述结论。 展开更多
关键词 噪音/副作用 听力障碍/诊断 诱发电位
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A morphometric study of the structures bordering the infra-cochlear corridor-Relevant for endoscopic/microscopic ear surgery 被引量:2
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作者 Wei Liu Yongtian Lu +1 位作者 goran laurell Vincent Cousins 《Journal of Otology》 CSCD 2018年第3期81-84,共4页
Application of surgical endoscope, used alone or in combination with the surgical microscope, for the operative management of ear and temporal bone conditions may allow improved access and clearance of disease. Preser... Application of surgical endoscope, used alone or in combination with the surgical microscope, for the operative management of ear and temporal bone conditions may allow improved access and clearance of disease. Preservation of normal structures may also be improved.As the use of this tool is increasing, the need for better understanding of the anatomy of the ear is becoming evident. This is particularly so for endoscopic surgery aiming at removal of lesions involving the infra-cochlear corridor and/or petrous apex.Human temporal bone-derived labyrinth casts(molds), originally made for endolymphatic duct and sac analysis which genuinely represent the membranous labyrinth and its adjacent soft tissues, were morphometrically analyzed in terms of the anatomic relations between structures in and around the infra-cochlear corridor. The distance between the petrous carotid artery(PCA) and the basal turn of the cochlea, the distance between PCA and infra-cochlear vein(ICV)/cochlear aqueduct(CA), and the distance between the lower surface of basal cochlear turn and the point where the carotid artery and jugular vein(JV) meet close to the jugular foramen, were measured to be around 1.3 mm, 6 mm and 8 mm respectively, thus constituting an approximate 6?8 mm2 infra-cochlear corridor. This analysis and further study with larger samples might be helpful for operation via this corridor led to the petrous apex where cholesterol granuloma, cholesteatoma and other lesions are not uncommon. 展开更多
关键词 Infra-cochlear CORRIDOR Petrous APEX ANATOMICAL study EAR ENDOSCOPY Surgery
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