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Apoer2/Lrp8:the undercover cop of synaptic homeostasis
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作者 gordon c.werthmann Joachim Herz 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2563-2564,共2页
Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through ... Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric disorders.In this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus. 展开更多
关键词 HOMEOSTASIS APOE ALZHEIMER
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