Due to high ring strain energies,cyclopropanols and cyclobutanols have a strong tendency of breaking theendocyclic C–C bonds to participate in versatile organic transformations.With an inherent three-dimensionalstruc...Due to high ring strain energies,cyclopropanols and cyclobutanols have a strong tendency of breaking theendocyclic C–C bonds to participate in versatile organic transformations.With an inherent three-dimensionalstructure,cyclopropanols and cyclobutanols have the advantage of synthesizing linear or cyclic molecules withstereogenic centers via ring-opening asymmetric synthesis.There are three strategies for the ring-opening ofcyclopropanols and cyclobutanols usually involved in asymmetric synthesis:1)β-carbon elimination of metalalkoxide;2)radical ring-opening;3)ring-opening via semipinacol rearrangement.The present review has high-lighted the progress developed in the last five years.展开更多
基金Financial support from the Fuzhou University(No.0041/511095)is gratefully acknowledged.We also thank Liuhui Xu for drawing many chemical structures.
文摘Due to high ring strain energies,cyclopropanols and cyclobutanols have a strong tendency of breaking theendocyclic C–C bonds to participate in versatile organic transformations.With an inherent three-dimensionalstructure,cyclopropanols and cyclobutanols have the advantage of synthesizing linear or cyclic molecules withstereogenic centers via ring-opening asymmetric synthesis.There are three strategies for the ring-opening ofcyclopropanols and cyclobutanols usually involved in asymmetric synthesis:1)β-carbon elimination of metalalkoxide;2)radical ring-opening;3)ring-opening via semipinacol rearrangement.The present review has high-lighted the progress developed in the last five years.
