Structures in nature are often multi-material,and their structures have afine bal-ance between segregation and aggregation(mixed,but not scrambled)that provides functionality.Chaotic fabrication,a technology that explo...Structures in nature are often multi-material,and their structures have afine bal-ance between segregation and aggregation(mixed,but not scrambled)that provides functionality.Chaotic fabrication,a technology that exploits the ability of chaotic advection to create predictable and reproducible multilayered structures,excels at producing materials where this balance can be achieved andfinely tuned.This method is based on the use of chaotic mixing systems,which can produce constructs with highly organized internal micro-architecture in a simple and cost-effective way.This manuscript provides a perspective on how chaotic printing can be a great enabler in the manufacture of advanced materials,including living tissues.Chaotic printing may overcome many of the critical hurdles that are currently faced in man-ufacturing and biofabrication(e.g.,creating a wide array of interfaces,reaching high resolutions rapidly and at low cost,and producing densely vascularized tissues).The manuscript introduces the technology,explains how the idea originated,presents a timeline that provides a recapitulation of the milestones achieved so far,describes the main characteristics,advantages,limitations,and challenges of the technology,and concludes with future perspectives on the evolution and use of this versatile method.展开更多
基金CONAHCyT,Grant/Award Numbers:SNI 26048,SNI 256730Baur ChairChallenge-Based Research Funding Program。
文摘Structures in nature are often multi-material,and their structures have afine bal-ance between segregation and aggregation(mixed,but not scrambled)that provides functionality.Chaotic fabrication,a technology that exploits the ability of chaotic advection to create predictable and reproducible multilayered structures,excels at producing materials where this balance can be achieved andfinely tuned.This method is based on the use of chaotic mixing systems,which can produce constructs with highly organized internal micro-architecture in a simple and cost-effective way.This manuscript provides a perspective on how chaotic printing can be a great enabler in the manufacture of advanced materials,including living tissues.Chaotic printing may overcome many of the critical hurdles that are currently faced in man-ufacturing and biofabrication(e.g.,creating a wide array of interfaces,reaching high resolutions rapidly and at low cost,and producing densely vascularized tissues).The manuscript introduces the technology,explains how the idea originated,presents a timeline that provides a recapitulation of the milestones achieved so far,describes the main characteristics,advantages,limitations,and challenges of the technology,and concludes with future perspectives on the evolution and use of this versatile method.
