Crosslinked N, O-carboxymethyl chitosan resins which can selectively adsorb triglyceride, were prepared by the reaction of N, O- carboxymethyl chitosan with glutaraldehyde solution. Adsorption experiments were perform...Crosslinked N, O-carboxymethyl chitosan resins which can selectively adsorb triglyceride, were prepared by the reaction of N, O- carboxymethyl chitosan with glutaraldehyde solution. Adsorption experiments were performed by adding the resins to the serum. The results showed that this type of adsorbent could cut down the concentration of triglyceride in serum by 56. 4% (3. 35mg/gresin ) at most, while concentration of the total protein (TP ) decreased only by 10. 9% at least, so this novel adsorbent can be used to cure hypertriglyceridemia by hemoperfusion in the future.展开更多
The wettability and surface structure of plasma treatment on medical polyurethane were studied.Two kinds of gas,N_(2),Ar,were used to create the dow-temperature plasma under low pressure.The wettability was investigat...The wettability and surface structure of plasma treatment on medical polyurethane were studied.Two kinds of gas,N_(2),Ar,were used to create the dow-temperature plasma under low pressure.The wettability was investigated by means of the sessile drop method using water,the results show that the contact angle of water decreases from 78.8°to 61.9°as the treatment time increases.The results of electron spectroscopy for chemical analysis indicate that original chemical bonds were broken up after plasma,treatment,which was the main reason for the surface modificatioii.At same time,the results of electron spinning resonance show that the amounts of radicals did not increase significantly after treatment,which is advantageous to clinical practice of polyurethane.展开更多
A series of uncharged, anionic, cationic, and heparinized polyetherurethanes(PEUs) was synthesized. The soft segments of these PEUs were respectively obtained by polyte-tramethylene oxide of molecular weight 1000 (PTM...A series of uncharged, anionic, cationic, and heparinized polyetherurethanes(PEUs) was synthesized. The soft segments of these PEUs were respectively obtained by polyte-tramethylene oxide of molecular weight 1000 (PTMO-1000), polythylene glycol of molecularweight 1000 (PEG-1000), PEG-4000, and the mixture of PEG-4000 with PTMO-1000 orPEG-1000. The hard segments consisted of 4,4’ -methylene diphenylene diisocyanate (MDI)which was extended with ethylenediamie (ED), 1,4Mbutanediol (BD), N-methyldiethanolamine(MDEA), or L-Sodium α,ε-diaminocaproate (SDAC), respectively. The chemical structure of different PEUs was confirmed by nuclear magnetic resonance. Waterabsorptions were measured. The results showed that the ionic, heparinized PEUs, and the PEUscontained PEG-4000 as soft segments have higher water absorptions than ordinary PEUs. ThePEUs based mainly on PEG-4000 as soft segments are a kind of high hydroscopic polymer mate-rials, and their hydroscopicity increases with PEG-4000 in soft segment.展开更多
Carbon nitride （CN,） and diamond-like carbon （DLC） coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship ...Carbon nitride （CN,） and diamond-like carbon （DLC） coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of ni- trogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.1〉 the CN0.22 coating showed longer dynamic clotting time （about 42 min）, static clotting time （23.6 min） and recalcification time （45.6 s）, as well as lower platelet adhesion （102 cells μm-2）, aggregation, and activation. The presence of nitrogen in the CNx coatings in- duced their enhanced hemocompatibility compared with DLC.展开更多
文摘Crosslinked N, O-carboxymethyl chitosan resins which can selectively adsorb triglyceride, were prepared by the reaction of N, O- carboxymethyl chitosan with glutaraldehyde solution. Adsorption experiments were performed by adding the resins to the serum. The results showed that this type of adsorbent could cut down the concentration of triglyceride in serum by 56. 4% (3. 35mg/gresin ) at most, while concentration of the total protein (TP ) decreased only by 10. 9% at least, so this novel adsorbent can be used to cure hypertriglyceridemia by hemoperfusion in the future.
基金Supported by the Youth Science Foundation of China。
文摘The wettability and surface structure of plasma treatment on medical polyurethane were studied.Two kinds of gas,N_(2),Ar,were used to create the dow-temperature plasma under low pressure.The wettability was investigated by means of the sessile drop method using water,the results show that the contact angle of water decreases from 78.8°to 61.9°as the treatment time increases.The results of electron spectroscopy for chemical analysis indicate that original chemical bonds were broken up after plasma,treatment,which was the main reason for the surface modificatioii.At same time,the results of electron spinning resonance show that the amounts of radicals did not increase significantly after treatment,which is advantageous to clinical practice of polyurethane.
文摘A series of uncharged, anionic, cationic, and heparinized polyetherurethanes(PEUs) was synthesized. The soft segments of these PEUs were respectively obtained by polyte-tramethylene oxide of molecular weight 1000 (PTMO-1000), polythylene glycol of molecularweight 1000 (PEG-1000), PEG-4000, and the mixture of PEG-4000 with PTMO-1000 orPEG-1000. The hard segments consisted of 4,4’ -methylene diphenylene diisocyanate (MDI)which was extended with ethylenediamie (ED), 1,4Mbutanediol (BD), N-methyldiethanolamine(MDEA), or L-Sodium α,ε-diaminocaproate (SDAC), respectively. The chemical structure of different PEUs was confirmed by nuclear magnetic resonance. Waterabsorptions were measured. The results showed that the ionic, heparinized PEUs, and the PEUscontained PEG-4000 as soft segments have higher water absorptions than ordinary PEUs. ThePEUs based mainly on PEG-4000 as soft segments are a kind of high hydroscopic polymer mate-rials, and their hydroscopicity increases with PEG-4000 in soft segment.
基金supported by the National Basic Research Program of China (Grant No. 2012CB933604)the National Natural Science Foundation of China (Grant No. 11075116),the National Natural Science Foundation of China "The effect of functionalization induced by ion beam on cell and blood compatibility of graphene" (2013)+1 种基金the Open Research Fund of the State Key Laboratory of Bioelectronics, Southeast Universitythe Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Beijing Normal University, China
文摘Carbon nitride （CN,） and diamond-like carbon （DLC） coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of ni- trogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.1〉 the CN0.22 coating showed longer dynamic clotting time （about 42 min）, static clotting time （23.6 min） and recalcification time （45.6 s）, as well as lower platelet adhesion （102 cells μm-2）, aggregation, and activation. The presence of nitrogen in the CNx coatings in- duced their enhanced hemocompatibility compared with DLC.
