Some novel peptide dendrimers bearing four amino acids, GD and RGD peptides on their surface were synthesized from tetrakis[（carboxyethoxy）methyl]-methane using DCC method.
THE Chinese knot is a decorative handicraft that is intricately woven with one single colored rope.Knot tying in China harks back to ancient times.Before Chinese writing appeared,people tied knots to make records of t...THE Chinese knot is a decorative handicraft that is intricately woven with one single colored rope.Knot tying in China harks back to ancient times.Before Chinese writing appeared,people tied knots to make records of their lives.The size and shape indicated the significance and nature of an event.展开更多
Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized...Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized the landscape of TPD but have the potential to unlock functionalities beyond degradation.Non-small-molecule-based approaches play an irreplaceable role in this field.A wide variety of agents spanning a broad chemical spectrum,including peptides,nucleic acids,antibodies,and even vaccines,which not only prove instrumental in overcoming the constraints of conventional small molecule entities but also provided rapidly renewing paradigms.Herein we summarize the burgeoning non-small molecule technological platforms inspired by PROTACs,including three major trajectories,to provide insights for the design strategies based on novel paradigms.展开更多
PRINTING is one of the four greatest inventions of ancient China.For millennia its mastery made China the sole country in the world able to produce copies of texts in great numbers and so build the largest repository ...PRINTING is one of the four greatest inventions of ancient China.For millennia its mastery made China the sole country in the world able to produce copies of texts in great numbers and so build the largest repository of books.Freed from time-consuming hand copying,the spread of culture and knowledge accelerated,ushering world civilization onto a new stage.展开更多
THE earliest Chinese characters,according to archaeological fi ndings,date back to the Yangshao Culture of the Neolithic Age,about 5,000 to 7,000 years ago.A writing system came into being in the Shang Dynasty(ca.17th...THE earliest Chinese characters,according to archaeological fi ndings,date back to the Yangshao Culture of the Neolithic Age,about 5,000 to 7,000 years ago.A writing system came into being in the Shang Dynasty(ca.17th-11th centuries BC).An immense cache of animal bones展开更多
SILK,that gorgeous fabric woven from mulberry silkworm(Bombyx mori)cocoons,is synonymous with China.The silk thread,ribbons and fabric that archaeological excavations of 1958 unearthed in Huzhou,Zhejiang Province,orig...SILK,that gorgeous fabric woven from mulberry silkworm(Bombyx mori)cocoons,is synonymous with China.The silk thread,ribbons and fabric that archaeological excavations of 1958 unearthed in Huzhou,Zhejiang Province,originated in the Liangzhu Culture of 4,700展开更多
SHADOW puppetry,also known as"shadow play,"is a traditional form of storytelling through the medium of flat articulated,elaborately engraved figures.Manipulating them with silken strings and bamboo rods betw...SHADOW puppetry,also known as"shadow play,"is a traditional form of storytelling through the medium of flat articulated,elaborately engraved figures.Manipulating them with silken strings and bamboo rods between a source of light and a translucent screen,puppeteers make the characters dance and sing to the accompaniment of percussion展开更多
基金the financial support of the National Natural Science Foundation of China （Project No. 20472055）.
文摘Some novel peptide dendrimers bearing four amino acids, GD and RGD peptides on their surface were synthesized from tetrakis[（carboxyethoxy）methyl]-methane using DCC method.
文摘THE Chinese knot is a decorative handicraft that is intricately woven with one single colored rope.Knot tying in China harks back to ancient times.Before Chinese writing appeared,people tied knots to make records of their lives.The size and shape indicated the significance and nature of an event.
基金supported by grants from the National Natural Science Foundation of China(22177084,82273559,82103757 and 82073473)the China Postdoctoral Science Foundation(2022M722283)+2 种基金PostDoctor Research Project,West China Hospital,Sichuan University(2023HXBH076,China)Sichuan Natural Science Foundation Project(2023NSFSC1554,China)the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21036,China).
文摘Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized the landscape of TPD but have the potential to unlock functionalities beyond degradation.Non-small-molecule-based approaches play an irreplaceable role in this field.A wide variety of agents spanning a broad chemical spectrum,including peptides,nucleic acids,antibodies,and even vaccines,which not only prove instrumental in overcoming the constraints of conventional small molecule entities but also provided rapidly renewing paradigms.Herein we summarize the burgeoning non-small molecule technological platforms inspired by PROTACs,including three major trajectories,to provide insights for the design strategies based on novel paradigms.
文摘PRINTING is one of the four greatest inventions of ancient China.For millennia its mastery made China the sole country in the world able to produce copies of texts in great numbers and so build the largest repository of books.Freed from time-consuming hand copying,the spread of culture and knowledge accelerated,ushering world civilization onto a new stage.
文摘THE earliest Chinese characters,according to archaeological fi ndings,date back to the Yangshao Culture of the Neolithic Age,about 5,000 to 7,000 years ago.A writing system came into being in the Shang Dynasty(ca.17th-11th centuries BC).An immense cache of animal bones
文摘SILK,that gorgeous fabric woven from mulberry silkworm(Bombyx mori)cocoons,is synonymous with China.The silk thread,ribbons and fabric that archaeological excavations of 1958 unearthed in Huzhou,Zhejiang Province,originated in the Liangzhu Culture of 4,700
文摘SHADOW puppetry,also known as"shadow play,"is a traditional form of storytelling through the medium of flat articulated,elaborately engraved figures.Manipulating them with silken strings and bamboo rods between a source of light and a translucent screen,puppeteers make the characters dance and sing to the accompaniment of percussion
