Dear Editor Extracellular environment plays a role in regulating stem cell fates and three dimensional （3D） scaffolds can be utilized to mimic the internal environment in vitro. Currently, many types of cells have b...Dear Editor Extracellular environment plays a role in regulating stem cell fates and three dimensional （3D） scaffolds can be utilized to mimic the internal environment in vitro. Currently, many types of cells have been cultured in 3D conditions but only few studies have focused on reprogramming in a 3D environment. 3D culture systems provide circumstances that can better simulate native conditions which are comprised of distinctive cell morphology, oxygen levels, extracellular matrix secretion and concentration gradients of signaling factors （Keung et al., 2010; Gu et al., 2016）.展开更多
文摘Dear Editor Extracellular environment plays a role in regulating stem cell fates and three dimensional （3D） scaffolds can be utilized to mimic the internal environment in vitro. Currently, many types of cells have been cultured in 3D conditions but only few studies have focused on reprogramming in a 3D environment. 3D culture systems provide circumstances that can better simulate native conditions which are comprised of distinctive cell morphology, oxygen levels, extracellular matrix secretion and concentration gradients of signaling factors （Keung et al., 2010; Gu et al., 2016）.
