Representing 2%-3% of adult cancers, renal cell carcinoma(RCC) accounts for 90% of renal malignancies and is the most lethal neoplasm of the urologic system. Over the last 65 years, the incidence of RCC has increased ...Representing 2%-3% of adult cancers, renal cell carcinoma(RCC) accounts for 90% of renal malignancies and is the most lethal neoplasm of the urologic system. Over the last 65 years, the incidence of RCC has increased at a rate of 2% per year. The increased incidence is at least partly due to improved tumor detection secondary to greater availability of high-resolution cross-sectional imaging modalities over the last few decades. Most RCCs are asymptomatic at discovery and are detected as unexpected findings on imaging performed for unrelated clinical indications. The 2004 World Health Organization Classification of adult renal tumors stratifies RCC into several distinct histologic subtypes of which clear cell, papillary and chromophobe tumors account for 70%, 10%-15%, and 5%, respectively. Knowledge of the RCC subtype is important because the various subtypes are associated with different biologic behavior, prognosis and treatment options. Furthermore, the common RCC subtypes can often be discriminated non-invasively based on gross morphologic imaging appearances, signal intensity on T2-weighted magnetic resonance images, and the degree of tumor enhancement on dynamic contrast-enhanced computed tomography or magnetic resonance imaging examinations. In this article, we review the incidence and survival data, risk factors, clinical and biochemical findings, imaging findings, staging, differential diagnosis, management options and posttreatment follow-up of RCC, with attention focused on the common subtypes.展开更多
To harness the rich solar energy resources in Xinjiang Region of Northwest China,this study tries to address the issue of lack of downward surface shortwave radiation(DSSR)observations and the need to improve the accu...To harness the rich solar energy resources in Xinjiang Region of Northwest China,this study tries to address the issue of lack of downward surface shortwave radiation(DSSR)observations and the need to improve the accuracy of satellite retrieval and numerical simulation of DSSR under varied sky and meteorological conditions.(1)A two-layer aerosol model specific to Xinjiang was developed to capture the vertical distributions of aerosols based on multiple data sources including lidar,GPS sounding,ground meteorological observations,and profiles from the ECMWF reanalysis version 5(ERA5)data.The results show that the ERA5/PBLH(planetary boundary layer height)and ERA5/ALH(aerosol layer height)could be used to establish the two-layer aerosol model and characterize the vertical distribution of aerosols in Xinjiang Region.(2)Using the Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART)model,a localized inverse model of clear-sky DSSR was established.After parameter adjustment and using the optimal combination of input parameters for DSSR simulation together with the two-layer aerosol model,the model-simulated DSSR(DSSRSBD)under clear-sky conditions improved significantly compared to the initial results,with all fitting indices greatly improved.(3)In addition,the study demonstrated that the impact of the two-layer aerosol model on DSSR was more pronounced under dust conditions than clear-sky conditions.(4)Using the localized clear-sky DSSR inversion model and its required parameters,simulations were also conducted to capture the spatiotemporal distribution of DSSR under clear-sky conditions in Xinjiang from 2017 to 2019.The annual average DSSR_(SBD)under clear-sky conditions in Xinjiang during 2017–2019 was 606.78 W m^(-2),while DSSR from CERES(DSSR_(CER))under the same conditions was generally higher(703.95 W m^(-2)).(5)It is found that satellite remote sensing products experienced data loss in high-altitude snow areas,where numerical simulation technology could serve as a valuable complement.展开更多
Although small EVs(sEVs)have been used widely as biomarkers in disease diagnosis,their heterogeneity at single EV level has rarely been revealed.This is because high-resolution characterization of sEV presents a major...Although small EVs(sEVs)have been used widely as biomarkers in disease diagnosis,their heterogeneity at single EV level has rarely been revealed.This is because high-resolution characterization of sEV presents a major challenge,as their sizes are below the optical diffraction limit.Here,we report that upconversion nanoparticles(UCNPs)can be used for super-resolution profiling the molecular heterogeneity of sEVs.We show that Er3+-doped UCNPs has better brightness and Tm3+-doped UCNPs resulting in better resolution beyond diffraction limit.Through an orthogonal experimental design,the specific targeting of UCNPs to the tumour epitope on single EV has been cross validated,resulting in the Pearson’s R-value of 0.83 for large EVs and~65%co-localization double-positive spots for sEVs.Furthermore,super-resolution nanoscopy can distinguish adjacent UCNPs on single sEV with a resolution of as high as 41.9 nm.When decreasing the size of UCNPs from 40 to 27 nm and 18 nm,we observed that the maximum UCNPs number on single sEV increased from 3 to 9 and 21,respectively.This work suggests the great potentials of UCNPs approach“digitally”quantify the surface antigens on single EVs,therefore providing a solution to monitor the EV heterogeneity changes along with the tumour progression progress.展开更多
The microstructure of 2624-T39 aluminum alloy was analyzed by means of metallographic(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM). The effects of different microstructure character...The microstructure of 2624-T39 aluminum alloy was analyzed by means of metallographic(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM). The effects of different microstructure characteristics on the tensile properties and fatigue crack growth rate of 2624-T39 aluminum alloy were studied.Results showed that the grain size of the alloy was a typical fiber structure along the rolling direction, and the main second phase was the A_(l2)CuMg phase. The grain size of the alloy had an obvious influence on the fatigue crack growth rate, and the alloy showed a lower fatigue crack growth rate due to the larger grain size. The crack initiation zone on the fracture surface of alloys with lower fatigue crack growth rate was relatively rough, the crack propagation zone had obvious fatigue striations, and the transient fracture zone had a large number of smaller dimples.展开更多
In this paper,we introduce a new notion of integrability for billiard tables,namely,integrability away from the boundary.One key feature of our notion is that the integrable region could be disjoint from the boundary ...In this paper,we introduce a new notion of integrability for billiard tables,namely,integrability away from the boundary.One key feature of our notion is that the integrable region could be disjoint from the boundary with a positive distance.We prove that if a strictly convex billiard table,whose boundary is a small perturbation of an ellipse with small eccentricity,is integrable in this sense,then its boundary must be itself an ellipse.展开更多
Phyllanthus hainanensis is a shrub that has been used in traditional herbal medicine.It has great pharmaceutical potential for treating diseases such as cancer and diabetes.As a prerequisite for propagation of this sp...Phyllanthus hainanensis is a shrub that has been used in traditional herbal medicine.It has great pharmaceutical potential for treating diseases such as cancer and diabetes.As a prerequisite for propagation of this species on a large scale,hairy roots in P.hainanensis were induced using Rhizobium rhizogenes and various factors affecting hairy root induction and growth evaluated.Seven factors were tested:(1)type of explant,(2)type of culture medium,(3)duration of pre-culture,(4)R.rhizogenes inoculum cell density,(5)duration of infection,(6)acetosyringone concentration in the culture medium,and(7)duration of incubation.The optimal protocol for hairy root induction and growth was:young shoots,pre-cultured in Y1 for 2 d,inoculated with R.rhizogenes broth with an OD600 of 0.6 for 20 min,and incubated for 3 d.Putative transgenic hairy roots were initially identified by morphology and then confirmed by polymerase chain reaction.Successful and optimal production of hairy roots is a critical prerequisite for industrial scale clonal propagation of P.hainanensis.Being able to cultivate the plant on a large scale will provide rapid and ready supply of the plant materials that can be used in herbal medicine and in scientific and industrial exploitation.展开更多
文摘Representing 2%-3% of adult cancers, renal cell carcinoma(RCC) accounts for 90% of renal malignancies and is the most lethal neoplasm of the urologic system. Over the last 65 years, the incidence of RCC has increased at a rate of 2% per year. The increased incidence is at least partly due to improved tumor detection secondary to greater availability of high-resolution cross-sectional imaging modalities over the last few decades. Most RCCs are asymptomatic at discovery and are detected as unexpected findings on imaging performed for unrelated clinical indications. The 2004 World Health Organization Classification of adult renal tumors stratifies RCC into several distinct histologic subtypes of which clear cell, papillary and chromophobe tumors account for 70%, 10%-15%, and 5%, respectively. Knowledge of the RCC subtype is important because the various subtypes are associated with different biologic behavior, prognosis and treatment options. Furthermore, the common RCC subtypes can often be discriminated non-invasively based on gross morphologic imaging appearances, signal intensity on T2-weighted magnetic resonance images, and the degree of tumor enhancement on dynamic contrast-enhanced computed tomography or magnetic resonance imaging examinations. In this article, we review the incidence and survival data, risk factors, clinical and biochemical findings, imaging findings, staging, differential diagnosis, management options and posttreatment follow-up of RCC, with attention focused on the common subtypes.
基金Science and Technology Planning Program of Xinjiang(2022E01047)National Natural Science Foundation of China(42030612 and 41905131)+2 种基金Scientific Research Program Funded by Education Department of Shaanxi Provincial Government(23JK0625)Natural Science Basic Research Program of Shaanxi Province(2021JQ-768)Social Science Planning Fund Program of Xi’an City(23JX150)。
文摘To harness the rich solar energy resources in Xinjiang Region of Northwest China,this study tries to address the issue of lack of downward surface shortwave radiation(DSSR)observations and the need to improve the accuracy of satellite retrieval and numerical simulation of DSSR under varied sky and meteorological conditions.(1)A two-layer aerosol model specific to Xinjiang was developed to capture the vertical distributions of aerosols based on multiple data sources including lidar,GPS sounding,ground meteorological observations,and profiles from the ECMWF reanalysis version 5(ERA5)data.The results show that the ERA5/PBLH(planetary boundary layer height)and ERA5/ALH(aerosol layer height)could be used to establish the two-layer aerosol model and characterize the vertical distribution of aerosols in Xinjiang Region.(2)Using the Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART)model,a localized inverse model of clear-sky DSSR was established.After parameter adjustment and using the optimal combination of input parameters for DSSR simulation together with the two-layer aerosol model,the model-simulated DSSR(DSSRSBD)under clear-sky conditions improved significantly compared to the initial results,with all fitting indices greatly improved.(3)In addition,the study demonstrated that the impact of the two-layer aerosol model on DSSR was more pronounced under dust conditions than clear-sky conditions.(4)Using the localized clear-sky DSSR inversion model and its required parameters,simulations were also conducted to capture the spatiotemporal distribution of DSSR under clear-sky conditions in Xinjiang from 2017 to 2019.The annual average DSSR_(SBD)under clear-sky conditions in Xinjiang during 2017–2019 was 606.78 W m^(-2),while DSSR from CERES(DSSR_(CER))under the same conditions was generally higher(703.95 W m^(-2)).(5)It is found that satellite remote sensing products experienced data loss in high-altitude snow areas,where numerical simulation technology could serve as a valuable complement.
基金Science and Technology Innovation Commission of Shenzhen(KQTD20170810110913065,20200925174735005)Australia China Science and Research Fund Joint Research Centre for Point-of-Care Testing(ACSRF658277,SQ2017YFGH001190)ARC Laureate Fellowship Program(D.J.,FL210100180)。
文摘Although small EVs(sEVs)have been used widely as biomarkers in disease diagnosis,their heterogeneity at single EV level has rarely been revealed.This is because high-resolution characterization of sEV presents a major challenge,as their sizes are below the optical diffraction limit.Here,we report that upconversion nanoparticles(UCNPs)can be used for super-resolution profiling the molecular heterogeneity of sEVs.We show that Er3+-doped UCNPs has better brightness and Tm3+-doped UCNPs resulting in better resolution beyond diffraction limit.Through an orthogonal experimental design,the specific targeting of UCNPs to the tumour epitope on single EV has been cross validated,resulting in the Pearson’s R-value of 0.83 for large EVs and~65%co-localization double-positive spots for sEVs.Furthermore,super-resolution nanoscopy can distinguish adjacent UCNPs on single sEV with a resolution of as high as 41.9 nm.When decreasing the size of UCNPs from 40 to 27 nm and 18 nm,we observed that the maximum UCNPs number on single sEV increased from 3 to 9 and 21,respectively.This work suggests the great potentials of UCNPs approach“digitally”quantify the surface antigens on single EVs,therefore providing a solution to monitor the EV heterogeneity changes along with the tumour progression progress.
基金financially supported by the National Key R&D Program of China(No.2016YFB0300800)。
文摘The microstructure of 2624-T39 aluminum alloy was analyzed by means of metallographic(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM). The effects of different microstructure characteristics on the tensile properties and fatigue crack growth rate of 2624-T39 aluminum alloy were studied.Results showed that the grain size of the alloy was a typical fiber structure along the rolling direction, and the main second phase was the A_(l2)CuMg phase. The grain size of the alloy had an obvious influence on the fatigue crack growth rate, and the alloy showed a lower fatigue crack growth rate due to the larger grain size. The crack initiation zone on the fracture surface of alloys with lower fatigue crack growth rate was relatively rough, the crack propagation zone had obvious fatigue striations, and the transient fracture zone had a large number of smaller dimples.
基金Supported by NSFC(Significant Pro ject No.11790273)in China。
文摘In this paper,we introduce a new notion of integrability for billiard tables,namely,integrability away from the boundary.One key feature of our notion is that the integrable region could be disjoint from the boundary with a positive distance.We prove that if a strictly convex billiard table,whose boundary is a small perturbation of an ellipse with small eccentricity,is integrable in this sense,then its boundary must be itself an ellipse.
基金This work was supported by China Research Funds for Universities(2662016QD021).
文摘Phyllanthus hainanensis is a shrub that has been used in traditional herbal medicine.It has great pharmaceutical potential for treating diseases such as cancer and diabetes.As a prerequisite for propagation of this species on a large scale,hairy roots in P.hainanensis were induced using Rhizobium rhizogenes and various factors affecting hairy root induction and growth evaluated.Seven factors were tested:(1)type of explant,(2)type of culture medium,(3)duration of pre-culture,(4)R.rhizogenes inoculum cell density,(5)duration of infection,(6)acetosyringone concentration in the culture medium,and(7)duration of incubation.The optimal protocol for hairy root induction and growth was:young shoots,pre-cultured in Y1 for 2 d,inoculated with R.rhizogenes broth with an OD600 of 0.6 for 20 min,and incubated for 3 d.Putative transgenic hairy roots were initially identified by morphology and then confirmed by polymerase chain reaction.Successful and optimal production of hairy roots is a critical prerequisite for industrial scale clonal propagation of P.hainanensis.Being able to cultivate the plant on a large scale will provide rapid and ready supply of the plant materials that can be used in herbal medicine and in scientific and industrial exploitation.