期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Theranostic gold cluster nanoassembly for simultaneous enhanced cancer imaging and photodynamic therapy 被引量:3
1
作者 Hao-Dong Cui De-Hong Hu +6 位作者 Jing-Nan Zhang guan-hui gao Cui-Fang Zheng Ping Gong Xing-Hua Xi Zong-Hai Sheng Lin-Tao Cai 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第7期1391-1398,共8页
As one of near-infrared(NIR) fluorescent(FL) nanoprobes, gold nanoclusters(Au NCs) are delicated to passive-targeting tumors for NIR FL imaging, but which easily cleared by the kidneys for the small size(〈1.5... As one of near-infrared(NIR) fluorescent(FL) nanoprobes, gold nanoclusters(Au NCs) are delicated to passive-targeting tumors for NIR FL imaging, but which easily cleared by the kidneys for the small size(〈1.5 nm). Herein, the well-defined gold clusters nanoassembly(Au CNA) was synthesized by the selfassembly of Au NCs based on protein cross-linking approach. The as-prepared Au CNA demonstrated highly effective cellular uptake and precise tumor targeting compared to that of Au NCs. Moreover, with the irradiation of 660 nm laser, Au CNA generated largely reactive oxygen species(ROS) for photodynamic therapy(PDT). In vitro and [39TD$IF]in vivo PDT revealed that Au CNA exhibited largely cell death and significantly tumor removal at a low power density of 0.2 W/cm^2. It could be speculated that the laser-excited Au CNA produced photon energy, which further obtained electron from oxygen to generate radical species.Therefore, Au CNA as a photosensitizer could realize NIR FL imaging and NIR laser induced PDT. 展开更多
关键词 Gold nanoclusters Self-assembly Near-infrared fluorescent nanoprobe In vivo imaging Photodynamic therapy
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部