Network meta-analysis of the effectiveness of TCM external treatment in the treatment of mycoplasmal pneumonia

Objective: To compare the efficacy and safety of different TCM external treatment combined with azithromycin in the treatment of Mycoplasma pneumoniae pneumonia. Methods: The keywords and free words were combined to search the literatures of clinical randomized or quasi-randomized controlled trials on the effects of TCM external treatment combined with azithromycin in the treatment of children with MPP in CNKI, VIP, CBM, Wan Fang Date, PubMed, Sciencedirect and Google Academic Database. The search time limit is from August 2019. After two independent reviewers selected the literature, extracted data and literature quality evaluation according to the inclusion and exclusion criteria, the ADDI software, RevMan5.3 and stata14.0 software were used for mesh meta-analysis. Results: A total of 18 randomized controlled literatures were included, involving 1536 children with MPP, 6 Chinese medicine external treatment methods (ultra-short wave, acupoint application, cupping, enema, Chinese medicine patch, massage). The results of mesh meta-analysis showed that treatment In terms of MPP efficiency, ultrashort wave, acupoint application, cupping, enema, Chinese medicine patch, massage combined with azithromycin treatment is more effective than azithromycin alone, and the probability distribution shows that the Chinese medicine patch combined with azithromycin treatment is the best solution (P= 0.34). In the reduction of adverse reactions, because the ultrashort wave and traditional Chinese medicine patch literature did not mention the non-performing rate, this study only analyzed the other four external treatment methods, acupoint application, cupping, enema, massage combined with azithromycin is better than single With azithromycin, the probability distribution showed that the probability of massage combined with azithromycin was the best (P=0.67). Conclusion: In terms of efficiency and reduction of adverse reactions, each Chinese medicine external treatment combined with azithromycin has an advantage over single azithromycin. Probability distribution shows that in the treatment of MPP efficiency, Chinese medicine patch + Achi > ultrashort wave + AZM > enema + AZM > cupping + AZM > massage + Aqi, Chinese medicine patch + azithromycin program is the optimal program;In terms of reducing adverse reactions, massage + AZM > enema + AZM > acupressure application + AZM > cupping +AZM.

Meta-analysis of the effects of inflammatory factors on children with pneumonia mycoplasma pneumonia

Objective:To evaluate the effect of Mycoplasma pneumoniae pneumonia (MPP) on inflammatory factors.Methods:Using the combination of subject terms and free words to search the literature on the effect of children with MPP on inflammatory factors.Retrieved from CNKI, VIP,CBM, Wanfang Database, Pubmed Database, Sciencedirect Database and Google scholor. etc.Time period of retrieval was from database established to May. 2019. 2 researchers conducted literature screening independently according to the inclusion and exclusion criteria. and then processed quality evaluation.RevMan5.3 and stata 14.0 were adopted to conduct Meta analysis on all effective indicators. Results:A total of 23 studies were involved, including 2254 children with MPP and 1182 healthy children. Results of Meta analysis showed IL-6 level(SMD=17.74, 95% CI =15.38~20.09,P<0.0001)、IL-8 level (SMD=19.40,95% CI=18.12~20.69,P<0.0001)、IL-10 level (SMD=9.51,95% CI =8.25~10.97,P<0.0001)、TNF-a level (SMD=31.06,95% CI =24.57~37.54,P<0.0001) were significantly better than the control group, the difference were statistically significant. Subgroup analysis:SMPP compared with MPP, IL-6 level (SMD=12.02, 95% CI =7.08~16.96,P<0.0001)was significantly better than the control group, the difference were statistically significant;Compared with the recovery period, the acute phase of children with MPP, IL-6 level (SMD=20.53, 95% CI =17.51~23.56,P<0.0001)、IL-8 level (SMD=17.27,95% CI=10.14~24.40,P<0.0001)、IL-10 level (SMD=6.04,95% CI =1.72~10.36,P<0.0001)、TNF-a level (SMD=23.64,95% CI =17.60~29.69,P<0.0001) were significantly better than the control group, the difference was statistically significant. Conclusions:MPP caused elevated levels of IL-6, IL-8, IL-10, and TNF-a inflammatory factors in the serum of children, and the levels of inflammatory factors were directly proportional to the severity of the disease.