Glaucoma is a leading cause of irreversible blindness in the world.Intraocular pressure(IOP)plays a key role in glaucoma development and progression.Schlemm’s canal(SC),an important structure of the anterior chamber ...Glaucoma is a leading cause of irreversible blindness in the world.Intraocular pressure(IOP)plays a key role in glaucoma development and progression.Schlemm’s canal(SC),an important structure of the anterior chamber angle,regulates the flow of aqueous humor and maintains IOP.Because of its special function of aqueous outflow,the SC has been intensive investigated recently.Several characteristics of SC in anatomy,physiology and pathophysiology have been revealed.Compare to normal,glaucomatous SC cells are more sensitive to substrate stiffness,have higher stiffness and and lower porosity leading to higher outflow resistance.And SC collapse caused by acute IOP increase is partially or totally reversal.With advanced inspection techniques,high-quality images of the SC can be obtained in vivo,which facilitates SC quantitative measurements clinically and allows us to investigate a new therapy paradigm for glaucoma.In this review,we summarize the basic and clinical research that focused on mechanisms of aqueous outflow resistance and SC changes in physiological,pathological,and posttreatment states.展开更多
To the Editor： Cblam.~zti^t organisms belong to intracellular bacterial pathogens which are responsible for a range of human diseases, including trachoma, sexually transmitted disease, pneumonia, and other diseases. ...To the Editor： Cblam.~zti^t organisms belong to intracellular bacterial pathogens which are responsible for a range of human diseases, including trachoma, sexually transmitted disease, pneumonia, and other diseases. Some Chlamydia-infected diseases were old and had long time impacted on the people＇s health in China and worldwide, but people cannot put enough emphasis on it in local areas.展开更多
基金Supported by the National Key R&D Program of China(No.2017YFB1302703)。
文摘Glaucoma is a leading cause of irreversible blindness in the world.Intraocular pressure(IOP)plays a key role in glaucoma development and progression.Schlemm’s canal(SC),an important structure of the anterior chamber angle,regulates the flow of aqueous humor and maintains IOP.Because of its special function of aqueous outflow,the SC has been intensive investigated recently.Several characteristics of SC in anatomy,physiology and pathophysiology have been revealed.Compare to normal,glaucomatous SC cells are more sensitive to substrate stiffness,have higher stiffness and and lower porosity leading to higher outflow resistance.And SC collapse caused by acute IOP increase is partially or totally reversal.With advanced inspection techniques,high-quality images of the SC can be obtained in vivo,which facilitates SC quantitative measurements clinically and allows us to investigate a new therapy paradigm for glaucoma.In this review,we summarize the basic and clinical research that focused on mechanisms of aqueous outflow resistance and SC changes in physiological,pathological,and posttreatment states.
文摘To the Editor： Cblam.~zti^t organisms belong to intracellular bacterial pathogens which are responsible for a range of human diseases, including trachoma, sexually transmitted disease, pneumonia, and other diseases. Some Chlamydia-infected diseases were old and had long time impacted on the people＇s health in China and worldwide, but people cannot put enough emphasis on it in local areas.
