(3R, 9S, 10S)-Heptadec-1-ene-4,6-diyne-3, 9, 10-triol 2, a diastereoisomer of panaxytriol 1 was synthesized using L-(+)-diethyl tartrate 5 as a chiral template, through the Cadiot-Chodkiczwicz coupling of the terminal...(3R, 9S, 10S)-Heptadec-1-ene-4,6-diyne-3, 9, 10-triol 2, a diastereoisomer of panaxytriol 1 was synthesized using L-(+)-diethyl tartrate 5 as a chiral template, through the Cadiot-Chodkiczwicz coupling of the terminal acetylene 3 with bromoacetylene 4.展开更多
The first stereoselective total synthesis of 3 (R)-panaxynol 1 has been achieved byutilizing the Cadiot-Chodkiczwicz reaction, through coupling of 3 (R)- (t-butyldiphenylsilyloxy)1-penten-4-yne with 1 -bromo-alkyne co...The first stereoselective total synthesis of 3 (R)-panaxynol 1 has been achieved byutilizing the Cadiot-Chodkiczwicz reaction, through coupling of 3 (R)- (t-butyldiphenylsilyloxy)1-penten-4-yne with 1 -bromo-alkyne compound.展开更多
3(R)-(t-Butyldiphenylsilyloxy)-1-penten-4-yne was prepared using D-xylose as the chiral template via an improved procedure for aldehyde-to-alkyne homologation in high yield.
文摘(3R, 9S, 10S)-Heptadec-1-ene-4,6-diyne-3, 9, 10-triol 2, a diastereoisomer of panaxytriol 1 was synthesized using L-(+)-diethyl tartrate 5 as a chiral template, through the Cadiot-Chodkiczwicz coupling of the terminal acetylene 3 with bromoacetylene 4.
文摘The first stereoselective total synthesis of 3 (R)-panaxynol 1 has been achieved byutilizing the Cadiot-Chodkiczwicz reaction, through coupling of 3 (R)- (t-butyldiphenylsilyloxy)1-penten-4-yne with 1 -bromo-alkyne compound.
文摘3(R)-(t-Butyldiphenylsilyloxy)-1-penten-4-yne was prepared using D-xylose as the chiral template via an improved procedure for aldehyde-to-alkyne homologation in high yield.
