Hepatocellular carcinoma(HCC)is one of the most prevalent malignant cancers worldwide.Epithelialmesenchymal transition(EMT),which endows epithelial cells with mesenchymal properties,plays an important role in the earl...Hepatocellular carcinoma(HCC)is one of the most prevalent malignant cancers worldwide.Epithelialmesenchymal transition(EMT),which endows epithelial cells with mesenchymal properties,plays an important role in the early stages of metastasis.Conventional cancer therapies have promising effects,but issues remain,such as high rates of metastasis and drug resistance.Thus,exploring and evaluating new therapies is an urgent need.Traditional Chinese medicines(TCMs)have been acknowledged for their multi-target and coordinated intervention effects against HCC.Accumulating evidence indicates that TCM can inhibit the malignancy of cells and the progression of EMT in HCC.However,studies on the effects of TCM on EMT in HCC are scarce.In this review,we summarized recent developments in anti-EMT TCMs and formulae,focusing on their underlying pharmacological mechanisms,to provide a foundation for further research on the exact mechanisms through which TCM affects EMT in HCC.展开更多
基金supported by Natural Science Foundation of Shanghai Minhang District(No.2019MHZ062)Shanghai Key Specialty Construction Project of Clinical Pharmacy(Minhang District,No.2018YXZDZK)+1 种基金National Natural Science Foundation of China(No.81700065)the Talent Development Special Funds(leading talent)project of Shanghai Minhang District。
文摘Hepatocellular carcinoma(HCC)is one of the most prevalent malignant cancers worldwide.Epithelialmesenchymal transition(EMT),which endows epithelial cells with mesenchymal properties,plays an important role in the early stages of metastasis.Conventional cancer therapies have promising effects,but issues remain,such as high rates of metastasis and drug resistance.Thus,exploring and evaluating new therapies is an urgent need.Traditional Chinese medicines(TCMs)have been acknowledged for their multi-target and coordinated intervention effects against HCC.Accumulating evidence indicates that TCM can inhibit the malignancy of cells and the progression of EMT in HCC.However,studies on the effects of TCM on EMT in HCC are scarce.In this review,we summarized recent developments in anti-EMT TCMs and formulae,focusing on their underlying pharmacological mechanisms,to provide a foundation for further research on the exact mechanisms through which TCM affects EMT in HCC.
