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Polyhydric Corrole and Its Gallium Complex: Synthesis, DNA-binding Properties and Photodynamic Activities
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作者 Zhenhua Liang Haiyang Liu +3 位作者 guangbin jiang Jinyan Wen Yunjun Liu Xinyan Xiao 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2016年第10期997-1005,共9页
A new hydrophilic polyhydric corrole (1) and its Ga(III) complex (1-Ga) were synthesized and characterized. Corroles 1 and 1-Ga bind to calf thymus DNA externally and exhibit remarkable photonuclease-like activi... A new hydrophilic polyhydric corrole (1) and its Ga(III) complex (1-Ga) were synthesized and characterized. Corroles 1 and 1-Ga bind to calf thymus DNA externally and exhibit remarkable photonuclease-like activity. Singlet oxygen (102) was identified as the reactive oxygen species involved. These corroles also exhibit significant photocytotoxicity against HeLa, A549, BEL-7402 and HepG2 tumor cell lines. They mainly accumulated in the nuclei of tumor cells. ROS-mediated mitochondrial damage and intracellular DNA disintegration contributed to the observed photodynamic activity. 展开更多
关键词 CORROLES GALLIUM DNA binding PHOTOSENSITIZERS ANTICANCER
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