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lncRNA调控绝经后骨质疏松及其机制研究 被引量:1
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作者 毕凤江 侯庆露 +2 位作者 赵广军 郑玲莉 史景玉 《国际感染病学(电子版)》 CAS 2018年第4期192-193,共2页
目的探究lncRNA调控绝经后骨质疏松的途径及其机制。方法采用小鼠建立模型进行对比研究。适应环境一周之后,摘除模型组小鼠双侧卵巢,对照组小鼠保留卵巢。给予相同的粮食喝水,保证其正常生长发育。饲养8周后提取RNA并进行后续检测实验... 目的探究lncRNA调控绝经后骨质疏松的途径及其机制。方法采用小鼠建立模型进行对比研究。适应环境一周之后,摘除模型组小鼠双侧卵巢,对照组小鼠保留卵巢。给予相同的粮食喝水,保证其正常生长发育。饲养8周后提取RNA并进行后续检测实验。结果模型组小鼠骨组织和骨髓间充质干细胞中lncRNA HOTAIR的表达显著升高,成骨相关基因显著降低,成脂基因显著升高,过表达lncRNA HOTAIR能够降低成骨相关基因的表达,上调成脂相关基因的表达;敲减lncRNA HOTAIR能够升高成骨相关基因的表达,降低成脂相关基因的表达。结论lncRNA可以作为生物标记物应用到绝经后骨质疏松患者的诊断和治疗当中,值得在临床上推广应用。 展开更多
关键词 lncRNA 绝经后骨质疏松 机制
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A Comparison between TGT and Cz Grown Nd:YAG
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作者 Benxue JIANG Jun XU +2 位作者 Hongjun LI Jingya WANG guangjun zhao 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2006年第5期581-583,共3页
Large sized neodymium-doped Y3Al5O12 (Nd:YAG) laser crystals have been grown by temperature gradient technique (TGT) method and compared with Czochralski (Cz) method. The comparison of these two crystal growth ... Large sized neodymium-doped Y3Al5O12 (Nd:YAG) laser crystals have been grown by temperature gradient technique (TGT) method and compared with Czochralski (Cz) method. The comparison of these two crystal growth methods has been listed. The results showed that the TGT method has many advantages over the Cz method. The concentration distribution of Nd ions in the crystals was determined and the absorption spectra of these crystals have been investigated and compared. The TGT grown highly doped Nd:YAG crystal has a larger absorption FWHM than that of Cz grown Nd:YAG crysral. Highly doped Nd:YAG (~2.8 at. pct) crystals could be obtained by TGT. 展开更多
关键词 Nd:YAG Spectral properties Czochralski method TGT method FACET
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