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生物信息学分析CETP基因在肝癌中表达及其对预后和免疫的影响
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作者 陈显育 曾谣 +4 位作者 莫钊鸿 翟航 张广权 钟造茂 陈署贤 《中华肝脏外科手术学电子杂志》 CAS 2024年第2期214-219,共6页
目的:探讨胆固醇酯转移蛋白(CETP)在原发性肝癌(肝癌)中表达及其对预后和免疫的影响。方法:下载GEO数据集GSE101685、GSE45267、GSE62232,以及ImmPort数据库人类免疫相关基因(IRGs),联合筛选差异表达的下调基因并选择未研究过的基因CET... 目的:探讨胆固醇酯转移蛋白(CETP)在原发性肝癌(肝癌)中表达及其对预后和免疫的影响。方法:下载GEO数据集GSE101685、GSE45267、GSE62232,以及ImmPort数据库人类免疫相关基因(IRGs),联合筛选差异表达的下调基因并选择未研究过的基因CETP。使用UALCAN和Kaplan-Meier Plotter数据库分别分析CETP在肝癌中的表达和其与肝癌患者预后的关系。LinkedOmics数据库进行基因本体(GO)分析和KEGG通路基因富集分析。Timer数据库及TISIDB数据库分析CETP与肝癌免疫细胞浸润、免疫调节剂的相关性。结果:3个肝癌数据集及ImmPort数据库筛选出共有的16个差异基因,从中选择下调的关键基因CETP。UALCAN数据库显示,与正常组织相比,CETP基因在肝癌组织中表达水平降低(P<0.05);CETP表达与美国癌症联合委员会(AJCC)分期、淋巴结转移密切相关(P<0.05)。Kaplan-Meier Plotter数据库分析显示,CETP基因低表达患者中位生存时间37.8个月,明显短于高表达患者的61.7个月(HR=0.66,P<0.05)。GO分析显示,CETP相关基因主要参与免疫反应、白细胞粘附、细胞死亡、细胞趋化等活动;KEGG通路分析显示,CETP基因在NK细胞介导的细胞毒性、细胞因子-细胞因子受体相互作用、氧化磷酸化、Th1和Th2细胞分化等通路中富集。TIMER数据库及TISIDB数据库表明CETP与肝癌中树突状细胞、CD8+T细胞免疫细胞浸润水平及免疫调节剂相关。结论:在线数据库分析表明,CETP基因在肝癌中表达下调,CETP低表达与患者临床特征和不良预后相关,CETP表达的改变可影响免疫应答,从而可能影响患者预后。 展开更多
关键词 肝细胞 胆固醇酯转移蛋白(CETP) 预后 免疫 生物信息学
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Pollution morphology characteristics on a superhydrophobic surface and its pollution flashover voltage in DC electric field 被引量:1
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作者 Yijie Liu Yujun Guo +6 位作者 Bo Wang Xueqin zhang Guizao Huang guangquan zhang Yicen Liu Qin Deng Guangning Wu 《High Voltage》 SCIE EI 2022年第3期564-574,共11页
To solve the pollution problem of insulators on ultra-high voltage DC transmission lines,superhydrophobic coatings were presented and their pollution deposit morphology and pollution flashover voltage in electric fiel... To solve the pollution problem of insulators on ultra-high voltage DC transmission lines,superhydrophobic coatings were presented and their pollution deposit morphology and pollution flashover voltage in electric field were studied by an artificial pollution deposit system.The experimental results show that the pollution on the surface of super-hydrophobic coating is distributed in clusters,which inhibits the chain distribution on the surface of silicone rubber and improves the pollution flashover voltage.Secondly,the competition mechanism of the pollution flashover on the superhydrophobic coating surface was found.This competition mechanism can lead to the failure of the insulation performance of the superhydrophobic coating in severely polluted environments.Finally,a pollution flashover model of superhydrophobic coating is proposed to explain the competition mechanism,which is affected by pollution and the discrete droplets.The conclusions of this study can provide an experimental and theoretical basis for the application of the superhydrophobic coating in the field of UHV DC external insulation. 展开更多
关键词 COATING FLASH SURFACE
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